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Volumn 287, Issue 3 56-3, 2004, Pages

Chronic in ovo hypoxia decreases pulmonary arterial contractile reactivity and induces biventricular cardiac enlargement in the chicken embryo

Author keywords

Cardiac hypertrophy; Endothelium; Pulmonary hypertension

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ENDOTHELIN 1; ENDOTHELIUM DERIVED RELAXING FACTOR; NORADRENALIN; POTASSIUM CHLORIDE; THROMBOXANE A2;

EID: 4143129729     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00611.2003     Document Type: Article
Times cited : (67)

References (64)
  • 1
    • 0002392691 scopus 로고    scopus 로고
    • Perinatal pulmonary vasoregulation: Implications for the pathophysiology and treatment of neonatal pulmonary hypertension
    • edited by Haddad G and Lister G. New York: Dekker
    • Abman SH and Stevens T. Perinatal pulmonary vasoregulation: implications for the pathophysiology and treatment of neonatal pulmonary hypertension. In: Tissue Oxygen Deprivation: Developmental, Molecular and Integrative Function, edited by Haddad G and Lister G. New York: Dekker, 1996, p. 367-432.
    • (1996) Tissue Oxygen Deprivation: Developmental, Molecular and Integrative Function , pp. 367-432
    • Abman, S.H.1    Stevens, T.2
  • 3
    • 0025963441 scopus 로고
    • Loss of endothelium dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia
    • Adnot S, Raffestin B, Eddahihi S, Braquet P, and Chabrier PE. Loss of endothelium dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J Clin Invest 87: 155-162, 1991.
    • (1991) J Clin Invest , vol.87 , pp. 155-162
    • Adnot, S.1    Raffestin, B.2    Eddahihi, S.3    Braquet, P.4    Chabrier, P.E.5
  • 5
    • 0014977005 scopus 로고
    • The adrenergic innervation of the pulmonary vasculature, the lung and the thoracic aorta, and on the presence of aortic bodies in the domestic fowl (Gallus gallus domesticus L.)
    • Bennet T. The adrenergic innervation of the pulmonary vasculature, the lung and the thoracic aorta, and on the presence of aortic bodies in the domestic fowl (Gallus gallus domesticus L.). Z Zellforsch Mikrosk Anat 114: 117-134, 1971.
    • (1971) Z Zellforsch Mikrosk Anat , vol.114 , pp. 117-134
    • Bennet, T.1
  • 7
    • 0017760003 scopus 로고
    • Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery
    • Casteels R, Kitamura K, Kuriyama H, and Suzuki H. Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery. J Physiol 271: 63-79, 1977.
    • (1977) J Physiol , vol.271 , pp. 63-79
    • Casteels, R.1    Kitamura, K.2    Kuriyama, H.3    Suzuki, H.4
  • 8
    • 0035986049 scopus 로고    scopus 로고
    • Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat
    • Chicoine LG, Avitia JW, Deen C, Nelin LD, Earley S, and Walker BR. Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat. J Appl Physiol 93: 311-318, 2002.
    • (2002) J Appl Physiol , vol.93 , pp. 311-318
    • Chicoine, L.G.1    Avitia, J.W.2    Deen, C.3    Nelin, L.D.4    Earley, S.5    Walker, B.R.6
  • 10
    • 0017851438 scopus 로고
    • Persistent pulmonary hypertension in the neonate: Development of an animal model
    • Drummond WH and Bissonnette JM. Persistent pulmonary hypertension in the neonate: development of an animal model. Am J Obstet Gynecol 131: 761-763, 1978.
    • (1978) Am J Obstet Gynecol , vol.131 , pp. 761-763
    • Drummond, W.H.1    Bissonnette, J.M.2
  • 11
    • 0022479969 scopus 로고
    • Effects of chronic in utero hypoxemia on rat neonatal pulmonary arterial structure
    • Geggel RL, Aronovitz MJ, and Reid LM. Effects of chronic in utero hypoxemia on rat neonatal pulmonary arterial structure. J Pediatr 108: 756-759, 1986.
