Ion and diuretic specificity of chimeric proteins between apical Na +-K+-2Cl- and Na+-Cl- cotransporters

American Journal of Physiology - Renal Physiology

Volumn 287, Issue 3 56-3, 2004, Pages

  Tovar Palacio, Claudia ^a   Bobadilla, Norma A ^a   Cortés, Paulina ^a   Plata, Consuelo ^a   De Los Heros, Paola ^a   Vázquez, Norma ^a   Gamba, Gerardo ^a,b  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

^b UNIVERSIDAD LA SALLE   (Mexico)

Author keywords

Bumetanide; Chimeras; Cotransporter; Salt reabsorption; Thiazide

Indexed keywords

BUMETANIDE; CHIMERIC PROTEIN; CHLORIDE; POTASSIUM ION; SODIUM ION; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; THIAZIDE DIURETIC AGENT;

ANIMAL CELL; ARTICLE; BARTTER SYNDROME; BINDING AFFINITY; CHLORIDE TRANSPORT; CONTROLLED STUDY; DIURESIS; GENE MUTATION; GITELMAN SYNDROME; HENLE LOOP; HETEROLOGOUS EXPRESSION; ION TRANSPORT; KIDNEY DISTAL TUBULE; NONHUMAN; PRIORITY JOURNAL; SODIUM ABSORPTION; XENOPUS LAEVIS;

EID: 4143127549     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00124.2004     Document Type: Article

References (47)

