Gelsolin gene silencing involving unusual hypersensitivities to dimethylsulfate and KMnO4 in vivo footprinting on its promoter region

International Journal of Cancer

Volumn 111, Issue 6, 2004, Pages 873-880

  Haga, Kazunori ^a,b   Fujita, Hisakazu ^a   Nomoto, Minoru ^c   Sazawa, Ataru ^a,b   Nakagawa, Koji ^a   Harabayashi, Toru ^b   Shinohara, Nobuo ^b   Takimoto, Masato ^a   Nonomura, Katsuya ^b   Kuzumaki, Noboru ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Bladder cancer; Dimethylsulfate hypersensitivity; Gelsolin; Gene silencing; In vivo footprinting

Indexed keywords

DIMETHYL SULFATE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HISTONE H4; NUCLEOTIDE; PERMANGANATE POTASSIUM; TRICHOSTATIN A;

ACETYLATION; ARTICLE; BLADDER CANCER; CANCER CELL; CANCER CELL CULTURE; CONTROLLED STUDY; DEACETYLATION; DNA FOOTPRINTING; DOWN REGULATION; DRUG SENSITIVITY; GELSOLIN GENE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VIVO STUDY; NUCLEOSOME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; UNTRANSLATED REGION;

BASE SEQUENCE; CHROMATIN; DNA FOOTPRINTING; DNA METHYLATION; DOWN-REGULATION; GELSOLIN; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENS; POLYMERASE CHAIN REACTION; POTASSIUM PERMANGANATE; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); SULFURIC ACID ESTERS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 4143079403     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.20348     Document Type: Article

References (38)