    • (1986) J Pediatr , vol.108 , pp. 756-759
    • Geggel, R.L.1    Aronovitz, M.J.2    Reid, L.M.3
  • 13
    • 0027474258 scopus 로고
    • Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep
    • Giussani DA, Spencer JAD, Moore PJ, Bennet L, and Hanson MA. Afferent and efferent components of the cardiovascular reflex responses to acute hypoxia in term fetal sheep. J Physiol 461: 431-449, 1993.
    • (1993) J Physiol , vol.461 , pp. 431-449
    • Giussani, D.A.1    Spencer, J.A.D.2    Moore, P.J.3    Bennet, L.4    Hanson, M.A.5
  • 14
    • 0015136213 scopus 로고
    • The effects of maternal hypoxia and hyperoxia upon the neonatal pulmonary vasculature
    • Goldberg SJ, Levy RA, Siassi B, and Betten J. The effects of maternal hypoxia and hyperoxia upon the neonatal pulmonary vasculature. Pediatrics 48: 528-533, 1971.
    • (1971) Pediatrics , vol.48 , pp. 528-533
    • Goldberg, S.J.1    Levy, R.A.2    Siassi, B.3    Betten, J.4
  • 15
    • 0034078182 scopus 로고    scopus 로고
    • Neonatal pulmonary hypertension prevents reorganisation of the pulmonary arterial smooth muscle cytoskeleton after birth
    • Hall SM, Gorenflo M, Reader J, Lawson D, and Haworth SG. Neonatal pulmonary hypertension prevents reorganisation of the pulmonary arterial smooth muscle cytoskeleton after birth. J Anat 196: 391-403, 2000.
    • (2000) J Anat , vol.196 , pp. 391-403
    • Hall, S.M.1    Gorenflo, M.2    Reader, J.3    Lawson, D.4    Haworth, S.G.5
  • 16
    • 0027018236 scopus 로고
    • A series of normal stages in the development of the chick embryo
    • Hamburger V and Hamilton HL. A series of normal stages in the development of the chick embryo. 1951. Dev Dyn 195: 231-272, 1992.
    • (1951) Dev Dyn , vol.195 , pp. 231-272
    • Hamburger, V.1    Hamilton, H.L.2
  • 17
    • 0025063574 scopus 로고
    • Perinatal hypoxia increases hypoxic pulmonary vasoconstriction in adult rats recovering from chronic exposure to hypoxia
    • Hampl V and Herget J. Perinatal hypoxia increases hypoxic pulmonary vasoconstriction in adult rats recovering from chronic exposure to hypoxia. Am Rev Respir Dis 142: 619-624, 1990.
    • (1990) Am Rev Respir Dis , vol.142 , pp. 619-624
    • Hampl, V.1    Herget, J.2
  • 18
    • 0033370832 scopus 로고    scopus 로고
    • Differential signaling pathways of HO-1 gene expression in pulmonary and systemic vascular cells
    • Hartsfield CL, Alam J, and Choi AM. Differential signaling pathways of HO-1 gene expression in pulmonary and systemic vascular cells. Am J Physiol Lung Cell Mol Physiol 277: L1133-L1141, 1999.
    • (1999) Am J Physiol Lung Cell Mol Physiol , vol.277
    • Hartsfield, C.L.1    Alam, J.2    Choi, A.M.3
  • 19
    • 0030857356 scopus 로고    scopus 로고
    • The pathophysiology of persistent pulmonary hypertension of the newborn
    • Haworth SG. The pathophysiology of persistent pulmonary hypertension of the newborn. Semin Neonatol 2: 13-23, 1997.
    • (1997) Semin Neonatol , vol.2 , pp. 13-23
    • Haworth, S.G.1
  • 20
    • 0037301134 scopus 로고    scopus 로고
    • Lung development-the effects of chronic hypoxia
    • Haworth SG and Hislop AA. Lung development-the effects of chronic hypoxia. Semin Neonatol 8: 1-8, 2003.
