Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes

Toxicology Letters

Volumn 178, Issue 1, 2008, Pages 37-43

  Henkens, Tom ^a   Vinken, Mathieu ^a   Lukaszuk, Aneta ^a   Tourwé, Dirk ^a   Vanhaecke, Tamara ^a   Rogiers, Vera ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Albumin secretion; Connexin; Cytochrome P450; Histone deacetylase inhibitor; Primary hepatocyte

Indexed keywords

5 (4 DIMETHYLAMINOBENZOYL)AMINOVALERIC ACID HYDROXAMIDE; ALBUMIN; AMIDE; CX26 PROTEIN; CX32 PROTEIN; CX43 PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID DERIVATIVE; MITOGENIC AGENT; PROTEIN DERIVATIVE; TRICHOSTATIN A; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLOGY; BIOTRANSFORMATION; CELL CULTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GAP JUNCTION; GENE ACTIVITY; GENE FUNCTION; GENETIC TRANSCRIPTION; HOMEOSTASIS; INTROSPECTION; LIVER; LIVER CELL; LIVER FUNCTION; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TOXICITY; TUMOR CELL; UPREGULATION;

ACETYLATION; ALBUMINS; ANIMALS; CELLS, CULTURED; CONNEXIN 43; CONNEXINS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; EPIDERMAL GROWTH FACTOR; GAP JUNCTIONS; HEPATOCYTES; HISTONE DEACETYLASES; HISTONES; HYDROXAMIC ACIDS; MALE; MITOGENS; PENTANOIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 41749112859     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.02.002     Document Type: Article

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