Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia

Life Sciences

Volumn 75, Issue 16, 2004, Pages 1967-1978

  Hatip Al Khatib, Izzettin ^a,b,c   Iwasaki, Katsunori ^b   Chung, Eun Hee ^b   Egashira, Nobuaki ^b   Mishima, Kenichi ^b   Fujiwara, Michihiro ^b  

^a Department of Pharmacology

^b FUKUOKA UNIVERSITY   (Japan)

^c PAMUKKALE UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Caspase 1; Caspase 3; PARP; Repeated cerebral ischemia reperfusion; Spatial memory

Indexed keywords

3 AMINOBENZAMIDE; CASPASE 3; CASPASE 3 INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL OCCLUSION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE TEST; MEMORY DISORDER; NONHUMAN; RAT; SPATIAL MEMORY;

ANIMALS; APOPTOSIS; BENZAMIDES; BRAIN ISCHEMIA; CASPASE 1; CASPASE 3; CASPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; IN SITU NICK-END LABELING; MALE; MEMORY DISORDERS; OLIGOPEPTIDES; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR;

EID: 4143149704     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.05.014     Document Type: Article

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