    • (2003) Semin Neonatol , vol.8 , pp. 1-8
    • Haworth, S.G.1    Hislop, A.A.2
  • 21
    • 0017283225 scopus 로고
    • Persistent fetal circulation: Newly recognized structural features
    • Haworth SG and Reid L. Persistent fetal circulation: newly recognized structural features. J Pediatr 88: 614-620, 1976.
    • (1976) J Pediatr , vol.88 , pp. 614-620
    • Haworth, S.G.1    Reid, L.2
  • 23
    • 0011788839 scopus 로고
    • The histogenesis of the arteries of the chick embryo
    • Hughes AFW. The histogenesis of the arteries of the chick embryo. J Anat 77: 266-287, 1943.
    • (1943) J Anat , vol.77 , pp. 266-287
    • Hughes, A.F.W.1
  • 24
    • 0034809282 scopus 로고    scopus 로고
    • Correlation of HO-1 expression with onset and reversal of hypoxia-induced vasoconstrictor hyporeactivity
    • Jernigan NL, O'Donaughy TL, and Walker BR. Correlation of HO- 1 expression with onset and reversal of hypoxia-induced vasoconstrictor hyporeactivity. Am J Physiol Heart Circ Physiol 281: H298-H307, 2001.
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Jernigan, N.L.1    O'Donaughy, T.L.2    Walker, B.R.3
  • 26
    • 19144364892 scopus 로고
    • The effects of chronic hypoxia on the pharmacological responsiveness of the pulmonary artery
    • Karamsetty VS, Kane KA, and Wadsworth RM. The effects of chronic hypoxia on the pharmacological responsiveness of the pulmonary artery. Pharmacol Ther 68: 233-246, 1995.
    • (1995) Pharmacol Ther , vol.68 , pp. 233-246
    • Karamsetty, V.S.1    Kane, K.A.2    Wadsworth, R.M.3
  • 27
    • 0033712091 scopus 로고    scopus 로고
    • Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats
    • Keith IM, Tjen-ALooi S, Kraiczi H, and Ekman R. Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol 279: H1571-H1578, 2000.
    • (2000) Am J Physiol Heart Circ Physiol , vol.279
    • Keith, I.M.1    Tjen-Alooi, S.2    Kraiczi, H.3    Ekman, R.4
  • 28
    • 0006009803 scopus 로고
    • The structure of the intrapulmonary vasculature of the domestic fowl
    • edited by Piiper J. New York: Springer-Verlag
    • King AS, King DZ, and Abdalla MA. The structure of the intrapulmonary vasculature of the domestic fowl. In: Respiratory Function in Birds Adult and Embryonic, edited by Piiper J. New York: Springer-Verlag, 1978, p. 112-124.
    • (1978) Respiratory Function in Birds Adult and Embryonic , pp. 112-124
    • King, A.S.1    King, D.Z.2    Abdalla, M.A.3
  • 29
    • 0030023029 scopus 로고    scopus 로고
    • Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung
    • Le Cras TD, Xue C, Rengasamy A, and Johns RA. Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol Lung Cell Mol Physiol 270: L164-L170, 1996.
    • (1996) Am J Physiol Lung Cell Mol Physiol , vol.270
    • Le Cras, T.D.1    Xue, C.2    Rengasamy, A.3    Johns, R.A.4
  • 30
    • 0038278529 scopus 로고    scopus 로고
    • Cardiac hypertrophy and altered hemodynamic adaptation in growth-restricted preterm infants
    • Leipala JA, Boldt T, Turpeinen U, Vuolteenaho O, and Fellman V. Cardiac hypertrophy and altered hemodynamic adaptation in growth-restricted preterm infants. Pediatr Res 53: 989-993, 2003.
