Is it all about sex? Acupuncture for the treatment of pain from a biological and gender perspective

Acupuncture in Medicine

Volumn 26, Issue 1, 2008, Pages 33-45

  Lund, Iréne ^a   Lundeberg, Thomas ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Sabbatsberg Hospital   (Sweden)

Author keywords

Acupuncture; Gender; Oestrogens; Pain; Sex differences; Testosterone

Indexed keywords

ADRENERGIC RECEPTOR; ANDROGEN; ANDROGEN RECEPTOR; ANDROSTANOLONE; AROMATASE; CALCITONIN GENE RELATED PEPTIDE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SEX HORMONE BINDING GLOBULIN; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ACUPUNCTURE; CHROMOSOME; CYSTALGIA; DNA BINDING; DYSMENORRHEA; FIBROMYALGIA; GENE; GENETIC DIFFERENCE; GONAD; HUMAN; IRRITABLE COLON; MELANOCORTIN 1 RECEPTOR GENE; MIGRAINE; PAIN; PAIN ASSESSMENT; PELVIS PAIN SYNDROME; PSYCHOLOGICAL ASPECT; REVIEW; RHEUMATOID ARTHRITIS; SENSORY STIMULATION; SEX DIFFERENCE; TEMPOROMANDIBULAR JOINT DISORDER;

EID: 41649104474     PISSN: 09645284     EISSN: None     Source Type: Journal    
DOI: 10.1136/aim.26.1.33     Document Type: Review

References (143)

1. Collett BJ, Berkley K. Task force on fact sheets for the global year against pain 'Pain in Women' 2007/28. The IASP Global Year against pain in women. Pain 2007;132(Suppl1):S1-2.
2. Holdcroft AI, Berkley KJ. Sex and gender differences in pain. In: Wall and Melzack's Textbook of Pain (5th ed.), edited by McMahon SB and Koltzenberg M. Edinburgh, UK: Elsevier, 2005, p. 1181-1197.
3. Bingefors K, Isacson D. Epidemiology, co-morbidity, and impact on health-related quality of life of self-reported headache and musculoskeletal pain - a gender perspective. Eur J Pain 2004;8(5):435-50.
4. Isacson D, Bingefors K. Epidemiology of analgesic use: a gender perspective. Eur J Anaesthesiol Suppl 2002;26:5-15.
5. Fillingim RB. Sex, Gender and Pain. Progress in pain research and management, vol 17. IASP press 2000.
6. Mogil JS, Chanda ML. The case for the inclusion of female subjects in basic science studies of pain. Pain 2005;117(1-2):1-5.
7. Chen W, Woods SL, Puntillo KA. Gender differences in symptoms associated with acute myocardial infarction: a review of the research. Heart Lung 2005;34(4):240-7.
8. Miaskowski C. Gender differences in pain, fatigue, and depression in patients with cancer. J Natl Cancer Inst Monogr 2004;(32):139-43.
9. Ettinger SM. Myocardial infarction and unstable angina: gender differences in therapy and outcomes. Curr Womens Health Rep 2003;3(2):140-8.
10. Levine JD, Khasar SG, Green PG. Neurogenic inflammation and arthritis. Ann N Y Acad Sci 2006;1069:155-67.
11. Fillingim RB, Maixner W, Kincaid S, Silva S. Sex differences in temporal summation but not sensory-discriminative processing of thermal pain. Pain 1998;75(1):121-7.
12. Rhudy JL, Williams AE. Gender differences in pain: do emotions play a role? Gend Med 2005;2(4):208-26.
13. Robinson ME, Gagnon CM, Riley JL, Price DD. Altering gender role expectations: effects on pain tolerance, pain threshold, and pain ratings. J Pain 2003;4(5):284-8.
14. Pool GJ, Schwegler AF, Theodore BR, Fuchs PN. Role of gender norms and group identification on hypothetical and experimental pain tolerance. Pain 2007;129(1-2):122-9.
15. Levine FM, De Simone LL. The effects of experimenter gender on pain report in male and female subjects. Pain 1991;44(1):69-72.
