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DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents, A working group of the Office of AIDS Research Advisory Council OARAC, Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents, Published October 10, 2006. Accessed September 10, 2007
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DHHS Panel on Antiretroviral Guidelines for Adults and Adolescents - A working group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. http://www.aidsinfo.nih.gov./guidelines/guidelinedetail.aspx? menuitem=guidelines&search=off&guidelineid=7&classid=1. Published October 10, 2006. Accessed September 10, 2007.
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Chemokine receptors as HIV-1 coreceptors: Roles in viral Entry, tropism, and disease
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NIAID-Division of AIDS HIV/OI/TB therapeutics database, Accessed September 10, 2007
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NIAID-Division of AIDS HIV/OI/TB therapeutics database. http://chemdb2.niaid.nih.gov/struct_search/all/url_search.asp?aids_no=104834. Accessed September 10, 2007.
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7
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30744447460
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Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
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Fätkenheuer G, Pozniak AL, Johnson MA, et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med. 2005;11:1170-1172.
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Nat Med
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Fätkenheuer, G.1
Pozniak, A.L.2
Johnson, M.A.3
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8
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35649011345
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New agents and new paradigms: The complexity of CCRS inhibition
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Presented at: February 25-28, Los Angeles, CA. Abstract 108
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Kuritzkes D. New agents and new paradigms: The complexity of CCRS inhibition. Presented at: 14th Conference on Retroviruses and Opportunistic Infections; February 25-28, 2007; Los Angeles, CA. Abstract 108.
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(2007)
14th Conference on Retroviruses and Opportunistic Infections
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Kuritzkes, D.1
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9
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33646718378
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A genotypic analysis of HIV-1 sequences from emerging resistant virus after in vitro serial passage with the CCR5 antagonist maraviroc (UK-427857)
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Presented at: March 30-April 1, Athens, Greece. Abstract 91
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Lewis M, Westby M, Smith-Burchnell C, Mori J, Whitcomb J, Perros M. A genotypic analysis of HIV-1 sequences from emerging resistant virus after in vitro serial passage with the CCR5 antagonist maraviroc (UK-427857). Presented at: Third European HIV Drug Resistance Workshop; March 30-April 1, 2005; Athens, Greece. Abstract 91.
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(2005)
Third European HIV Drug Resistance Workshop
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Lewis, M.1
Westby, M.2
Smith-Burchnell, C.3
Mori, J.4
Whitcomb, J.5
Perros, M.6
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10
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33847237614
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Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
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Westby M, Smith-Burchnell C, Mori J, et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J Virol. 2007;81:2359-2371.
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J Virol
, vol.81
, pp. 2359-2371
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Westby, M.1
Smith-Burchnell, C.2
Mori, J.3
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11
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35549003416
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Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2
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Mori J, Mosley M, Lewis M, et al. Characterization of maraviroc resistance in patients failing treatment with CCR5-tropic virus in MOTIVATE 1 and MOTIVATE 2. Antivir Ther. 2007;12:S12.
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(2007)
Antivir Ther
, vol.12
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Mori, J.1
Mosley, M.2
Lewis, M.3
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12
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33646443202
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Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
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Wesfby M, Lewis M, Whitcomb J, et al. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol. 2006;80:4909-4920.
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(2006)
J Virol
, vol.80
, pp. 4909-4920
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Wesfby, M.1
Lewis, M.2
Whitcomb, J.3
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13
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CXCR4-using virus detected in patients receiving maraviroc in the phase III studies MOTIVATE 1 and 2 originates from a pre-existing minority of CXCR4-using virus
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Lewis M, Simpson P, Fransen S, et al. CXCR4-using virus detected in patients receiving maraviroc in the phase III studies MOTIVATE 1 and 2 originates from a pre-existing minority of CXCR4-using virus. Antivir Ther. 2007;12:S65.
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(2007)
Antivir Ther
, vol.12
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Lewis, M.1
Simpson, P.2
Fransen, S.3
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14
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0012834233
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Pharmacokinetics of single and multiple oral doses of UK-427,857 - A novel CCR5 antagonist in healthy volunteers. Poster
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presented at: February 10-14, Boston, MA. Abstract 547
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Abel S, van der Ryst E, Muirhead GJ, Rosario M, Edgington A, Weissgerber G. Pharmacokinetics of single and multiple oral doses of UK-427,857 - A novel CCR5 antagonist in healthy volunteers. Poster presented at: 10th Conference on Retroviruses and Opportunistic Infections; February 10-14, 2003. Boston, MA. Abstract 547.
