Increased expression of G1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms

Molecular Carcinogenesis

Volumn 18, Issue 3, 1997, Pages 142-152

  Zhang, Shi Yu ^a   Liu, Shao Chen ^a   Goodrow, Tamra ^a   Morris, Rebecca ^b   Klein Szanto, Andres J P ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

Author keywords

Cdk; Chemical carcinogenesis; Cyclin; Mouse skin tumors; Tumor progression

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; BENZO[A]PYRENE; CYCLIN DEPENDENT KINASE; CYCLINE; CARCINOGEN; CCND2 PROTEIN, MOUSE; CYCLIN D1; CYCLIN D3; ONCOPROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHEMICALLY INDUCED DISORDER; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; METABOLISM; PAPILLOMA; PATHOLOGY;

ANIMALIA;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; BENZO(A)PYRENE; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CYCLIN D1; CYCLIN-DEPENDENT KINASES; CYCLINS; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; IMMUNOHISTOCHEMISTRY; MICE; ONCOGENE PROTEINS; PAPILLOMA; S PHASE; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE;

EID: 0030611070     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199703)18:3<142::AID-MC3>3.0.CO;2-H     Document Type: Article

References (47)

1. Morgan DO. Principles of Cdk regulation. Nature 374:131-134, 1995.
2. Hunter T, Pines J. Cyclins and cancer II: Cyclin D and Cdk inhibitors come of age. Cell 79:573-583, 1994.
3. Kamb A, Gruis NA, Weaver-Feldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436-440, 1994.
4. Lammie GA, Fantl JC, Smith R, et al. D115287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to Bcl-1. Oncogene 6:439-444, 1991.
5. Jiang W, Zhang Y-J, Kahn SM, Hollstein MC, et al. Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc Natl Acad Sci USA 90:9026-9030, 1993.
6. Weinstat-Saslow D, Merino MJ, Manrow RE, et al. Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nat Med 12:1257-1260, 1995.
7. Bartkova J, Lukas J, Strauss M, Bartek J. Cyclin D1 oncoprotein aberrantly accumulates in malignancies of diverse histogenesis. Oncogene 10:775-778, 1995.
8. Meyerson M, Harlow E. Identification of G1 kinase activity for Cdk6, a novel cyclin D partner. Mol Cell Biol 14:2077-2086, 1994.
9. Bates S, Parry D, Binetta L, et al. Absence of cyclin D/Cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9:1633-1640, 1994.
10. Reifenberger G, Reifenberger J, Ichimura K, et al. Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: Preliminary mapping of the amplicons show preferential involvement of Cdk4, SAS and MDM2. Cancer Res 54:4299-4303, 1994.
11. Schmidt EE, Ichimura K, Reifenberger G, et al. CdkN2 (p16/ MTST1) gene deletion on Cdk4 amplification occurs in the majority of glioblastomas. Cancer Res 54:6321-6324, 1994.
12. Khatib ZA, Matsushime H, Valentine M, et al. Co-amplification of the Cdk4 gene with MDM2 and GL1 in human sarcomas. Cancer Res 53:5535-5541, 1993.
13. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/Cdk4. Nature 366:704-707, 1993.
14. Mori T, Miura K, Aoki T, et al. Frequent somatic mutation of the MTS1/Cdk4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Res 54:3396-3397, 1994
15. Zhang S-Y, Klein-Szanto AJP, Sauter ER, et al. Higher frequency of alteration in the p16/CdkN2 gene in squamous cell carcinoma lines than in primary tumors of the head and neck. Cancer Res 54:5050-5053, 1994.
16. INK4b in undifferentiated mouse skin tumors. Cancer Res 55:5168-5172, 1995.
17. Bianchi AB, Fischer SM, Robles AI. Overexpression of cyclin D1 in mouse skin carcinogenesis. Oncogene 8:1127-1133, 1993.
18. Robles A, Conti J. Early overexpression of cyclin D protein in mouse skin carcinogenesis. Carcinogenesis 16:781-786, 1995.
19. Ruggeri B, Caamano J, Goodrow T, et al. Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res 51:6615-6621, 1991.