16. Gijsbers K, Nicholson F. Experimental pain thresholds influenced by sex of experimenter. Percept Mot Skills 2005;101(3):803-7.
17. Aloisi AM. Gonadal hormones and sex differences in pain reactivity. Clin J Pain 2003;19(3):168-74.
18. Heitkemper M, Jarrett M, Bond EF, Chang L. Impact of sex and gender on irritable bowel syndrome. Biol Res Nurs 2003;5(1):56-65.
19. Chang L, Heitkemper MM. Gender differences in irritable bowel syndrome. Gastroenterology 2002;123(5):1686-701.
20. Dina OA, Aley KO, Isenberg W, Messing RO, Levine JD. Sex hormones regulate the contribution of PKCepsilon and PKA signalling in inflammatory pain in the rat. Eur J Neurosci 2001;13(12):2227-33.
21. Berkley KJ. Sex differences in pain. Behav Brain Sci 1997;20(3):371-80.
22. Coyle DE, Sehlhorst CS, Behbehani MM. Intact female rats are more susceptible to the development of tactile allodynia than ovariectomized female rats following partial sciatic nerve ligation (PSNL). Neurosci Lett 1996;203(1):37-40.
23. Gear RW, Gordon NC, Heller PH, Paul S, Miaskowski C, Levine JD. Gender difference in analgesic response to the kappa-opioid pentazocine. Neurosci Lett 1996;205(3):207-9.
24. Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, et al. Strategies and methods for research on sex differences in brain and behavior. Endocrinology 2005;146(4):1650-73.
25. Cahill L. Why sex matters for neuroscience. Nat Rev Neurosci 2006;7(6):477-84.
26. Zimmer C, Basler HD, Vedder H, Lautenbacher S. Sex differences in cortisol response to noxious stress. Clin J Pain 2003;19(4):233-9.
27. al'Absi M, Petersen KL, Wittmers LE. Adrenocortical and hemodynamic predictors of pain perception in men and women. Pain 2002;96(1-2):197- 204.
28. Canli T, Desmond JE, Zhao Z, Gabrieli JD. Sex differences in the neural basis of emotional memories. Proc Natl Acad Sci U S A 2002;99(16):10789-94.
29. Hinojosa-Laborde C, Chapa I, Lange D, Haywood JR. Gender differences in sympathetic nervous system regulation. Clin Exp Pharmacol Physiol 1999;26(2):122-6.
30. Girdler SS, Light KC. Hemodynamic stress responses in men and women examined as a function of female menstrual cycle phase. Int J Psychophysiol 1994;17(3):233-48.
31. Robinson ME, Wise EA, Gagnon C, Fillingim RB, Price DD. Influences of gender role and anxiety on sex differences in temporal summation of pain. J Pain 2004;5(2):77-82.
32. Sarlani E, Grace EG, Reynolds MA, Greenspan JD. Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation. Pain 2004;109(1-2):115-23.
33. Joseph EK, Parada CA, Levine JD. Hyperalgesic priming in the rat demonstrates marked sexual dimorphism. Pain 2003;105(1-2):143-50
34. Aloisi AM, Della Seta D, Rendo C, Ceccarelli I, Scaramuzzino A, Farabollini F. Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats. Brain Res 2002;937(1-2):1-7.
35. Naliboff BD, Berman S, Chang L, Derbyshire SW, Suyenobu B, Vogt BA, Mandelkern M, Mayer EA. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 2003;124(7):1738-47.
36. Ouyang A, Wrzos HF. Contribution of gender to pathophysiology and clinical presentation of IBS: should management be different in women? Am J Gastroenterol 2006;101(12 Suppl):S602-9.
37. Craft RM, Mogil JS, Aloisi AM. Sex differences in pain and analgesia: the role of gonadal hormones. Eur J Pain 2004;8(5):397-411.
38. Bennett HL, Gustafsson JA, Keast JR. Estrogen receptor expression in lumbosacral dorsal root ganglion cells innervating the female rat urinary bladder. Auton Neurosci 2003;105(2):90-100.