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(2003)
10th Conference on Retroviruses and Opportunistic Infections
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Abel, S.1
van der Ryst, E.2
Muirhead, G.J.3
Rosario, M.4
Edgington, A.5
Weissgerber, G.6
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15
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9744254946
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Evaluation of dosing frequency and food effect on viral load reduction during short-term monotherapy with UK-427,857 a novel CCR5 antagonist
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Presented at:, July 11-16, Bangkok, Thailand. Abstract TuPeB4489
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Fätkenheuer G, Pozniak AL, Johnson M, et al. Evaluation of dosing frequency and food effect on viral load reduction during short-term monotherapy with UK-427,857 a novel CCR5 antagonist. Presented at: The XV International AIDS Conference, 2004; July 11-16, 2004; Bangkok, Thailand. Abstract TuPeB4489.
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(2004)
The XV International AIDS Conference
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Fätkenheuer, G.1
Pozniak, A.L.2
Johnson, M.3
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16
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35648955546
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Comparison of the pharmacokinetics of maraviroc (UK-427,857) in healthy Asian and Caucasian subjects
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Presented at: April 28-30, Quebec, Canada. Abstract 41
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Russell D, Ridgway C, Taylor-Worth R, Weissgerber G, Tan Y, Muirhead G. Comparison of the pharmacokinetics of maraviroc (UK-427,857) in healthy Asian and Caucasian subjects. Presented at: 6th International Workshop on Clinical Pharmacology of HIV Therapy; April 28-30, 2005; Quebec, Canada. Abstract 41.
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(2005)
6th International Workshop on Clinical Pharmacology of HIV Therapy
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Russell, D.1
Ridgway, C.2
Taylor-Worth, R.3
Weissgerber, G.4
Tan, Y.5
Muirhead, G.6
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17
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15344350690
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Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV
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Walker DK, Abel S, Comby P, et al. Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV. Drug Metab Dispos. 2005;33:587-595.
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(2005)
Drug Metab Dispos
, vol.33
, pp. 587-595
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Walker, D.K.1
Abel, S.2
Comby, P.3
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18
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27644510382
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Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
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Dorr P, Westby M, Dobbs S, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 2005;49:4721-4732.
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(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4721-4732
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Dorr, P.1
Westby, M.2
Dobbs, S.3
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19
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3543092371
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Effect of CYP3A4 inhibitors on the pharmacokinetics of CCR5 antagonist UK-427,857 in healthy volunteers
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April 1-3, Rome, Italy. Poster 5.8
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Abel S, Russell D, Ridgway C, Medhurts C, Weissgerber G, Muirhead G. Effect of CYP3A4 inhibitors on the pharmacokinetics of CCR5 antagonist UK-427,857 in healthy volunteers. Poster presented at: 5th International Workshop on Clinical Pharmacology of HIV Therapy; April 1-3, 2004; Rome, Italy. Poster 5.8.
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(2004)
Poster presented at: 5th International Workshop on Clinical Pharmacology of HIV Therapy
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Abel, S.1
Russell, D.2
Ridgway, C.3
Medhurts, C.4
Weissgerber, G.5
Muirhead, G.6
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20
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33749839996
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Safety and efficacy of maraviroc (MVC), a novel CCR5 antagonist, when used in combination with optimized background therapy (OBT) for the treatment of antiretrovirai-experienced subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial
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Presented at: August 13-18, Toronto, Canada. Abstract THLB0215
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Mayer H, van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc (MVC), a novel CCR5 antagonist, when used in combination with optimized background therapy (OBT) for the treatment of antiretrovirai-experienced subjects infected with dual/mixed-tropic HIV-1: 24-week results of a phase 2b exploratory trial. Presented at: XVI International AIDS Conference; August 13-18, 2006; Toronto, Canada. Abstract THLB0215.
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(2006)
XVI International AIDS Conference
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Mayer, H.1
van der Ryst, E.2
Saag, M.3
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21
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35648936336
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Selective suppression of R5 HIV-1 by the novel CCR5 antagonist maraviroc (MVC) is associated with maintenance of CD4 counts in antiretroviral-experienced patients (pts) infected with dual/mixed tropic (D/M) HIV-1
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Presented at: November 12-16, Glasgow, UK. Abstract 286
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van der Ryst E, Mayer H, Goodrich JM, et al. Selective suppression of R5 HIV-1 by the novel CCR5 antagonist maraviroc (MVC) is associated with maintenance of CD4 counts in antiretroviral-experienced patients (pts) infected with dual/mixed tropic (D/M) HIV-1. Presented at: Eighth International Congress on Drug Therapy in HIV Infection; November 12-16, 2006; Glasgow, UK. Abstract 286.
