Rho kinase is involved in Ca2+ entry of rat penile small arteries

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 4, 2008, Pages

  Villalba, Nuria ^a,b   Stankevicius, Edgaras ^b   Simonsen, Ulf ^b   Prieto, Dolores ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Calcium entry; Calcium sensitization; Nonselective cation channels; Penile arteries

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA TOXIN; BARIUM; CALCIUM; CATION CHANNEL; CYCLOPIAZONIC ACID; FURA 2 ACETOXYMETHYL ESTER; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NIFEDIPINE; NORADRENALIN; POTASSIUM CHLORIDE; PROTEIN KINASE C INHIBITOR; RHO KINASE; RHO KINASE INHIBITOR;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; DEPOLARIZATION; ENZYME ACTIVITY; MALE; MYOGRAPHY; NONHUMAN; PENIS ARTERY; PERMEABILITY; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SENSITIZATION; SMOOTH MUSCLE;

ADRENERGIC ALPHA-AGONISTS; AMIDES; ANIMALS; ARTERIES; BACTERIAL TOXINS; BARIUM; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INDOLES; MALE; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; NIFEDIPINE; NOREPINEPHRINE; PENIS; PHENYLEPHRINE; POTASSIUM CHLORIDE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RHO-ASSOCIATED KINASES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 41749119884     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01221.2007     Document Type: Article

References (36)

1. Albert AP, Large WA. Synergism between inositol phosphates and diacylglycerol on native TRPC6-like channels in rabbit portal vein myocytes. J Physiol 552: 789-795, 2003.
2. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 75: 191-236, 1995.
3. Billups KL. Erectile dysfunction as an early sign of cardiovascular disease. Int J Impot Res 17: S19-S24, 2005.
4. Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, Lewis RL, Mills TM, Hellstrom WJ, Kadowitz PJ. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 101: 9121-9126, 2004.
5. Chitaley K, Bivalacqua TJ, Champion HC, Usta MF, Hellstrom WJ, Mills TM, Webb RC. Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats. Biochem Biophys Res Commun 298: 427-432, 2002.
6. Chitaley K, Wingard CJ, Webb RC, Branan Hm, Stopper VS, Lewis RW, Mills TM. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 7: 119-122, 2001.
7. + channels to RhoA/Rho kinase in pulmonary vasoconstriction. Cardiovasc Res 66: 84-93, 2005.
8. Dietrich A, Chubanov V, Kalwa H, Rost BR, Gudermann T. Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther 112: 744-760, 2006.
9. Ghisdal P, Vandenberg G, Morel N. Rho-dependent kinase is involved in agonist-activated calcium entry in rat arteries. J Physiol 551: 85-867, 2003.
10. Gohla A, Schultz G, Offermanns S. Role for G(12)/G(13) in agonist-induced vascular smooth muscle cell contraction. Circ Res 87: 221-227, 2000.
11. Hill AJ, Hinton JM, Cheng H, Gao Z, Bates DO, Hancox JC, Langton PD, James AF. A TRPC-like non-selective cation current activated by alpha 1-adrenoceptors in rat mesenteric artery smooth muscle cells. Cell Calcium 40: 29-40, 2006.
12. 2+-permeable cation channel. Circ Res 88: 325-332, 2001.
13. 2+ entry by rho-kinase in tracheal smooth muscle. Am J Respir Cell Mol Biol 26: 491-498, 2002.
14. 3 receptor gates store-operated hTrp3 channels. Mol Cell 4: 423-429, 1999.
15. Mita M, Yanaguhara H, Hishinuma S, Saito M, Walsh MP. Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem J 364: 431-440, 2002.
16. Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41: 19-26, 1977.
17. 2+. Circ Res 88: 1283-1290, 2001.
18. Parekh AB, Penner R. Store depletion and calcium influx. Physiol Rev 77: 901-930, 1997.
19. 1-receptor. Br J Pharmacol 129: 1689-1699, 2000.
20. Prieto D, Rivera L, Martínez P, Benedito S, García-Sacristán A, Hernández M. Heterogeneity of the neuropeptide Y (NPY) contractile and relaxing receptors in horse penile small arteries. Br J Pharmacol 143: 976-986, 2004.
21. Prieto D, Rivera L, Recio P, Hernández M, García- Sacristán A. Role of nitric oxide in the relaxations elicited by sildenafil in penile resistance arteries. J Urol 175: 1164-1170, 2006.
22. + channels and ouabain-sensitive mechanisms to the endotheliumdependent relaxations of horse penile small arteries. Br J Pharmacol 123: 1609-1620, 1998.
23. Rees RW, Ralph DJ, Royle M, Moncada S, Cellek S. Y-27632, an inhibitor of Rho-kinase, antagonizes noradrenergic contractions in the rabbit and human penile corpus cavernosum. Br J Pharmacol 133: 455-458, 2001.
24. 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ Res 93: 548-556, 2003.
25. Simonsen U, García-Sacristán A, Prieto D. Penile arteries and erection. J Vasc Res 39: 283-303, 2002.
26. Simonsen U, Prieto D, Hernández M, García- Sacristán A. Adrenoceptor-mediated regulation of the contractility in horse penile resistance arteries. J Vasc Res 34: 90-102, 1997.
27. So I, Chae MR, Kim SJ, Lee SW. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces the change of calcium mobilization via TRPC ion channels in cultured human corporal smooth muscle cells. Int J Impot Res 17: 475-483, 2005.
28. 2+ sensitivity of smooth muscle and non-muscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
29. 2+ sensitivity regulates contractility of rabbit corpus cavernosum smooth muscle. J Urol 169: 2412-2416, 2003.
30. 2+ with quin2. Methods Enzymol 172: 230-263, 1989.
31. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994, 1997.
32. 2+ sensitization of arterial muscle. Am J Physiol Cell Physiol 285: C1377-C1385, 2003.
33. Vickers MA, Wright EA. Erectile dysfunction in the patient with diabetes mellitus. Am J Manag Care 10: S3-S11, 2004.
34. 1-adrenergic vasoconstriction of rat penile small arteries. Am J Physiol Heart Circ Physiol 292: H1157-H1169, 2007.
35. 2+ sensitization in erectile function. J Biol Chem 277, 30614-;-30621, 2002.
36. 2+ release in corpus cavernosum smooth muscle: synergism between nitric oxide and cGMP. Am J Physiol Cell Physiol 288: C650-C658, 2005.