39. McEwen B. Estrogen actions throughout the brain. Recent Prog Horm Res 2002;57:357-84.
40. Papka RE, Storey-Workley M. Estrogen receptor-alpha and -beta coexist in a subpopulation of sensory neurons of female rat dorsal root ganglia. Neurosci Lett 2002;319(2):71-4.
41. Cui S, Goldstein RS. Expression of estrogen receptors in the dorsal root ganglia of the chick embryo. Brain Res 2000;882(1-2):236-40.
42. Woolley CS. Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus. Horm Behav 1998;34(2):140-8.
43. Ji Y, Tang B, Traub RJ. Modulatory effects of estrogen and progesterone on colorectal hyperalgesia in the rat. Pain 2005;117(3):433-42.
44. LaCroix-Fralish ML, Rutkowski MD, Weinstein JN, Mogil JS, Deleo JA. The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex. Spine 2005;30(16):1821-7.
45. Nemmani KV, Grisel JE, Stowe JR, Smith-Carliss R, Mogil JS. Modulation of morphine analgesia by site-specific N-methyl-Daspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain 2004;109(3):274-83.
46. Hucho TB, Dina OA, Kuhn J, Levine JD. Estrogen controls PKCepsilon-dependent mechanical hyperalgesia through direct action on nociceptive neurons. Eur J Neurosci 2006;24(2):527-34.
47. Falkenstein E, Tillmann HC, Christ M, Feuring M, Wehling M. Multiple actions of steroid hormones - a focus on rapid, nongenomic effects. Pharmacol Rev 2000;52(4):513-56.
48. Evrard HC, Willems E, Harada N, Balthazart J. Specific innervation of aromatase neurons by substance P fibers in the dorsal horn of the spinal cord in quail. J Comp Neurol 2003;465(2):309-18.
49. Cyr M, Ghribi O, Thibault C, Morissette M, Landry M, Di Paolo T. Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors. Brain Res Rev 2001;37(1-3):153-61.
50. Marvizon JC, McRoberts JA, Ennes HS, Song B, Wang X, Jinton L, et al. Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization. J Comp Neurol 2002;446(4):325-41.
51. Cairns BE, Svensson P, Wang K, Castrillon E, Hupfeld S, Sessle BJ, Arendt-Nielsen L. Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Exp Brain Res 2006;169(4):467-72.
52. Cairns BE, Svensson P, Wang K, Hupfeld S, Graven-Nielsen T, Sessle BJ, et al. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol 2003;90(4):2098-105.
53. Du J, Zhou S, Coggeshall RE, Carlton SM. N-methyl-D-aspartate-induced excitation and sensitization of normal and inflamed nociceptors. Neuroscience 2003;118(2):547-62.
54. Zhou S, Bonasera L, Carlton SM. Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats. Neuroreport 1996;7(4):895-900.
55. Hucho TB, Dina OA, Levine JD. Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism. J Neurosci 2005;25(26):6119-26.
56. Khasar SG, McCarter G, Levine JD, Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 1999;81(3):1104-12.
57. McRoberts JA, Coutinho SV, Marvizon JC, Grady EF, Tognetto M, Sengupta JN, et al. Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology 2001;120(7):1737-48.
58. Olivar T, Laird JM. Differential effects of N-methyl-D-aspartate receptor blockade on nociceptive somatic and visceral reflexes. Pain 1999;79(1):67-73.
59. Manni L, Lundeberg T, Fiorito S, Bonini S, Vigneti E, Aloe L. Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor necrosis factor-alpha, interleukin-1 beta and cholecystokinin-8: the possible role of NGF in the inflammatory response. Clin Exp Rheumatol 2003;21(5):617-24.
60. Jansen GB, Torkvist L, Lofgren O, Raud J, Lundeberg T. Effects of calcitonin gene-related peptide on tissue survival, blood flow and neutrophil recruitment in experimental skin flaps. Br J Plast Surg 1999;52(4):299-303.