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(2006)
Eighth International Congress on Drug Therapy in HIV Infection
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van der Ryst, E.1
Mayer, H.2
Goodrich, J.M.3
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22
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34249089383
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Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/3 study in the US and Canada
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Presented at: February 25-28, Los Angeles, CA. Abstract 104bLB
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Lalezari J, Goodrich J, DeJesus E, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic ART-experienced patients infected with CCR5-tropic HIV-1: 24-week results of a phase 2b/3 study in the US and Canada. Presented at: 14th Conference on Retroviruses and Opportunistic Infections; February 25-28, 2007; Los Angeles, CA. Abstract 104bLB.
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(2007)
14th Conference on Retroviruses and Opportunistic Infections
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Lalezari, J.1
Goodrich, J.2
DeJesus, E.3
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23
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34249075565
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Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-week results
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Presented at: February 25-28, Los Angeles, CA. Abstract 104aLB
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Nelson M, Fätkenheuer G, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in viremic, ART-experienced patients infected with CCR5-tropic HIV-1 in Europe, Australia, and North America: 24-week results. Presented at: 14th Conference on Retroviruses and Opportunistic Infections; February 25-28, 2007; Los Angeles, CA. Abstract 104aLB.
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(2007)
14th Conference on Retroviruses and Opportunistic Infections
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Nelson, M.1
Fätkenheuer, G.2
Konourina, I.3
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24
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35648969926
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Efficacy and safety of once-daily (QD) compared with twice-daily (BID) maraviroc plus optimized background therapy (OBT) in treatment-experienced patients infected with CCR5-tropic-HIV-1: 24-week combined analysis of the MOTIVATE 1 and 2 studies
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Presented at: July 22-25, Sydney, Australia. Abstract WEPEB116LB
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Gulick R, van der Ryst E, Lampiris H, et al. Efficacy and safety of once-daily (QD) compared with twice-daily (BID) maraviroc plus optimized background therapy (OBT) in treatment-experienced patients infected with CCR5-tropic-HIV-1: 24-week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007. Sydney, Australia. Abstract WEPEB116LB.
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(2007)
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
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Gulick, R.1
van der Ryst, E.2
Lampiris, H.3
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25
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35648997355
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Efficacy of maraviroc in combination with at least one other potent new antiretroviral drug: 24-week combined analysis of MOTIVATE 1 and 2 studies
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Presented at: July 22-25, Sydney, Australia. Abstract WEPEB115LB
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van der Ryst E, Cooper D, Konourina I, et al. Efficacy of maraviroc in combination with at least one other potent new antiretroviral drug: 24-week combined analysis of MOTIVATE 1 and 2 studies. Presented at: 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB115LB.
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(2007)
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
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van der Ryst, E.1
Cooper, D.2
Konourina, I.3
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26
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A multicenter, randomized, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive patients with R5 HIV 1: Week 48 results of the MERIT study
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Presented at: July 22-25, Sydney, Australia. Abstract WESS104
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Saag M, Ive P, Heera J, et al. A multicenter, randomized, comparative trial of a novel CCR5 antagonist, maraviroc versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive patients with R5 HIV 1: Week 48 results of the MERIT study. Presented at: 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WESS104.
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(2007)
4th IAS Conference on HIV Pathogenesis, Treatment and Prevention
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Saag, M.1
Ive, P.2
Heera, J.3
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27
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35649004259
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A single dose study to investigate the effect of the CCR5 antagonist maraviroc (UK-427,857) on the QTc interval in healthy subjects
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July 11-16, Bangkok, Thailand. Poster 3.5
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Davis J, Hackman F, Sudworth D, Weissgerber G. A single dose study to investigate the effect of the CCR5 antagonist maraviroc (UK-427,857) on the QTc interval in healthy subjects. Poster presented at: The XV International AIDS Conference, 2004; July 11-16,2004; Bangkok, Thailand. Poster 3.5.
