Indoleamine 2,3-dioxygenase-dependent tryptophan metabolites contribute to tolerance induction during allergen immunotherapy in a mouse model

Journal of Allergy and Clinical Immunology

Volumn 121, Issue 4, 2008, Pages

  Taher, Yousef A ^a,c   Piavaux, Benoit J A ^c   Gras, Reneé ^c   van Esch, Betty C A M ^a   Hofman, Gerard A ^a   Bloksma, Nanne ^a,b   Henricks, Paul A J ^a   van Oosterhout, Antoon J M ^c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Allergic asthma; dendritic cell; eosinophilia; hyperresponsiveness; IgE; IL 10; immunotherapy; indoleamine 2,3 dioxygenase; kynurenine; regulatory T cells; suppression; TH2 lymphocytes; tryptophan

Indexed keywords

1 METHYL TRYPTOPHAN; 3 HYDROXYANTHRANILINIC ACID; 3 HYDROXYKYNURENINE; IMMUNOGLOBULIN E; INDOLEAMINE 2,3 DIOXYGENASE; KYNURENIC ACID; KYNURENINE; METHACHOLINE; OVALBUMIN; QUINOLINIC ACID; TRYPTOPHAN; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; XANTHURENIC ACID;

ALLERGIC ASTHMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; EOSINOPHIL; EOSINOPHILIA; IMMUNOTHERAPY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; TH2 CELL; TRYPTOPHAN METABOLISM;

EID: 41449087795     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.11.021     Document Type: Article

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