61. Bileviciute I, Lundeberg T, Ekblom A, Theodorsson E. Substance P-, neurokinin A-, calcitonin gene-related peptide-and neuropeptide Y-like immunoreactivity (-LI) in rat knee joint synovial fluid during acute monoarthritis is not correlated with concentrations of neuropeptide-LI in cerebrospinal fluid and plasma. Neurosci Lett 1994;167(1-2):145-8.
62. Lundeberg T. Peripheral effects of sensory nerve stimulation (acupuncture) in inflammation and ischemia. Scand J Rehabil Med Suppl 1993;29:61-86.
63. Raud J, Lundeberg T, Brodda-Jansen G, Theodorsson E, Hedqvist P. Potent anti-inflammatory action of calcitonin gene-related peptide. Biochem Biophys Res Commun 1991;180(3):1429-35.
64. Larsson J, Ekblom A, Henriksson K, Lundeberg T, Theodorsson E. Immunoreactive tachykinins, calcitonin gene-related peptide and neuropeptide Y in human synovial fluid from inflamed knee joints. Neurosci Lett 1989;100(1-3):326-30.
65. Mogil JS, Miermeister F, Seifert F, Strasburg K, Zimmermann K, Reinold H, et al. Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. Proc Natl Acad Sci U S A 2005;102(36):12938-43.
66. Malcangio M, Fernandes K, Tomlinson DR. NMDA receptor activation modulates evoked release of substance P from rat spinal cord. Br J Pharmacol 1998;125(8):1625-6.
67. Liu H, Mantyh PW, Basbaum AI. NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature 1997;386(6626):721-4.
68. Marvizon JC, Martinez V, Grady EF, Bunnett NW, Mayer EA. Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors. J Neurosci 1997;17(21):8129-36.
69. Herrero JF, Laird JM, Lopez-Garcia JA. Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol 2000;61(2):169-203.
70. Berman S, Munakata J, Naliboff BD, Chang L, Mandelkern M, Silverman D, et al. Gender differences in regional brain response to visceral pressure in IBS patients. Eur J Pain 2000;4(2):157-72.
71. Staud R, Robinson ME, Vierck CJ Jr, Price DD. Diffuse noxious inhibitory controls (DNIC) attenuate temporal summation of second pain in normal males but not in normal females or fibromyalgia patients. Pain 2003;101(1-2):167- 74.
72. McRoberts JA, Li J, Ennes HS, Mayer EA. Sex-dependent differences in the activity and modulation of N-methyl-d-aspartic acid receptors in rat dorsal root ganglia neurons. Neuroscience 2007;148(4):1015-20.
73. Li J, McRoberts JA, Ennes HS, Trevisani M, Nicoletti P, Mittal Y, et al. Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons. Am J Physiol Gastrointest Liver Physiol 2006;291(12):G219-28.
74. Levin ER. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005;19(8):1951-9.
75. Zivadinovic D, Gametchu B, Watson CS. Membrane estrogen receptor-alpha levels in MCF-7 breast cancer cells predict cAMP and proliferation responses. Breast Cancer Res 2005;7(1):R101-12.
76. Björnström L, Sjöberg M. Estrogen receptor-dependent activation of AP-1 via non-genomic signalling. Nucl Recept 2004;2(1):3.
77. Bi R, Broutman G, Foy MR, Thompson RF, Baudry M. The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus. Proc Natl Acad Sci U S A 2000;97(7):3602-7.
78. Woolley CS, Weiland NG, McEwen BS, Schwartzkroin PA. Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density. J Neurosci 1997;17(5):1848-59.
79. Gazzaley AH, Weiland NG, McEwen BS, Morrison JH. Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus. J Neurosci 1996;16(21):6830-38.
80. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H, et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995;270(5241):1491-4.
81. Vyklicky L, Knotkova-Urbancova H Can sensory neurones in culture serve as a model of nociception? Physiol Res 1996;45(1):1-9.