    • (2003) Pediatr Res , vol.53 , pp. 989-993
    • Leipala, J.A.1    Boldt, T.2    Turpeinen, U.3    Vuolteenaho, O.4    Fellman, V.5
  • 34
    • 0031957221 scopus 로고    scopus 로고
    • Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1
    • Martin C, Yu AY, Jiang BH, Davis L, Kimberly D, Hohimer AR, and Semenza GL. Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1. Am J Obstet Gynecol 178: 527-534, 1998.
    • (1998) Am J Obstet Gynecol , vol.178 , pp. 527-534
    • Martin, C.1    Yu, A.Y.2    Jiang, B.H.3    Davis, L.4    Kimberly, D.5    Hohimer, A.R.6    Semenza, G.L.7
  • 36
    • 0036176715 scopus 로고    scopus 로고
    • Effects of chronic hypoxia and protein malnutrition on growth in the developing chick
    • Miller SL, Green LR, Peebles DM, Hanson MA, and Blanco CE. Effects of chronic hypoxia and protein malnutrition on growth in the developing chick. Am J Obstet Gynecol 186: 261-267, 2002.
    • (2002) Am J Obstet Gynecol , vol.186 , pp. 261-267
    • Miller, S.L.1    Green, L.R.2    Peebles, D.M.3    Hanson, M.A.4    Blanco, C.E.5
  • 39
    • 0022642155 scopus 로고
    • Effects of chronic in utero hypoxia on the pulmonary vasculature of the newborn guinea pig
    • Murphy JD, Aronovitz MJ, and Reid LM. Effects of chronic in utero hypoxia on the pulmonary vasculature of the newborn guinea pig. Pediatr Res 20: 292-295, 1986.
    • (1986) Pediatr Res , vol.20 , pp. 292-295
    • Murphy, J.D.1    Aronovitz, M.J.2    Reid, L.M.3
  • 40
    • 0021748799 scopus 로고
    • Myocardial cell hypertrophy or hyperplasia
    • Oparil S, Bishop SP, and Clubb FJ Jr. Myocardial cell hypertrophy or hyperplasia. Hypertension 6: 11138-11143, 1984.
    • (1984) Hypertension , vol.6 , pp. 11138-11143
    • Oparil, S.1    Bishop, S.P.2    Clubb Jr., F.J.3
  • 41
    • 0031807883 scopus 로고    scopus 로고
    • Myosin isoform shifts and decreased reactivity in hypoxia-induced hypertensive pulmonary arterial muscle
    • Packer CS, Roepke JE, Oberlies NH, and Rhoades RA. Myosin isoform shifts and decreased reactivity in hypoxia-induced hypertensive pulmonary arterial muscle. Am J Physiol Lung Cell Mol Physiol 274: L775-L785, 1998.
    • (1998) Am J Physiol Lung Cell Mol Physiol , vol.274
    • Packer, C.S.1    Roepke, J.E.2    Oberlies, N.H.3    Rhoades, R.A.4
  • 43
    • 0036784045 scopus 로고    scopus 로고
    • Oxygen-dependent signaling in pulmonary vascular smooth muscle
    • Raj U and Shimoda L. Oxygen-dependent signaling in pulmonary vascular smooth muscle. Am J Physiol Lung Cell Mol Physiol 283: L671-L677, 2002.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283
    • Raj, U.1    Shimoda, L.2
  • 44
    • 0032033845 scopus 로고    scopus 로고
    • Metabolic and circulatory adaptations to chronic hypoxia in the fetus
    • Richardson BS and Bocking AD. Metabolic and circulatory adaptations to chronic hypoxia in the fetus. Comp Biochem Physiol A 119: 717-723, 1998.
