Blocking the L-type Ca2+ channel with a Gem: A paradigm for a more specific Ca2+ channel blocker

Circulation Research

Volumn 95, Issue 4, 2004, Pages 337-339

  Balijepalli, Ravi C ^a   Foell, Jason D ^a   Kamp, Timothy J ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of Wisconsin Health   (United States)

Author keywords

Calcium channel blocker; Gem; Gene therapy; L type Ca2+ channel; RGK protein

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; GUANOSINE TRIPHOSPHATASE; PROTEIN GEM; UNCLASSIFIED DRUG;

ANGINA PECTORIS; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; CALCIUM CURRENT; CHANNEL GATING; CONSTIPATION; DIZZINESS; DRUG MECHANISM; DRUG POTENCY; EDITORIAL; GENE THERAPY; GUINEA PIG; HEADACHE; HEART ARRHYTHMIA; HEART ATRIOVENTRICULAR NODE; HUMAN; HYPERTENSION; INOTROPISM; NONHUMAN; PERIPHERAL EDEMA; PRIORITY JOURNAL;

ADENOVIRIDAE; ANIMALS; ATRIAL FIBRILLATION; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DRUG DESIGN; GENE THERAPY; GENETIC VECTORS; GUANOSINE TRIPHOSPHATE; GUINEA PIGS; HEART CONDUCTION SYSTEM; IMMEDIATE-EARLY PROTEINS; ION CHANNEL GATING; MODELS, BIOLOGICAL; MONOMERIC GTP-BINDING PROTEINS; MULTIGENE FAMILY; PROTEIN SUBUNITS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SUS SCROFA;

EID: 4143060399     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000141018.33292.21     Document Type: Editorial

References (16)

1. Murata Y, Cingolani E, McDonald AD, Donahue JK, Marbán E. Creation of a genetic calcium channel blocker by targeted Gem gene transfer in the heart. Circ Res. 2004;95:398-405.
2. 2+ channels. Annu Rev Cell Dev Biol. 2000;16:521-555.
3. Foell JD, Balijepalli RC, Delisle BP, Yunker AM, Robia SL, Walker JW, McEnery MW, January CT, Kamp TJ. Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization. Physiol Genomics. 2004;17:183-200.
4. 1c in a human embryonic kidney cell line. J Physiol. 1996;492:89-96.
5. 2+ channel alpha1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit. Neuron. 2000;25:177-190.
6. McGee AW, Nunziato DA, Maltez JM, Prehoda KE, Pitt GS, Bredt DS. Calcium channel function regulated by the SH3-GK module in beta subunits. Neuron. 2004;42:89-99.
7. 2+ channels. Proc Natl Acad Sci U S A. 2004;101:7193-7198.
8. Van Petegem F, Clark KA, Chatelain FC, Minor DL Jr. Structure of a complex between a voltage-gated calcium channel beta-subunit and an alpha-subunit domain. Nature. 2004;429:671-675.
9. 2+ channels. Nature. 2004;429:675-680.
10. Opatowsky Y, Chen CC, Campbell KP, Hirsch JA. Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain. Neuron. 2004;42:387-399.
11. 2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature. 2001;411:701-706.
12. Finlin BS, Crump SM, Satin J, Andres DA. Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. Proc Natl Acad Sci U S A. 2003;100:14469-14474.
13. Ward Y, Spinelli B, Quon MJ, Chen H, Ikeda SR, Kelly K. Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. Mol Cell Biol. 2004;24:651-661.
14. Fischer R, Wei Y, Anagli J, Berchtold MW. Calmodulin binds to and inhibits GTP binding of the ras-like GTPase Kir/Gem. J Biol Chem. 1996;271:25067-25070.
15. 2+ channel Cav1.2. Science. 2001;293:98-101.
16. 2+ channels. Science. 2004;304:432-435.