82. Cairns BE, Wang K, Hu JW, Sessle BJ, Arendt-Nielsen L, Svensson P. The effect of glutamate-evoked masseter muscle pain on the human jaw-stretch reflex differs in men and women. J Orofac Pain 2003;17(4):317-25.
83. Svensson P, Cairns BE, Wang K, Hu JW, Graven-Nielsen T, Arendt-Nielsen L, et al. Glutamate-evoked pain and mechanical allodynia in the human masseter muscle. Pain 2003;101(3):221-7.
84. Carlton SM, Hargett GL, Coggeshall RE. Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. Neurosci Lett 1995;197(1):25-8.
85. Aloisi AM, Bachiocco V, Costantino A, Stefani R, Ceccarelli I, Bertaccini A, et al. Cross-sex hormone administration changes pain in transsexual women and men. Pain 2007;132(Suppl 1):S60-7.
86. Cairns BE. The influence of gender and sex steroids on craniofacial nociception. Headache 2007;47(2):319-24.
87. Craft RM, Ulibarri C, Leitl MD, Sumner JE. Dose- and time-dependent estradiol modulation of morphine antinociception in adult female rats. Eur J Pain 2007;Sep12; [Epub ahead of print].
88. Kuba T, Quinones-Jenab V. The role of female gonadal hormones in behavioral sex differences in persistent and chronic pain: clinical versus preclinical studies. Brain Res Bull 2005;66(3):179-88.
89. Nag S, Mokha SS. Activation of alpha2-adrenoceptors in the trigeminal region produces sex-specific modulation of nociception in the rat. Neuroscience 2006;142(4):1255-62.
90. Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KV, Lariviere WR, et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A 2003;100(8):4867-72.
91. Han JS. Acupuncture and endorphins. Neurosci Lett 2004;361(1-3):258-61.
92. Le Bars D. The whole body receptive field of dorsal horn multireceptive neurones. Brain Res Brain Res Rev 2002;40(1-3):29-44.
93. Rainville P. Brain mechanisms of pain affect and pain modulation. Curr Opin Neurobiol 2002;12(2):195-204.
94. Basbaum AI, Fields HL. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 1984;7:309-38.
95. Bodnar RJ, Klein GE. Endogenous opiates and behavior: 2004. Peptides 2005;26(12):2629-711.
96. Millan MJ. Descending control of pain. Prog Neurobiol 2002;66(6):355-474.
97. Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Jewett DM, et al. mu-opioid receptor-mediated antinociceptive responses differ in men and women. J Neurosci 2002;22(12):5100-7.
98. Fillingim RB, Gear RW. Sex differences in opioid analgesia: clinical and experimental findings. Eur J Pain 2004;8(5):413-25.
99. Tershner SA, Mitchell JM, Fields HL. Brainstem pain modulating circuitry is sexually dimorphic with respect to mu and kappa opioid receptor function. Pain 2000;85(1-2):153-9.
100. Bernal SA, Morgan MM, Craft RM. PAG mu opioid receptor activation underlies sex differences in morphine antinociception. Behav Brain Res 2007;177(1):126-33.
101. Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, Levine JD. The kappa opioid nalbuphine produces gender-and dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain 1999;83(2):339-45.
102. Andersson S, Lundeberg T. Acupuncture-from empiricism to science: functional background to acupuncture effects in pain and disease. Med Hypotheses 1995;45(3):271-81.
103. Liu LJ, Du HL, Jin YC, Chen JW. [Effects of combined acupuncture and medicine therapy on the breast tissue and expressions of estrogen receptor subgroups in the rat of hyperplasia of mammary glands.] Zhongguo Zhen Jiu 2007;27(4):279-83.
104. Yao X, Wang XQ, Ma SL, Chen BY. Electroacupuncture stimulates the expression of prolactin-releasing peptide (PrRP) in the medulla oblongata of ovariectomized rats. Neurosci Lett 2007;411(3):243-8.
105. Zhao H, Tian Z, Feng Y, Chen B. Circulating estradiol and hypothalamic corticotrophin releasing hormone enhances along with time after ovariectomy in rats: effects of electroacupuncture. Neuropeptides 2005;39(4):433-8.