1. Arbuckle MI, Kane S, Porter LM, Scatter MJ, and Gould GW. Structure-function analysis of liver-type (GLUT2) and brain-type (GLUT3) glucose transporters: expression of chimeric transporters in Xenopus oocytes suggests an important role for putative transmembrane helix 7 in determining substrate selectivity. Biochemistry 35: 16519-16527, 1996.
2. 2+- and voltage-activated potassium channels. J Biol Chem 276: 42116-42121, 2001.
3. + channel activity. J Biol Chem 272: 6548-6555, 1997.
4. Chapell R, Bueno OF, Alvarez-Hernandez X, Robinson LC, and Leidenheimer NJ. Activation of protein kinase C induces γ-aminobutyric acid type A receptor internalization in Xenopus oocytes. J Biol Chem 273: 32595-32601, 1998.
5. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, and Roccella EJ. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 289: 2560-2571, 2003.
6. Dumont JN. Oogenesis in Xenopus laevis (Daudin). Stages of oocyte development in laboratory maintained animals. J Morphol 136: 153-180, 1970.
7. Ellison DH. Diuretic drugs and the treatment of edema: from clinic to bench and back again. Am J Kidney Dis 23: 623-643, 1994.
8. Ellison DH, Velazquez H, and Wright FS. Thiazide-sensitive sodium chloride cotransport in early distal tubule. Am J Physiol Renal Fluid Electrolyte Physiol 253: F546-F554, 1987.
9. Eveloff J and Calamia J. Effect of osmolarity on cation fluxes in medullary thick ascending limb cells. Am J Physiol Renal Fluid Electrolyte Physiol 250: F176-F180, 1986.
10. Gamba G, Miyanoshita A, Lombardi M, Lytton J, Lee WS, Hediger MA, and Hebert SC. Molecular cloning, primary structure and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney. J Biol Chem 269: 17713-17722, 1994.
11. Gamba G, Saltzberg SN, Lombardi M, Miyanoshita A, Lytton J, Hediger MA, Brenner BM, and Hebert SC. Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter. Proc Natl Acad Sci USA 90: 2749-2753, 1993.
12. Gimenez I, Isenring P, and Forbush B III. Spatially distributed alternative splice variants of the renal Na-K-Cl cotransporter exhibit dramatically different affinities for the transported ions. J Biol Chem 277: 8767-8770, 2002.
13. +, a prerequisite for active NaCl transport in the conical thick ascending limb of Henlen's loop of rabbit kidney. Pflügers Arch 392: 92-94, 1981.
14. Hebert SC, Culpepper RM, and Andreoli TE. NaCl transport in mouse medullary thick ascending limbs. III. Modulation of ADH effect by peritubular osmolality. Am J Physiol Renal Fluid Electrolyte Physiol 241 : F443-F451, 1981.
15. - cotransporter. J Am Soc Nephrol 14: 271-282, 2003.
16. Isenring P and Forbush B III. Ion and bumetanide binding by the Na-K-Cl cotransporter. Importance of transmembrane domains. J Biol Chem 272: 24556-24562, 1997.
17. Isenring P and Forbush B. Ion transport and ligand binding by the Na-K-Cl cotransporter, structure-function studies. Comp Biochem Physiol A 130: 487-497, 2001.
18. Isenring P, Jacoby SC, Chang J, and Forbush B III. Mutagenic mapping of the Na-K-Cl cotransporter for domains involved in ton transport and bumelanide binding. J Gen Physiol 112: 549-558, 1998.
19. Isenring P, Jacoby SC, and Forbush B III. The role of transmembrane domain 2 in calion transport by the Na-K-Cl cotransporter. Proc Natl Acad Sci USA 95: 7179-7184, 1998.
20. Isenring P, Jacoby SC, Payne JA, and Forbush B III. Comparison of Na-K-Cl cotransporters. NKCC1, NKCC2, and the HEK Cell Na-K-Cl cotransporter. J Biol Chem 273: 11295-11301, 1998.
21. Janecki AJ, Janecki M, Akhter S, and Donowitz M. Basic fibroblasl growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase. J Biol Chem 275: 8133-8142, 2000.
22. Janecki AJ, Janecki M, Akhter S, and Donowitz M. Quantitation of plasma membrane expression of a fusion protein of Na/H exchanger NHE3 and green fluorescence protein (GFP) in living PSI 20 fibroblasts. J Histochem Cytochem 48: 1479-1492, 2000.
23. Ji HL, Chalfant ML, Jovov B, Lockhart JP, Parker SB, Fuller CM, Stanton BA, and Benos DJ. The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel. J Biol Chem 275: 27947-27956, 2000.
24. Kaplan MR, Plotkin MD, Lee W-S, Xu Z-C, Lytton J, and Hehert SC. Apical localization of the Na-K-Cl cotransporter, rBSCl, on rat thick ascending limbs. Kidney Int 49: 40-47, 1996.
25. Kurtz CL, Karolyi L, Seyberth HW, Koch MC, Vargas R, Feldmann D, Vollmer M, Knoers NV, Madrigal G, and Guay-Woodford LM. A common NKCC2 mutation in Costa Rican Bartter's syndrome patients: evidence for a founder effect. J Am Soc Nephrol 8: 1706-1711, 1997.
26. Mastroianni N, Bettinelli A, Bianchetti M, Colussi G, de Fusco M, Sereni F, Ballabio A, and Casari G. Novel molecular variants of the Na-Cl cotransporter gene are responsible for Gitelman syndrome. Am J Hum Genet 59: 1019-1026, 1996.
27. - cotransporter is mediated by regulation of cotransporter trafficking. Am J Physiol Renal Physiol 284: F1145-F1154, 2003.
28. - cotransporter: a new model for ions and diuretics interaction. Am J Physiol Renal Physiol 279: F161-F169, 2000.
29. -cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity. J Biol Chem 279: 16553-16560, 2004.
30. Mount DB, Baekgard A, Hall AE, Plata C, Xu J, Beier DR, Gamba G, and Hebert SC. Isoforms of the Na-K-2Cl transporter in murine TAL I. Molecular characterization and intrarenal localization. Am J Physiol Renal Physiol 276: F347-F358, 1999.
31. Noel LE and Newgard CB. Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras. Biochemistry 36: 5465-5475, 1997.
32. Petrecca K, Atanasiu R, Akhavan A, and Shrier A. N-linked glycosylation sites determine HERG channel surface membrane expression. J Physiol 515: 41-48, 1999.
33. Plata C, Meade P, Hall AE, Welch RC, Vazquez N, Hebert SC, and Gamba G. Alternatively spliced isoform of the apical Na-K-Cl cotransporter gene encodes a furosemide sensitive Na-Cl cotransporter. Am J Physiol Renal Physiol 280: F574-F582, 2001.
34. Plata C, Mount DB, Rubio V, Hebert SC, and Gamba G. Isoforms of the Na-K-2Cl cotransporter in murine TAL. II. Functional characterization and activation by cAMP. Am J Physiol Renal Physiol 276: F359-F366, 1999.
35. - cotransporter isoforms. J Biol Chem 277: 11004-11012, 2002.
36. Plotkin MD, Kaplan MR, Verlander JM, Lee W-S, Brown D, Poch E, Gullans SR, and Hebert SC. Localization of the thiazide sensitive Na-Cl cotransporter, rTSCl, in the rat kidney. Kidney Int 50: 174-183, 1996.
37. Rossier BC. Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension? J Clin Invest 111: 947-950, 2003.
38. Sabath S, Meade P, Berkman J, de los Heron P, Moreno E, Bobadilla NA, Vazquez N, Ellison DH, and Gamba G. Pathophystology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. Am J Physiol Renal Physiol 10.1152/ajprenal.00044.2004.
39. Simon DB, Karet FE, Hamdan JM, Di Pietro A, Sanjad SA, and Lifton RP. Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet 13: 183-188, 1996.
40. Simon DB, Nelson-Williams C, Johnson-Bia M, Ellison D, Karet FE, Morey-Molina A, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitelman HJ, and Lifton RP. Gitelman's variant of Banter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 12: 24-30, 1996.
41. - cotransport in mouse medullary thick ascending limb. J Membr Biol 120: 83-94, 1991.
42. Wallner M, Meera P, and Toro L. Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog. Proc Natl Acad Sci USA 96: 4137-4142, 1999.
43. Wang XY, Masilamani S, Nielsen J, Kwon TH, Brooks HL, Nielsen S, and Knepper MA. The renal thiazide-sensitive Na-Cl cotransporter as mediator of the aldosterone-escape phenomenon. J Clin Invest 108: 215-222, 2001.
44. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, and Lifton RP. Human hypertension caused by mutations in WNK kinases. Science 293: 1107-1112, 2001.
45. Wilson FH, Kahle KT, Sabath E, Lalloti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, and Lifton RP. Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Nat Acad Sci USA 100: 680-684, 2003.
46. Xia XM, Ding JP, and Lingle CJ. Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells. J Neuritsci 19: 5255-5264, 1999.
47. Yang CL, Angell J, Mitchell R, and Ellison DH. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111: 1039-1045, 2003.