Effect of subdividing the adsorbent bed in a five-zone simulated moving bed chromatography for ternary separation

Journal of Liquid Chromatography and Related Technologies

Volumn 31, Issue 9, 2008, Pages 1231-1257

  Mun, Sungyong ^a  

^a Hanyang University   (South Korea)

Author keywords

Bed subdivision; Five zone SMB; Separation performance; Wave dynamics

Indexed keywords

ADSORBENTS; CHROMATOGRAPHY; OPTIMIZATION; PHASE SEPARATION; WAVE EQUATIONS;

BED SUBDIVISION; SEPARATION PERFORMANCE; SIMULATED MOVING BED (SMB); WAVE DYNAMICS;

FLUIDIZED BEDS;

ADSORBENT; DEOXYADENOSINE; DEOXYCYTIDINE; DEOXYGUANOSINE;

ADSORPTION; ARTICLE; CONCENTRATION (PARAMETERS); EFFLUENT; LIQUID CHROMATOGRAPHY; MATHEMATICAL MODEL; SEPARATION TECHNIQUE; SIMULATED MOVING BED CHROMATOGRAPHY;

EID: 41849092593     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826070802022354     Document Type: Article

References (19)

1. Chu, K.H.; Hashim, M.A. Simulated countercurrent adsorption processes: a comparison of modeling strategies. Chem. Eng. J. 1995, 56, 59-65.
2. Mun, S.; Yi, X.; Wang, N.-H.L. Strategies to control batch integrity in size-exclusion simulated moving bed chromatography. Ind. Eng. Chem. Res. 2005, 44, 3268-3283.
3. Hidajat, K.; Ching, C.B.; Ruthuven, D.M. Simulated counter-current adsorption process: a theoretical analysis of the effect of subdividing the adsorbent bed. Chem. Eng. Sci. 1986, 11, 2953-2956.
4. Ma, Z.; Wang, N.-H.L. Standing wave analysis of SMB chromatography: linear systems. AIChE J. 1997, 43, 2488-2508.
5. Beste, Y.A.; Arlt, W. Side-stream simulated moving-bed chromatography for multicomponent separation. Chem. Eng. Technol. 2002, 25, 956-962.
6. Kim, J.K.; Zang, Y.; Wankat, P.C. Single-cascade simulated moving bed systems for the separation of ternary mixtures. Ind. Eng. Chem. Res. 2003, 42, 4849-4860.
7. Wang, X.; Ching, C.B. Chiral separation of β-blocker drug (nadolol) by fivezone simulated moving bed chromatography. Chem. Eng. Sci. 2005, 60, 1337-1347.
8. Hur, J.S.; Wankat, P.C. Hybrid simulated moving bed and chromatography systems for center-cut separation from quaternary mixtures: linear isotherm systems. Ind. Eng. Chem. Res. 2006, 45, 8713-8722.
9. Paredes, G.; Abel, S.; Babler, M.U.; Mazzotti, M.; Morbidelli, M.; Stadler, J. Analysis of a simulated moving bed operation of three fraction separations (3F-SMB). Ind. Eng. Chem. Res. 2004, 43, 6157-6167.
10. Kasat, R.B.; Gupta, S.K. Multi-objective optimization of an industrial fluidized-bed catalytic cracking unit (FCCU) using genetic algorithm (GA) with the jumping genes operator. Comput. Chem. Eng. 2003, 27, 1785-1800.
11. Zhang, Z.; Hidajat, K.; Ray, A.K.; Morbidelli, M. Multiobjective optimization of SMB and varicol process for chiral separation. AIChE J. 2002, 48, 2800-2816.
12. Subramani, H.J.; Hidajat, K.; Ray, A.K. Optimization of simulated moving bed and varicol processes for glucose-fructose separation. Chem. Eng. Res. Des. 2003, 81, 549-567.
13. Zhang, Z.; Mazzotti, M.; Morbidelli, M. Multiobjective optimization of simulated moving bed and varicol processes using a genetic algorithm. J. Chromatogr. A 2003, 989, 95-108.
14. Chung, S.F.; Wen, C.Y. Longitudinal dispersion of liquid flowing through fixed and fluidized beds. AIChE J. 1968, 14, 857-866.
15. Zang, Y.F.; Wankat, P.C. Variable flow rate operation for simulated moving bed separation systems: simulation and optimization. Ind. Eng. Chem. Res. 2003, 42, 4840-4848.
16. Hur, J.S.; Wankat, P.C. New design of simulated moving bed for ternary separations. Ind. Eng. Chem. Res. 2005, 44, 1906-1913.
17. Hur, J.S.; Wankat, P.C. Two zone SMB/chromatography for center-cut separation from ternary mixtures: linear isotherm systems. Ind. Eng. Chem. Res. 2006, 45, 1426-1433.
18. Ergun, S. Flow through packed columns. Chem. Eng. Prog. 1952, 48, 89-94.
19. Mun, S.; Wang, N.-H.L.; Koo, Y.M.; Yi, S.C. Pinched wave design of a four-zone SMB for linear adsorption systems with significant mass transfer effects. Ind. Eng. Chem. Res. 2006, 45, 7241-7250.