Different patterns of cyclin D1/CDK4-E2F-1/4 pathways in human embryo lung fibroblasts treated by benzo[a]pyrene at different doses

Biomedical and Environmental Sciences

Volumn 21, Issue 1, 2008, Pages 30-36

  Ye, Meng ^a   Liu, Bing Ci ^a   Shi, Xiang Lin ^b   You, Bao Rong ^a   Du, Hong Ju ^a   Jia, Xiao Wei ^a   Shen, Fu Hai ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Benzo a pyrene; CDK4; Cell cycle; Cyclin D1; E2F

Indexed keywords

EID: 41649114811     PISSN: 08953988     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-3988(08)60004-5     Document Type: Article

References (26)

1. Tokiwa H, Sera N, Horikawa K, et al. (1993). The presence of mutagens/carcinogens in the excised lung and analysis of lung cancer induction. Carcinogenesis 14, 1933-1938.
2. Ruggeri B, Dirado M, Zhang S Y, et al. (1993). Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc Natl Acad Sci USA 90, 1013-1017.
3. Serpi R, Vahakangas K (2003). Benzo(a)pyrene-induced changes in p53 and related proteins in mouse skin. Pharm Toxicol 92, 242-245.
4. Nesnow S, Tennant C H, Nelson G B, et al. (2002). Comparison of the genotoxic activities of the K-region dihydrodiol of benzo[a]pyrene with benzo[a]pyrenein mammalian cells: morphological cell transformation; DNA damage; and stable covalent DNA adducts. Mutat Res 521, 91-102.
5. Alt J, Cleveland J L, Hannink M, et al. (2000). Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev 14, 3102-3114.
6. 1 in cell cycle control. J Biol Chem 275, 30520-30524.
7. Trimarchi J M, Lees J A (2002). Sibling rivalry in the E2F family. Mol Cell Biol 3, 11-20.
8. Gregori J D (2002). The genetics of the E2F family of transcription factors: shared functions and unique roles. BBA 1602, 131-150.
9. Levine A J (1997). P53, the cellular gatekeeper for growth and division. Cell 88, 323-331.
10. Ko L J, Prives C (1996). P53: puzzle and paradigm. Genes Dev 10, 1054-1072.
11. Vaziri C, Faller D V (1997). A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts. J Biol Chem 272, 2762-2769.
12. Guo N, Faller D V, Vaziri C (2002). Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell Growth Differ 13, 77-86.
13. Wang A, Gu J, Kremer K J, et al. (2003). Response of human mammary epithelial cells to DNA damage induced by BPDE: involvement of novel regulatory pathways. Carcinogenesis 24, 225-234.
14. Guo N, Faller D V, Vaziri C (2000). A novel DNA damage checkpoint involving post-transcriptional regulation of cyclin A expression. J Biol Chem 275, 1715-1722.
15. Yan K X, Liu B C, Xu M, et al. (2003). Recombination and identification of sense and antisense cyclin D1 eukaryotic expression vectors. J Hygiene Res 32, 180-182.
16. Petruzzelli S, Celi A, Pulera N, et al. (1998). Serum antibodies to benzo(a)pyrene diol epoxide-DNA adducts in the general population: Effects of air pollution, tobacco smoking, and family history of lung diseases. Cancer Res 58, 4122-4126.
17. Zhou B S, Elledge S J (2000). The DNA damage response: Putting checkpoints in perspective. Nature 408, 433-439.
18. Khan Q A, Dipple A (2000). Diverse chemical carcinogens fail to induce G1 arrest in MCF-7 cells. Carcinogenesis 21, 1611-1618.
19. Pliskova M, Vondracek J, Vojtesek B, et al. (2005). Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events. Toxic Sci 83, 246-256.
20. Johnson D G, Coleman A, Powell K L, et al. (1997) High-affinity binding of the cell cycle-regulated transcription factors E2F1 and E2F4 to benzo[a]pyrene diol epoxide-DNA adducts. Mol Cardnog 20, 216-223.
21. Cam H, Dynlachi B D (2003). Emerging roles for E2F: Beyond the G1/S transition and DNA replication. Cancer Cell 3, 311-316.
22. Cheng M, Olivier P, Diehl A, et al. (1999). The p21Cip1 and p27Kip1 CDK inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J 18, 1571-1583.
23. Sherr C J, Roberts J M (1995). Inhibitors of mammalian G1 cyclin-dependentkinases. Genes Dev 9, 1149-1163.
24. Diehl J A, Zindy F, Sherr C J (1997). Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathwey. Genes Dev 11, 957-972.
25. Zhang S Y, Liu S C, Goodrow T, et al. (1997). Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms. Mol Carcinog 18, 142-152.
26. Knezevic D, Brash D E (2004). Role of E2F-1 in apoptosis: A case study in feedback loops. Cell Cycle 3, 729-732.