106. Dahlin L, Lund I, Lundeberg T, Molander C. Vibratory stimulation increase the electro-cutaneous sensory detection and pain thresholds in women but not in men. BMC Complement Altern Med 2006;6:20.
107. Lund I, Lundeberg T, Kowalski J, Svensson E. Gender differences in electrical pain threshold responses to transcutaneous electrical nerve stimulation (TENS) Neurosci Lett 2005;375(2):75-80.
108. Näslund J, Näslund UB, Odenbring S, Lundeberg T. Sensory stimulation (acupuncture) for the treatment of idiopathic anterior knee pain. J Rehabil Med 2002;34(5):231-8.
109. Tzafettas J. Painful menstruation. Pediatr Endocrinol Rev 2006;3 Suppl 1:160-3.
110. Habek D, Cerkez Habek J, Bobić-Vuković M, Vujić B. Efficacy of Acupuncture for the treatment of primary dysmenorrhea. Gynakol Geburtshilfliche Rundsch 2003;43(4):250-3.
111. White AR. A review of controlled trials of acupuncture for women's reproductive health care. J Fam Plann Reprod Health Care 2003;29(4):233-6.
112. Zhi LX. Randomized controlled study on superficial needling for treatment of primary dysmenorrhea. Zhongguo Zhen Jiu 2007;27(1):18-21.
113. Gong P, Zhang MM, Wang Q, Wu ZJ, Huang XT, Wang W, et al. [Effect of acupuncture at Sanyinjiao (SP6) on glucose metabolism in the patient of dysmenorrhea.] Zhongguo Zhen Jiu 2006;26(1):51-5.
114. Pouresmail Z, Ibrahimzadeh R. Effects of acupressure and ibuprofen on the severity of primary dysmenorrhea. J Tradit Chin Med 2002;22(3):205-10.
115. Jun EM, Chang S, Kang DH, Kim S. Effects of acupressure on dysmenorrhea and skin temperature changes in college students: a non-randomized controlled trial. Int J Nurs Stud 2007;44(6):973-81.
116. Chen HM, Chen CH. Effects of acupressure at the Sanyinjiao point on primary dysmenorrhoea. J Adv Nurs 2004;48(4):380-7.
117. Pennick VE, Young G. Interventions for preventing and treating pelvic and back pain in pregnancy. Cochrane Database Syst Rev 2007;(2):CD001139.
118. Lund I, Lundeberg T, Lönnberg L, Svensson E. Decrease of pregnant women's pelvic pain after acupuncture: a randomized controlled single-blind study. Acta Obstet Gynecol Scand 2006;85(1):12-9.
119. Elden H, Ladfors L, Olsen MF, Ostgaard HC, Hagberg H. Effects of acupuncture and stabilising exercises as adjunct to standard treatment in pregnant women with pelvic girdle pain: randomised single blind controlled trial. BMJ 2005;330(7494):761-6.
120. Kvorning N, Holmberg C, Grennert L, Aberg A, Akeson J. Acupuncture relieves pelvic and low-back pain in late pregnancy. Acta Obstet Gynecol Scand 2004;83(3):246-50.
121. Wedenberg K, Moen B, Norling A. A prospective randomized study comparing acupuncture with physiotherapy for low-back and pelvic pain in pregnancy. Acta Obstet Gynecol Scand 2000;79(5):331-5.
122. Highfield ES, Laufer MR, Schnyer RN, Kerr CE, Thomas P, Wayne PM. Adolescent endometriosis-related pelvic pain treated with acupuncture: two case reports. J Altern Complement Med 2006;12(3):317-22.
123. Sun YZ, Chen HL. [Controlled study on Shu-Mu point combination for treatment of endometriosis.] Zhongguo Zhen Jiu 2006;26(12):863-5.
124. Xiang D, Situ Y, Liang X, Cheng L, Zhang G. Ear acupuncture therapy for 37 cases of dysmenorrhea due to endometriosis. J Tradit Chin Med 2002;22(4):282-5.