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(2004)
Poster presented at: The XV International AIDS Conference
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Davis, J.1
Hackman, F.2
Sudworth, D.3
Weissgerber, G.4
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28
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34547233873
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Investigation into the haemodynamic effects of oral maraviroc (UK-427,857) in healthy volunteers. Poster
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presented at: November 17-20, Dublin, Ireland. Abstract LBPE4
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Russell D, Weissgerber G, Wooldridge C, Ridgway C, Abel S, Muirhead G. Investigation into the haemodynamic effects of oral maraviroc (UK-427,857) in healthy volunteers. Poster presented at: 10th European AIDS Conference/EACS; November 17-20, 2005; Dublin, Ireland. Abstract LBPE4.1/10.
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(2005)
10th European AIDS Conference/EACS
, pp. 1-10
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Russell, D.1
Weissgerber, G.2
Wooldridge, C.3
Ridgway, C.4
Abel, S.5
Muirhead, G.6
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29
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33144464597
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Overview of the drug-drug interaction data for maraviroc (UK-427,857)
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Presented at: April 28-30, Quebec, Canada. Abstract 76
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Abel S, Russell D, Ridgway C, Muirhead G. Overview of the drug-drug interaction data for maraviroc (UK-427,857). Presented at: 6th International Workshop on Clinical Pharmacology of HIV Therapy; April 28-30, 2005; Quebec, Canada. Abstract 76.
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(2005)
6th International Workshop on Clinical Pharmacology of HIV Therapy
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Abel, S.1
Russell, D.2
Ridgway, C.3
Muirhead, G.4
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30
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35648980410
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April 1-3, Rome, Italy. Poster 5.9
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Hyland R, Jones B, Muirhead G. In vitro assessment of the CYP-based drug-drug interaction potential of UK-427,857. Poster presented at: 5th International Workshop on Clinical Pharmacology of HIV Therapy; April 1-3, 2004; Rome, Italy. Poster 5.9.
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(2004)
vitro assessment of the CYP-based drug-drug interaction potential of UK-427,857. Poster presented at: 5th International Workshop on Clinical Pharmacology of HIV Therapy
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Hyland, R.1
Jones, B.2
Muirhead, G.3
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31
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3543092371
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The effect of P450 inducers on the pharmacokinetics of CCR5 antagonist, UK-427,857
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April 1-3, Rome, Italy. Paper 5.4
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Jenkins T, Abel S, Russell D, et al. The effect of P450 inducers on the pharmacokinetics of CCR5 antagonist, UK-427,857, in healthy volunteers. Presented at: 5th International Workshop on Clinical Pharmacology of HIV Therapy; April 1-3, 2004; Rome, Italy. Paper 5.4.
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(2004)
healthy volunteers. Presented at: 5th International Workshop on Clinical Pharmacology of HIV Therapy
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Jenkins, T.1
Abel, S.2
Russell, D.3
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32
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33845688834
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An investigation of the effects of tenofovir on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857
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Presented at: November 14-17, Glasgow, UK. Abstract P282
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Muirhead G, Russell D, Abel S, et al. An investigation of the effects of tenofovir on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857. Presented at: Seventh International Congress on Drug Therapy in HIV Infection; November 14-17, 2004; Glasgow, UK. Abstract P282.
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(2004)
Seventh International Congress on Drug Therapy in HIV Infection
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Muirhead, G.1
Russell, D.2
Abel, S.3
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33
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35649022566
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A study to investigate the combined co-administration of P450 CYP3A4 inhibitors and inducers on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857
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Presented at: November 14-17, Glasgow, UK. Abstract P284
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Muirhead G, Ridgway C, Leahy D, Mills C, van der Merwe R, Russell D. A study to investigate the combined co-administration of P450 CYP3A4 inhibitors and inducers on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857. Presented at: Seventh International Congress on Drug Therapy in HIV Infection; November 14-17, 2004; Glasgow, UK. Abstract P284.
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(2004)
Seventh International Congress on Drug Therapy in HIV Infection
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Muirhead, G.1
Ridgway, C.2
Leahy, D.3
Mills, C.4
van der Merwe, R.5
Russell, D.6
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34
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33845688834
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An investigation of the effects of atazanavir and ritonavir boosted atazanavir on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857
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Presented at: November 14-17, Glasgow, UK. Abstract P283
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Muirhead G, Abel S, Russell D, et al. An investigation of the effects of atazanavir and ritonavir boosted atazanavir on the pharmacokinetics of the novel CCR5 inhibitor UK-427,857. Presented at: Seventh International Congress on Drug Therapy in HIV Infection; November 14-17, 2004; Glasgow, UK. Abstract P283.
