Ethyl glucuronide concentrations in two successive urinary voids from drinking drivers: Relationship to creatinine content and blood and urine ethanol concentrations

Forensic Science International

Volumn 133, Issue 1-2, 2003, Pages 86-94

  Bergstrom J ^a   Helander, A ^a   Jones, A W ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Analysis; Creatinine; Drunk drivers; Ethanol; Ethyl glucuronide; Urine

Indexed keywords

ALCOHOL; CREATININE; GLUCURONIDE;

ADULT; ALCOHOL ABUSE; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; BLOOD ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; DILUTION; DIURESIS; DRUNKEN DRIVING; FEMALE; GAS CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; URINALYSIS; URODYNAMICS;

EID: 0038368000     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(03)00053-7     Document Type: Conference Paper

References (28)

1. Jones A.W. Excretion of alcohol in urine and diuresis in healthy men in relation to their age. Forensic Sci. Int. 45:1990;217-224.
2. A.W. Jones, Forensic science aspects of ethanol metabolism, in: A. Mahley, R.L. Williams (Eds.), Forensic Science Progress, vol. 5, Springer, Berlin, 1991, pp. 33-90.
3. H. Kalant, Pharmacokinetics of ethanol: absorption, distribution, and elimination, in: H. Begleiter, B. Kissin (Eds.), The Pharmacology of Alcohol and Alcohol Dependence, Oxford University Press, Oxford, 1996, pp. 15-58.
4. Kamil I.A., Smith J.N., Williams R.T. A new aspect of ethanol metabolism: isolation of ethyl glucuronide. Biochem. J. 51:1952;32-33.
5. Schmitt G., Aderjan R.E., Keller T., Wu M. Ethyl glucuronide: an unusual ethanol metabolite in humans. Synthesis, analytical data, and determination in serum and urine. J. Anal. Toxicol. 19:1995;91-94.
6. Neubauer O. Über Glukuronsäurepaarung bei Stoffen der Fettreihe. Arch. Exp. Pathol. Pharmacol. 46:1901;133-154.
7. Conti A., Bickel M.H. History of drug metabolism: discoveries of the major pathways in the 19th century. Drug Metab. Rev. 6:1977;1-50.
8. Nishikawa M., Tsuchihashi H., Miki A., Katagi M., Schmitt G., Zimmer H., Keller T., Aderjan R. Determination of ethyl glucuronide, a minor metabolite of ethanol, in human serum by liquid chromatography-electrospray ionization mass spectrometry. J. Chromatogr. B. 726:1999;105-110.
9. Janda I., Alt A. Improvement of ethyl glucuronide determination in human urine and serum samples by solid-phase extraction. J. Chromatogr. B. 758:2001;229-234.
10. Stephanson N., Dahl H., Helander A., Beck O. Direct quantification of ethyl glucuronide in clinical urine samples by liquid chromatography-mass spectrometry. Ther. Drug Monit. 24:2002;645-651.
11. Seidl S., Wurst F.M., Alt A. Ethyl glucuronide - a biological marker for recent alcohol consumption. Addict. Biol. 6:2001;205-212.
12. Schmitt G., Droenner P., Skopp G., Aderjan R. Ethyl glucuronide concentration in serum of human volunteers, teetotalers, and suspected drinking drivers. J. Forensic Sci. 42:1997;1099-1102.
13. Dahl H., Stephanson N., Beck O., Helander A. Comparison of urinary excretion characteristics of ethanol and ethyl glucuronide. J. Anal. Toxicol. 26:2002;201-204.
14. A. Helander, A.W. Jones, Biochemical tests for acute and chronic alcohol ingestion, in: S. Karch (Ed.), Drug Abuse Handbook, CRC Press, Boca Raton, 1998, pp. 374-394.
15. Schmitt G., Drönner P., Aderjan R., Skopp G. Blutprobe mit 1.44 Promille Ethanol enthielt kein Ethylglucuronid - Fallbericht. Blutalkohol. 34:1997;371-378.
16. Bendtsen P., Jones A.W., Helander A. Urinary excretion of methanol and 5-hydroxytryptophol as biochemical markers of recent drinking in the hangover state. Alcohol. 33:1998;431-438.
17. Jones A.W., Eklund A., Helander A. Misleading results of ethanol analysis in urine specimens from rape victims suffering from diabetes. J. Clin. Forensic Med. 7:2000;144-146.
18. Droenner P., Schmitt G., Aderjan R., Zimmer H. A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans. Forensic Sci. Int. 126:2002;24-29.
19. Jones A.W. Top-ten defense challenges among drinking drivers in Sweden. Med. Sci. Law. 31:1991;229-238.
20. Jones A.W., Schuberth J. Computer-aided headspace gas chromatography applied to blood-alcohol analysis: importance of on-line process control. J. Forensic Sci. 34:1989;1116-1127.
21. Cook J.D., Caplan Y.H., LoDico C.P., Bush D.M. The characterization of human urine for specimen validity determination in workplace drug testing: a review. J. Anal. Toxicol. 24:2000;579-588.
22. M. Bland, An Introduction to Medical Statistics, 3rd ed., Oxford University Press, Oxford, 2000.
23. O'Neal C.L., Poklis A. Postmortem production of ethanol and factors that influence interpretation: a critical review. Am. J. Forensic Med. Pathol. 17:1996;8-20.
24. Jones A.W. Reference limits for urine/blood ratios of ethanol in two successive voids from drinking drivers. J. Anal. Toxicol. 26:2002;333-339.
25. Jones A.W. Lack of association between urinary creatinine and ethanol concentrations and urine/blood ratios of ethanol in two successive voids from drinking drivers. J. Anal. Toxicol. 22:1998;184-190.
26. Bendtsen P., Jones A.W. Impact of water-induced diuresis on urine-ethanol profiles, urine-creatinine, and urine-osmolality. J. Anal. Toxicol. 23:1999;565-569.
27. Goll M., Schmitt G., Ganssmann B., Aderjan R. Excretion profiles of ethyl glucuronide in human urine after internal dilution. J. Anal. Toxicol. 26:2002;262-266.
28. Zimmer H., Schmitt G., Aderjan R. Preliminary immunochemical test for the determination of ethyl glucuronide in serum and urine: comparison of screening method results with gas chromatography-mass spectrometry. J. Anal. Toxicol. 26:2002;11-16.