    • (1998) Comp Biochem Physiol A , vol.119 , pp. 717-723
    • Richardson, B.S.1    Bocking, A.D.2
  • 45
    • 0037062649 scopus 로고    scopus 로고
    • Hypoxia induces aortic hypertrophic growth, left ventricular dysfunction, and sympathetic hyperinnervation of peripheral arteries in the chick embryo
    • Rouwet EV, Tintu AN, Schellings MW, van Bilsen M, Lutgens E, Hofstra L, Slaaf DW, Ramsay G, and Le Noble FA. Hypoxia induces aortic hypertrophic growth, left ventricular dysfunction, and sympathetic hyperinnervation of peripheral arteries in the chick embryo. Circulation 105: 2791-2796, 2002.
    • (2002) Circulation , vol.105 , pp. 2791-2796
    • Rouwet, E.V.1    Tintu, A.N.2    Schellings, M.W.3    Van Bilsen, M.4    Lutgens, E.5    Hofstra, L.6    Slaaf, D.W.7    Ramsay, G.8    Le Noble, F.A.9
  • 46
    • 0036340106 scopus 로고    scopus 로고
    • The chicken embryo in developmental physiology of the cardiovascular system: A traditional model with new possibilities
    • Ruijtenbeek K, De Mey JG, and Blanco CE. The chicken embryo in developmental physiology of the cardiovascular system: a traditional model with new possibilities. Am J Physiol Regul Integr Comp Physiol 283: R549-R550, 2002.
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.283
    • Ruijtenbeek, K.1    De Mey, J.G.2    Blanco, C.E.3
  • 47
    • 0037385846 scopus 로고    scopus 로고
    • Chronic moderate hypoxia and protein malnutrition both induce growth retardation, but have distinct effects on arterial endothelium-dependent reactivity in the chicken embryo
    • Ruijtenbeek K, Kessels LC, De Mey JG, and Blanco CE. Chronic moderate hypoxia and protein malnutrition both induce growth retardation, but have distinct effects on arterial endothelium-dependent reactivity in the chicken embryo. Pediatr Res 53: 573-579, 2003.
    • (2003) Pediatr Res , vol.53 , pp. 573-579
    • Ruijtenbeek, K.1    Kessels, L.C.2    De Mey, J.G.3    Blanco, C.E.4
  • 50
    • 0032588806 scopus 로고    scopus 로고
    • α1-adrenergic hypothesis for pulmonary hypertension
    • Salvi SS. α1-Adrenergic hypothesis for pulmonary hypertension. Chest 115: 1708-1719, 1999.
    • (1999) Chest , vol.115 , pp. 1708-1719
    • Salvi, S.S.1
  • 51
    • 0033606527 scopus 로고    scopus 로고
    • Augmented vasoreactivity in adult life associated with perinatal vascular insult
    • Sartori C, Allemann Y, Trueb L, Delabays A, Nicod P, and Scherrer U. Augmented vasoreactivity in adult life associated with perinatal vascular insult. Lancet 353: 2205-2207, 1999.
    • (1999) Lancet , vol.353 , pp. 2205-2207
    • Sartori, C.1    Allemann, Y.2    Trueb, L.3    Delabays, A.4    Nicod, P.5    Scherrer, U.6
  • 53
    • 0027370627 scopus 로고
    • Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms
    • Shaul PW, Wells LB, and Horning KM. Acute and prolonged hypoxia attenuate endothelial nitric oxide production in rat pulmonary arteries by different mechanisms. J Cardiovasc Pharmacol 22: 819-827, 1993.
    • (1993) J Cardiovasc Pharmacol , vol.22 , pp. 819-827
    • Shaul, P.W.1    Wells, L.B.2    Horning, K.M.3
  • 54
    • 0028521030 scopus 로고
    • Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells
    • Shaul PW and Wells LB. Oxygen modulates nitric oxide production selectively in fetal pulmonary endothelial cells. Am J Respir Cell Mol Biol 11: 432-438, 1994.
    • (1994) Am J Respir Cell Mol Biol , vol.11 , pp. 432-438
    • Shaul, P.W.1    Wells, L.B.2
  • 55
    • 0014514946 scopus 로고
    • Development of the chick embryo at high altitude
    • Smith AH, Burton RR, and Besch EL. Development of the chick embryo at high altitude. Fed Proc 28: 1092-1098, 1969.