20. Ruggeri BA, Bauer B, Zhang S-Y, Klein-Szanto AJP. Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo(a)pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cydin D1 abnormalities. Carcinogenesis 15:1613-1619, 1994.
21. Morris R. Mouse epidermal cultures. In: The Keratinocyte Handbook, Cambridge University Press, Cambridge, 1994, pp 53-69.
22. Ruggeri B, DiRado M, Zhang SY, Bauer B, Goodrow T, Klein-Szanto AJP. Benzo(a)pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene. Proc Natl Acad Sci USA 90:1013-1017, 1993.
23. Harlow E, Lane D. Antibodies, A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1988.
24. Jiang W, Kahn SM, Zhou P, et al. Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression. Oncogene 8:3447-3457, 1993.
25. Wang TC, Cardiff RD, Zukenberg L, et al. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 669-671, 1994.
26. Mitsunaga SI, Zhang SY, Ruggeri BA, et al. Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo(a)pyrene. Carcinogenesis 16:1629-1635, 1995.
27. Lovec H, Sewing A, Lucibello FC, Muller R, Moroy T. Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: Link between cell cycle control and malignant transformation. Oncogene 9:323-326, 1994.
28. Robles AI, Larcher F, Whalin RB, et al. Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia. Proc Natl Acad Sci USA, 97:7634-7638, 1996.
29. Quelle DE, Ashmun RA, Shurtleffs SA, et al. Overexpression of mouse b-type cyclins accelerate G1 phase in rodent fibroblasts. Genes Dev 7:1559-1571, 1993.
30. Leach FS, Elledge SJ, Sherr CJ, et al. Amplification of cyclin D genes in colorectal carcinomas. Cancer Res 53:1986-1989, 1993.
31. Hanna Z, Jankowski M, Tremblay P, et al. The vin-1 gene, identified by provirus intentional mutagenesis, is the cyclin D2. Oncogene 8:1661-1666, 1993.
32. Bartkova J, Zemanova M, Bartek J. Abundance and subcellular localization of cyclin D3 in human tumors. Int J Cancer 65:323-327, 1996.
33. Sherr CJ. Mammalian G1 cyclins. Cell 73:1059-1065, 1993.
34. Said TK, Medina D. Cell cyclins and cyclin-dependent kinase activities in mouse mammary tumor development. Carcinogenesis 16:823-830, 1995.
35. Keyomarsi K, O'Leary N, Molnar G, et al. Cyclin E, a potential prognostic marker for breast cancer. Cancer Res 54:380-385, 1994.
36. Keyomarsi K, Conte D Jr, Toyofuku W, Fox MP. Deregulation of cyclin E in breast cancer. Oncogene 11:941-950, 1995.
37. Kip1. Cancer Res 56:1389-1399, 1996.
38. Kitahara K, Yasui W, Kuniyasu H, et al. Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas. Int J Cancer 62:25-28, 1995.
39. Fukuda M, Okamura K, Rohrbrach R, Bohm N, Fujita S. Changes in cell population kinetics during epidermal Carcinogenesis. Cell Tissue Kinet 11:611-621, 1978.
40. Filmus J, Robles AI, Shi W, Wong MJ, Colombo LL, Conti CJ. Induction of cyclin D1 overexpression by activated ras. Oncogene 9:3627-3633, 1994.
41. Sgambato A, Han EK, Zhang Y-J, Moon RC, Santella RM, Weinstein IB. Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors. Carcinogenesis 16:2193-2198, 1995.
42. Buchmann A, Ruggeri B, Klein-Szanto AJP, Balmain A. Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res 51:4097-4101, 1991.
43. Iwasaki T, Shinkai K, Mukai M, et al. Cell-cycle-dependent invasion in vitro by rat ascites hepatoma cells. Int J Cancer 63:282-287, 1995.
44. Wolowiec D, Benchaib M, Pernas P, et al. Expression of cell cycle regulatory proteins in chronic lymphocytic leukemias: Comparison with non-Hodgkin's lymphomas and non-neoplastic lymphoid tissue. Leukemia 9:1382-1388, 1995.
45. Yamamoto H, Monden T, Ikeda K, et al. Co-expression of Cdk2/ cdc2 and retinoblastoma gene products in colorectal cancer. Br J Cancer 71:1231-1236, 1995.
46. Nevins JR. A link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429, 1992.
47. Weinberg RA. Tumor suppressor genes. Science 254:1138-1146, 1991.