Significance of the Grb2 and son of sevenless (SOS) proteins in human bladder cancer cell lines

IUBMB Life

Volumn 49, Issue 4, 2000, Pages 317-320

  Watanabe, Takafumi ^a   Shinohara, Nobuo ^b   Moriya, Kimihiko ^b   Sazawa, Ataru ^b   Kobayashi, Yoshiyasu ^a   Ogiso, Yoshifumi ^c   Takiguchi, Mitsuyoshi ^a   Yasuda, Jun ^a   Koyanagi, Tomohiko ^b   Kuzumaki, Noboru ^b   Hashimoto, Akira ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c NAGANO CHILDREN'S HOSPITAL   (Japan)

Author keywords

EGF receptor; Grb2 protein; Human bladder cancer; Ras oncogene; Son of sevenless protein

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; CANCER CELL CULTURE; HUMAN; HUMAN CELL; POINT MUTATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

EID: 0033919474     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540050033195     Document Type: Article

References (18)

1. Berger, M. S., Greenfield, C., Gullick, W. J., Haley, J., Downward, J., Neal, D. E., Harris, A. L., and Waterfield, M. D. (1987) Evaluation of epidermal growth factor receptors in bladder tumours. Br. J. Cancer 56, 533-537.
2. Neal, D. E., Sharples, L., Smith, K., Fennelly, J., Hall, R. R., and Harris, A. L. (1990) The epidermal growth factor receptor and the prognosis of bladder cancer. Cancer 65, 1619-1625.
3. Chow, N. H., Liu, H. S., Yang, H. B., Chan, S. H., and Su, I. J. (1997) Expression patterns of erbB receptor family in normal urothelium and transitional cell carcinoma. An immunohistochemical study. Virchows Arch. 430, 461-466.
4. Messing, E. M. (1990) Clinical implications of the expression of epidermal growth factor receptors in human transitional cell carcinoma. Cancer Res. 50, 2530-2537.
5. Sidransky, D., and Messing, E. (1992) Molecular genetics and biochemical mechanisms in bladder cancer. Oncogenes, tumor suppressor genes, and growth factors. Urol. Clin. North Am. 19, 629-639.
6. Boguski, M. S., and McCormick, F. (1993) Proteins regulating Ras and its relatives. Nature 366, 643-654.
7. Chardin, P., Camonis, J. H., Gale, N. W., van, A. L., Schlessinger, J., Wigler, M. H., and Bar, S. D. (1993) Human Sos1: A guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260, 1338-1343.
8. Daly, R. J., Binder, M. D., and Sutherland, R. L. (1994) Overexpression of the Grb2 gene in human breast cancer cell lines. Oncogene 9, 2723-2727.
9. Shinohara, N., Ogiso, Y., Tanaka, M., Sazawa, A., Harabayashi, T., and Koyanagi, T. (1997) The significance of Ras guanine nucleotide exchange factor, son of sevenless protein, in renal cell carcinoma cell lines. J. Urol. 158, 908-911.
10. Senger, D. R., Perruzzi, C. A., and Ali, I. U. (1988) T24 human bladder carcinoma cells with activated Ha-ras protooncogene: Nontumorigenic cells susceptible to malignant transformation with carcinogen. Proc. Natl. Acad. Sci. U.S.A. 85, 5107-5111.
11. Tachibana, M., Miyakawa, A., Uchida, A., Murai, M., Eguchi, K., Nakamura, K., Kubo, A., and Hata, J. I. (1997) Granulocyte colony-stimulating factor receptor expression on human transitional cell carcinoma of the bladder Br. J. Cancer 75, 1489-1496.
12. Grossman, H. B., Wedemeyer, G., and Ren, L. (1984) UM-UC-1 and UM-UC-2: Characterization of two new human transitional cell carcinoma lines. J. Urol. 132, 834-837.
13. Truschel, S. T., Ruiz, W. G., Shulman, T., Pilewski, J., Sun, T. T., Zeidel, M. L., and Apodaca, G. (1999) Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function. J. Biol. Chem. 274, 15020-15029.
14. Miller, S. A., Dykes, D. D., and Polesky, H. F. (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16, 1215.
15. Pawson, T. (1995) Protein modules and signalling networks. Nature 373, 573-580.
16. Buday, L., and Downward, J. (1993) Epidermal growth factor regulates p21 ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73, 611-620.
17. Aronheim, A., Engelberg, D., Li, N., al-Alawi, N., Schlessinger, J., and Karin, M. (1994) Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell 78, 949-961.
18. Skolnik, E. Y., Batzer, A., Li, N., Lee, C. H., Lowenstein, E., Mohammadi, M., Margolis, B., and Schlessinger, J. (1993) The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science 260, 1953-1955.