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(2004)
Seventh International Congress on Drug Therapy in HIV Infection
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Muirhead, G.1
Abel, S.2
Russell, D.3
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35
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34547171385
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Effect of boosted tipranavir on the pharmacokinetics of maraviroc (UK 427,857) in healthy volunteers
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November 17-20, Dublin, Ireland. Abstract LBPE4
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Abel S, Taylor-Worth R, Ridgway C, Weissgerber G, Kraft M. Effect of boosted tipranavir on the pharmacokinetics of maraviroc (UK 427,857) in healthy volunteers. Poster presented at: 10th European AIDS Conference/EACS; November 17-20, 2005; Dublin, Ireland. Abstract LBPE4.3/15.
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(2005)
Poster presented at: 10th European AIDS Conference/EACS
, pp. 3-15
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Abel, S.1
Taylor-Worth, R.2
Ridgway, C.3
Weissgerber, G.4
Kraft, M.5
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36
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34548297381
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A novel probe drug interaction study to investigate the effect of selected ARV combinations on the pharmacokinetics of a single oral dose of maraviroc (UK-427,857) in HTV+ve subjects
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April 28-30, Quebec, Canada. Poster 2.19
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Muirhead G, Pozniak A, Boffito M, et al. A novel probe drug interaction study to investigate the effect of selected ARV combinations on the pharmacokinetics of a single oral dose of maraviroc (UK-427,857) in HTV+ve subjects. Poster presented at: 6th International Workshop on Clinical Pharmacology of HIV Therapy; April 28-30, 2005; Quebec, Canada. Poster 2.19.
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(2005)
Poster presented at: 6th International Workshop on Clinical Pharmacology of HIV Therapy
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Muirhead, G.1
Pozniak, A.2
Boffito, M.3
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37
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35649016542
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The effect of maraviroc (UK-427,857) on the pharmacokinetics of 3TC/AZT (combivir) in healthy subjects
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Presented at: April 28-30, Quebec, Canada. Poster 2.23
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Muirhead G, Abel S, Hackman F, Whitlock L, van der Merwe R, Russell D. The effect of maraviroc (UK-427,857) on the pharmacokinetics of 3TC/AZT (combivir) in healthy subjects. Presented at: 6th International Workshop on Clinical Pharmacology of HIV Therapy; April 28-30, 2005; Quebec, Canada. Poster 2.23.
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(2005)
6th International Workshop on Clinical Pharmacology of HIV Therapy
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Muirhead, G.1
Abel, S.2
Hackman, F.3
Whitlock, L.4
van der Merwe, R.5
Russell, D.6
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38
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22244486859
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Effect of UK-427,857, on the pharmacokinetics of oral contraceptive steroids, and the pharmacokinetics of UK-427,857 in healthy young women
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Presented at: September 14-17, Chicago, IL. Abstract
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Abel S, Whitlock L, Ridgway C, Saifulanwar A, Bakhtyari A, Russell D. Effect of UK-427,857, on the pharmacokinetics of oral contraceptive steroids, and the pharmacokinetics of UK-427,857 in healthy young women. Presented at: 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy; September 14-17, 2003; Chicago, IL. Abstract A-1619.
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(2003)
43rd Interscience Conference on Antimicrobial Agents and Chemotherapy
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Abel, S.1
Whitlock, L.2
Ridgway, C.3
Saifulanwar, A.4
Bakhtyari, A.5
Russell, D.6
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39
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35048831934
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Effect of CCR5 antagonist UK-427,857 on the pharmacokinetics of CYP3A4 substrates in healthy volunteers
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Presented at: April 1-3, Rome, Italy. Poster 5.7
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Abel S, Russell D, Ridgway C, Medhurst C, Whitlock L, Weissgerber G, Muirhead G. Effect of CCR5 antagonist UK-427,857 on the pharmacokinetics of CYP3A4 substrates in healthy volunteers. Presented at: 5th International Workshop on Clinical Pharmacology of HIV Therapy; April 1-3, 2004; Rome, Italy. Poster 5.7.
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(2004)
5th International Workshop on Clinical Pharmacology of HIV Therapy
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Abel, S.1
Russell, D.2
Ridgway, C.3
Medhurst, C.4
Whitlock, L.5
Weissgerber, G.6
Muirhead, G.7
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