125. Butrick CW. Patients with chronic pelvic pain: endometriosis or interstitial cystitis/painful bladder syndrome? JSLS 2007;11(2):182-9.
126. Alraek T, Baerheim A. The effect of prophylactic acupuncture treatment in women with recurrent cystitis: kidney patients fare better. J Altern Complement Med 2003;9(5):651-8.
127. Rohrböck RB, Hammer J, Vogelsang H, Talley NJ, Hammer HF. Acupuncture has a placebo effect on rectal perception but not on distensibility and spatial summation: a study in health and IBS. Am J Gastroenterol 2004;99(10):1990-7.
128. Xiao WB, Liu YL. Rectal hypersensitivity reduced by acupoint TENS in patients with diarrhea-predominant irritable bowel syndrome: a pilot study. Dig Dis Sci 2004;49(2):312-9.
129. Xing J, Larive B, Mekhail N, Soffer E. Transcutaneous electrical acustimulation can reduce visceral perception in patients with the irritable bowel syndrome: a pilot study. Altern Ther Health Med 2004;10(1):38-42.
130. Iwa M, Strickland C, Nakade Y, Pappas TN, Takahashi T. Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs. Dig Dis Sci 2005;50(7):1264-70.
131. Schneider A, Enck P, Streitberger K, Weiland C, Bagheri S, Witte S, et al. Acupuncture treatment in irritable bowel syndrome. Gut 2006;55(5):649-54.
132. Forbes A, Jackson S, Walter C, Quraishi S, Jacyna M, Pitcher M. Acupuncture for irritable bowel syndrome: a blinded placebo-controlled trial. World J Gastroenterol 2005;11(26):4040-4.
133. Lundeberg T, Lund I. Did 'The Princess on the Pea' suffer from fibromyalgia syndrome? The influence on sleep and the effects of acupuncture. Acupunct Med 2007;25(4):184-97.
134. Lundeberg T, Lund I. Are reviews based on sham acupuncture procedures in fibromyalgia syndrome (FMS) valid? Acupunct Med 2007;25(3):100-6.
135. Lundeberg T, Lund I, Näslund J. Acupuncture - self-appraisal and the reward system. Acupunct Med 2007;25(3):87-99.
136. Lund I, Lundeberg T. Aspects of pain, its assessment and evaluation from an acupuncture perspective. Acupunct Med 2006;24(3):109-17.
137. Lund I, Lundeberg T. Are minimal, superficial or sham acupuncture procedures acceptable as inert placebo controls? Acupunct Med 2006;24(1):13-5.
138. Stener-Victorin E, Humaidan P. Use of acupuncture in female infertility and a summary of recent acupuncture studies related to embryo transfer. Acupunct Med 2006;24(4):157-163.
139. Humaidan P, Brock K, Bungum L, Stener-Victorin E. Pain relief during oocyte retrieval - exploring the role of different frequencies of electro-acupuncture. Reprod Biomed Online 2006;13(1):120-5.
140. Gejervall AL, Stener-Victorin E, Moller A, Janson PO, Werner C, Bergh C. Electro-acupuncture versus conventional analgesia: a comparison of pain levels during oocyte aspiration and patients' experiences of well-being after surgery. Hum Reprod 2005;20(3):728-35.
141. Humaidan P, Stener-Victorin E. Pain relief during oocyte retrieval with a new short duration electro-acupuncture technique - an alternative to conventional analgesic methods. Hum Reprod 2004;19(6):1367-72.
142. Stener-Victorin E, Waldenstrom U, Wikland M, Nilsson L, Hagglund L, Lundeberg T. Electro-acupuncture as a peroperative analgesic memod and its effects on implantation rate and neuropeptide Y concentrations in follicular fluid. Hum Reprod 2003;18(7):1454-60.
143. Stener-Victorin E, Waldenstrom U, Nilsson L, Wikland M, Janson PO. A prospective randomized study of electroacupuncture versus alfentanil as anaesthesia during oocyte aspiration in in-vitro fertilization. Hum Reprod 1999;14(10):2480-4.