Ghrelin and sleep-wake regulation

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 292, Issue 1, 2007, Pages

  Steiger, Axel ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GROWTH HORMONE RELEASING FACTOR; HEXARELIN; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE;

EDITORIAL; ELECTROENCEPHALOGRAM; FEEDING BEHAVIOR; FOOD INTAKE; HORMONE BLOOD LEVEL; HUMAN; HYPOTHALAMUS; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; SLEEP DEPRIVATION; SLEEP WAKING CYCLE;

ANIMALS; GROWTH HORMONE-RELEASING HORMONE; HUMANS; HUNGER; INJECTIONS, INTRAVENTRICULAR; MICE; PEPTIDE HORMONES; RATS; SLEEP; SLEEP, REM; WAKEFULNESS;

EID: 33846178218     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00618.2006     Document Type: Editorial

References (17)

1. Bodosi B, Gardi J, Hajdu I, Szentirmai E, Obál F Jr, Krueger JM. Rhythms of ghrelin, leptin, and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am J Physiol Regul Integr Comp Physiol 287: R1071-R1079, 2004.
2. Frieboes RM, Antonijevic IA, Held K, Murck H, Pollmächer T, Uhr M, Steiger A. Hexarelin decreases slow-wave sleep and stimulates the sleep-related secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. Psychoneuroendocrinology 29: 851-860, 2004.
3. Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology 61: 584-589, 1995.
4. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth hormone-releasing acylated peptide from stomach. Nature 402: 656-660, 1999.
5. Obál F Jr, Alt J, Taishi P, Gardi J, Krueger JM. Sleep in mice with non-functional growth hormone-releasing hormone receptors. Am J Physiol Regul Integr Comp Physiol 284: R131-R139, 2003.
6. Obál F Jr, Krueger JM. GHRH and sleep. Sleep Med Rev 8: 367-377, 2004.
7. Rosenhagen MC, Uhr M, Schüssler P, Steiger A. Elevated plasma ghrelin levels in night-eating syndrome. Am J Psychiatry 162: 813, 2005.
8. Schmid DA, Held K, Ising M, Uhr M, Weikel JC, Steiger A. Ghrelin stimulates appetite, imagination of food, GH, ACTH and cortisol, but does not affect leptin in normal controls. Neuropsychopharmacology 30: 1187-1192, 2005.
9. Schüssler P, Uhr M, Ising M, Weikel JC, Schmid DA, Held K, Mathias S, Steiger A. Nocturnal ghrelin, ACTH, GH and cortisol secretion after sleep deprivation in humans. Psychoneuroendocrinology 31: 915-923, 2006.
10. Steiger A. Eating and sleeping - their relationship to ghrelin and leptin. Am J Physiol Regul Integr Comp Physiol 287: R1031-R1032, 2004.
11. Steiger A. Neurochemical regulation of sleep. Journal of Psychiatric Research. In press.
12. Szentirmai E, Hajdu I, Obál F Jr, Krueger JM. Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res 1088: 131-140, 2006.
13. Szentirmai É, Kapás L, Krueger JM. Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol Regul Integr Comp Physiol 292: R575-R585, 2007.
14. Tolle V, Bassant MH, Zizzari P, Poindessous-Jazat F, Tomasetto C, Epelbaum J, and Bluet-Pajot MT. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 143: 1353-1361, 2002.
15. van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25: 426-457, 2004.
16. Weikel J, Held K, Schmid DA, Uhr M, Steiger A. Single case report: 100 μg ghrelin at 22:00 increases distinctly hunger, food intake and nocturnal plasma levels of GH, ACTH and cortisol in a young man - evidence for dose-dependent effects of ghrelin on appetite? (Abstract) Pharmacopsychiatry 38: 284, 2005.
17. Weikel JC, Wichniak A, Ising M, Brunner H, Friess E, Held K, Mathias S, Schmid DA, Uhr M, Steiger A. Ghrelin promotes slow-wave sleep in humans. Am J Physiol Endocrinol Metab 284: E407-E415, 2003.