Modulation of dopaminergic neurotransmission in rat striatum upon in vitro and in vivo diclofenac treatment

Journal of Neurochemistry

Volumn 105, Issue 2, 2008, Pages 360-368

  Milusheva, Elisaveta ^a,b   Baranyi, Mária ^b   Kittel, Agnes ^b   Fekete, Adam ^b   Zelles, Tibor ^b   Vizi, E Sylvester ^b   Sperlágh, Beáta ^b  

^a BULGARIAN ACADEMY OF SCIENCES   (Bulgaria)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Diclofenac; Dopamine release; H2O2; Oxidative stress; Striatum

Indexed keywords

ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; DICLOFENAC; DOPAMINE; HYDROGEN PEROXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OCTOPAMINE; PHENETHYLAMINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SULINDAC; TOLMETIN; TRITIUM; TYRAMINE; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; ENERGY RESOURCE; ENZYME INHIBITION; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; CORPUS STRIATUM; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROGEN PEROXIDE; MALE; OCTOPAMINE; PHENELZINE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TRITIUM; TYRAMINE; TYROSINE 3-MONOOXYGENASE;

RATTUS;

EID: 41749105302     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05141.x     Document Type: Article

References (22)

1. Atkinson D. E. (1968) The energy charge of the adenylate pool as a regulatory parameter: interaction with feedback modifiers. Biochemistry 7, 4030 4034.
2. Baranyi M., Milusheva E., Vizi E. S. Sperlagh B. (2006) Chromatographic analysis of dopamine metabolism in a Parkinsonian model. J. Chromatogr. 1120, 13 20.
3. Bort R., Ponsoda X., Jover R., Gomez-Lechon J. Castell J. V. (1998) Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. JPET 288, 65 72.
4. Branchek T. A. Blackburn T. P. (2003) Trace amine receptors as targets for novel therapeutics: legend, myth and fact. Curr. Opin. Pharmacol. 3, 90 97.
5. Dairam A., Antunes E. M., Saravanan K. S. Daya S. (2006) Non-steroidal anti-inflammatory agents, tolmetin and sulindac, inhibit liver tryptophan 2,3-dioxygenase activity and alter brain neurotransmitter levels. Life Sci. 79, 2269 2274.
6. Dehouck M. P., Jolliet-Riant P., Bree F., Fruchart J. C., Cecchelli R. Tillement J. P. (1992) Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models. J. Neurochem. 58, 1790 1797.
7. Fekete Á., Vizi E. S., Kovács K. J., Lendvai B. Zelles T. (2007) Layer-specific differences in reactive oxygen species levels after oxygen-glucose deprivation in acute hippocampal slices. Free Radic. Biol. Med. M., Kitaichi K., Abe F., Fujimoto Y., Takagi K., Takagi K., Morishima T. Hasewaga T. (2005) Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice. J. Pharmacol. Sci. 97, 525 532.
8. Gomez-Lechon M. J., Ponsoda X., O'Connor E., Donato T., Castell J. V. Jover R. (2003) Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem. Pharmacol. 66, 2155 2167.
9. Hassanein N. M., Hasan W. A. Hamed M. R. (2004) Effects of diclofenac, piroxicam and alpha-tocopherol on monoamine lymphopoietic interfacing in mice. Arzneimittelforschung 54, 847 856.
10. Inoue A., Muranaka S., Fujita H., Kanno T., Tamai H. Utsumi K. (2004) Molecular mechanisms of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, AKT, BID, cytochrome c, and caspase pathway. FRBM 37, 1290 1299.
11. Krause M. M., Brand M. D., Krauss S., Meisel C., Vergin H., Burmester G. R. Buttgereit F. (2003) Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. Arthritis Rheum. 48, 1438 1444.
12. Lindemann L. Hoener M. C. (2005) A renaissance in trace amines inspired by a novel GPCR family. TIPS 26, 274 281.
13. Lowry O. H., Rosebrough N. J., Farr A. L. Randall R. J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265 275.
14. 3H]noradrenaline in response to oxidative stress combined with mitochondrial dysfunction in rat hippocampal slices. Neuroscience 120, 771 781.
15. 2 upon chronic rotenone treatment. Free Radic. Biol. Med. 39, 133 142.
16. Moreno-Sanchez R., Bravo C., Vasquez C., Ayala G., Silveira L. H. Martinez-Lavin M. (1999) Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart. Biochem. Pharmacol. 57, 743 752.
17. Mouithys-Mickalad A. M., Zheng S. X., Deby-Dupont G. P., Lamy M. M., Reginster J. Y. Henrotin Y. E. (2000) In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR). Free Radic. Res. 33, 607 621.
18. Ng L. E., Vincent A. S., Halliwell B. Wong K. P. (2006) Action of diclofenac on kidney mitochondria and cells. Biochem. Biophys. Res. Commun. 348, 494 500.
19. Nikolic D. Van Breemen R. B. (2001) DNA oxidation induced by cyclooxigenase-2. Chem. Res. Toxicol. 14, 351 354.
20. Petrescu I. Tarba C. (1997) Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat. Biochim. Biophys. Acta 1318, 385 394.
21. Sairam K., Saravanan K. S., Banerjee R. Mohanakumar K. P. (2003) Non-steroidal anti-inflammatory drug sodium salicylate, but not diclofenac or celecoxib, protects against 1-methyl-4-pyridinium-induced dopaminergic neurotoxicity in rats. Brain Res. 966, 245 252.
22. Tang Y. Z. Liu Z. Q. (2006) Evaluation of the free-radical-scavenging activity of diclofenac acid on the free-radical-induced haemolysis of human erythrocytes. J. Pharm. Pharmacol. 58, 625 631.