1. Rountree MR, Bachman KE, Herman JG, Baylin SB. DNA methylation, chromatin inheritance, and cancer. Oncogene 2001;20:3156-65
2. Baylin SB, Esteller M, Rountree MR, Bachman KE, Schuebel K, Herman JG. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genetics 2001;10:687-92.
3. Moriya S, Yanagihara K, Fujita H, Kuzumaki N. Differential expression of HSP90 gelsolin and GST-π in human gastric carcinoma cell lines. Int J Oncol 1994;5:1347-51.
4. Tanaka M, Mullauer L, Ogiso Y, Fujita H, Moriya S, Furuuchi K, Harabayashi T, Shinohara N, Koyanagi T, Kuzumaki N. Gelsolin: a candidate for suppressor of human bladder cancer. Cancer Res 1995;55:3228-32.
5. Furuuchi K, Fujita H, Tanaka M, Shichinohe T, Senmaru N, Ogiso Y, Moriya S, Hamada M, Katoh H, Kuzumaki N. Gelsolin as a suppressor of malignant phenotype in human colon cancer. Tumor Target 1996;2:277-83.
6. Akita DH, Hommura F, Fujita H, Kinoshita I, Nishi M, Morikawa T, Katoh H, Kawakami Y, Kuzumaki N. Frequent loss of gelsolin expression in non-small cell lung cancers of heavy smokers. Cancer Res 1998;58:322-7.
7. Sagawa N, Fujita H, Banno Y, Nozawa Y, Kaloh H, Kuzumaki N. Gelsolin suppresses tumorigenicity through inhibiting PKC activation in a human lung cancer cell line, PC10. Br J Cancer 2003;88:606-12.
8. Asch HL, Head K, Dong Y, Natori F, Winston JS, Connoly JL, Asch BB. Widespread loss of gelsolin in breast cancers in humans, mice, and rats. Cancer Res 1996;56:4841-5.
9. Lee HK, Driscoll D, Asch H, Asch B, Zhang PJ. Downregulated gelsolin expression in hyperplastic and neoplastic lesions of the prostate. Prostate 1999;40:14-9.
10. Shieh DB, Godleski J, Herndon JE II, Azuma T, Mercer H, Sugarbaker DJ, Kwiatkowski DJ. Cell motility as a prognostic factor in Stage I nonsmall cell lung carcinoma: the role of gelsolin expression. Cancer 1999;85:47-57.
11. Rao J, Seligson D, Visapaa H, Horvath S, Eeva M, Michel K, Pantuck A, Belldegrun A, Palotie A. Tissue microarray analysis of cytoskeletal actin-associated biomarkers gelsolin and E-cadherin in urothelial carcinoma. Cancer 2002;95:1247-57.
12. De Corte V, Bruyneel E, Boucherie C, Mareel M, Vandekerckhove J, Gettemans J. Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling. EMBO J 2002;21:6781-90.
13. Mielnicki LM, Ving AM, Head KL, Asch HL, Asch BB. Epigenetic regulation of gelsolin expression in human breast cancer cells. Exp Cell Res 1999;249:161-76.
14. Hoshikawa Y, Kwon HJ, Yoshida M, Horinouchi S, Beppu T. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines. Exp Cell Res 1994;214:189-97.
15. Han JW, Ahn SH, Park SH, Wang SY, Bae GU, Seo DW, Kwon HK, Hong S, Lee HY, Lee YW, Lee HW. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res 2000;60:6068-74.
16. Shannon MF. A nuclear address with influence. Nat Genet 2003;34:4-6.
17. Truschel ST, Ruiz WG, Shulman T, Pilewski J, Sun TT, Zeidel ML, Apodaca G. Primary uroepithelial cultures: a model system to analyze umbrella cell barrier function. J Biol Chem 1999;274:15020-9.
18. Watanabe T, Shinohara N, Moriya K, Sazawa A, Kobayashi Y, Ogiso Y, Takiguchi M, Yasuda J, Koyanagi T, Kuzumaki N, Hashimoto A. Significance of the Grb2 and son of sevenless (Sos) proteins in human bladder cancer cell lines. IUBMB Life 2000;49:317-20.
19. Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem 2000;275:15343-9.
20. Mueller PR, Wold B. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science 1989;246:780-6.
21. +-ATPase alpha 1 subunit gene by in vivo footprinting. Biochim Biophys Acta 1995;1264:35-9.
22. Maxam AM, Gilbert W. A new method for sequencing DNA. Proc Natl Acad Sci USA 1977;74:561-4.
23. Nomoto M, Izumi H, Ise T, Kato K, Takano H, Nagatani G, Shibao K, Ohta R, Imamura T, Kuwano M, Matsuo K, Yamada Y, et al. Structural basis for the regulation of UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase-3 gene expression in adenocarcinoma cells. Cancer Res 1999;59:6214-22.
24. Kwiatkowski DJ, Mehi R, Yin HL. Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin. J Cell Biol 1988;106:375-84.
25. Hornstra IK, Yang TP. In vivo footprinting and genomic sequencing by ligation-mediated PCR. Anal Biochem 1993;213:179-93.
26. Nagatani G, Nomoto M, Takano H, Ise T, Kato K, Imamura T, Izumi H, Makishima K, Kohno K. Transcriptional activation of the human HMG1 gene in cisplatin-resistant human cancer cells. Cancer Res 2001;61:1592-7.
27. Wolffe AP. Chromatin remodeling: why it is important in cancer. Oncogene 2001;20:2988-90.
28. Thykjaer T, Workman C, Kruhoffer M, Demtroder K, Wolf H, Andersen LD, Frederiksen CM, Knudsen S, Orntoft TF. Identification of gene expression patterns in superficial and invasive human bladder cancer. Cancer Res 2001;61:2492-9.
29. Serth J, Kuczyk M, Machiens S, Bokemeyer C, Hermann R, Hartmann J, Knuchel R, Jonas U. Analysis of the cyclin-dependent kinase inhibitor p27KipI in muscle invasive bladder cancer. Oncol Rep 1999;6:229-33.
30. Mielnicki LM, Asch HL, Asch BB. Genes, chromatin, and breast cancer: an epigenetic tale. J Mamm Gland Biol Neoplasia 2001;6:169-82.
31. Dong Y, Asch HL, Ying A, Asch BB. Molecular mechanism of transcriptional repression of gelsolin in human breast cancer cells. Exp Cell Res 2002;276:328-36.
32. Gidoni D, Dynan WS, Tjian R. Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature 1984;312:409-13.
33. Rodrigo I, Cato AC, Cano A. Regulation of E-cadherin gene expression during tumor progression: the role of a new Ets-binding site and the E-pal element. Exp Cell Res 1999;248:358-71.
34. Bouwman P, Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol Cell Endocrinol 2002;195:27-38.
35. Roman DG, Toledano MB, Leonard WJ. Sp1 represses IL-2 receptor alpha chain gene expression. New Biol 1990;7:642-7.
36. Shou Y, Baron S, Poncz M. An Sp1-binding silencer element is a critical negative regulator of the megakaryocyte-specific alpha II b gene. J Biol Chem 1998;273:5716-26.
37. Ogra Y, Suzuki K, Gong P, Otsuka F, Koizumi S. Negative regulatory role of Sp1 in metal responsive element-mediated transcriptional activation. J Biol Chem 2001;276:16534-9.
38. Murata Y, Kim HG, Rogers KT, Udvadia AJ, Horowitz JM. Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain. J Biol Chem 1994;269:20674-81.