    • (1969) Fed Proc , vol.28 , pp. 1092-1098
    • Smith, A.H.1    Burton, R.R.2    Besch, E.L.3
  • 56
    • 0023359373 scopus 로고
    • Umbilical cord compression produces pulmonary hypertension in newborn lambs: A model to study the pathophysiology of persistent pulmonary hypertension in the newborn
    • Soifer SJ, Kaslow D, Roman C, and Heymann MA. Umbilical cord compression produces pulmonary hypertension in newborn lambs: a model to study the pathophysiology of persistent pulmonary hypertension in the newborn. J Dev Physiol 9: 239-252, 1987.
    • (1987) J Dev Physiol , vol.9 , pp. 239-252
    • Soifer, S.J.1    Kaslow, D.2    Roman, C.3    Heymann, M.A.4
  • 57
    • 0030727379 scopus 로고    scopus 로고
    • Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation
    • Steinhorn RH, Morin 3rd FC, and Fineman JR. Models of persistent pulmonary hypertension of the newborn (PPHN) and the role of cyclic guanosine monophosphate (GMP) in pulmonary vasorelaxation. Semin Perinatol 21: 393-408, 1997.
    • (1997) Semin Perinatol , vol.21 , pp. 393-408
    • Steinhorn, R.H.1    Morin III, F.C.2    Fineman, J.R.3
  • 58
    • 0034011190 scopus 로고    scopus 로고
    • Brief perinatal hypoxia increases severity of pulmonary hypertension after reexposure to hypoxia in infant rats
    • Tang JR, Le Cras TD, Morris KG Jr, and Abman SH. Brief perinatal hypoxia increases severity of pulmonary hypertension after reexposure to hypoxia in infant rats. Am J Physiol Lung Cell Mol Physiol 278: L356-L364, 2000.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278
    • Tang, J.R.1    Le Cras, T.D.2    Morris Jr., K.G.3    Abman, S.H.4
  • 59
    • 0019486960 scopus 로고
    • 2, He, and SF6 on chick embryo blood pressure and heart rate
    • 2, He, and SF6 on chick embryo blood pressure and heart rate. J Appl Physiol 51: 1017-1022, 1981.
    • (1981) J Appl Physiol , vol.51 , pp. 1017-1022
    • Tazawa, H.1
  • 60
    • 0031747165 scopus 로고    scopus 로고
    • Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension
    • Van Suylen RJ, Smits JF, and Daemen MJ. Pulmonary artery remodeling differs in hypoxia- and monocrotaline-induced pulmonary hypertension. Am J Respir Crit Care Med 157: 1423-1428, 1998.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 1423-1428
    • Van Suylen, R.J.1    Smits, J.F.2    Daemen, M.J.3
  • 61
    • 0027260829 scopus 로고
    • Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies
    • Veille JC, Hanson R, Sivakoff M, Hoen H, and Ben-Ami M. Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies. Am J Perinatol 10: 275-279, 1993.
    • (1993) Am J Perinatol , vol.10 , pp. 275-279
    • Veille, J.C.1    Hanson, R.2    Sivakoff, M.3    Hoen, H.4    Ben-Ami, M.5
  • 62
    • 4143110054 scopus 로고    scopus 로고
    • Normal endothelium-dependent relaxation in pulmonary arteries of chicken embryos prone to pulmonary hypertension
    • Villamor E, Kessels CG, Vereijken A, De Mey JG, and Blanco CE. Normal endothelium-dependent relaxation in pulmonary arteries of chicken embryos prone to pulmonary hypertension (Abstract). Pediatr Res 52: 786, 2002.
    • (2002) Pediatr Res , vol.52 , pp. 786
    • Villamor, E.1    Kessels, C.G.2    Vereijken, A.3    De Mey, J.G.4    Blanco, C.E.5


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