Influence of oat saponins on intestinal permeability in vitro and in vivo in the rat

British Journal of Nutrition

Volumn 76, Issue 1, 1996, Pages 141-151

  Önning, Gunilla ^a   Wang, Quan ^a   Weström, Björn R ^a   Asp, Nils Georg ^a   Karlsson, Börje W ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Intestinal permeability; Oats; Saponins

Indexed keywords

BOVINE SERUM ALBUMIN; EDETIC ACID; GLUCOSE; MANNITOL; MARKER; OVALBUMIN; SAPONIN; 3 METHYLGLUCOSE; BIOLOGICAL MARKER; METHYLGLUCOSIDE;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD; CONTROLLED STUDY; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; OAT; RAT; SEROSA; URINE; ANIMAL; DRUG EFFECT; IN VITRO STUDY; INTESTINE ABSORPTION; METABOLISM; SPRAGUE DAWLEY RAT;

3-O-METHYLGLUCOSE; ANIMALS; AVENA SATIVA; BIOLOGICAL MARKERS; BIOLOGICAL TRANSPORT, ACTIVE; EDETIC ACID; INTESTINAL ABSORPTION; MALE; MANNITOL; METHYLGLUCOSIDES; OVALBUMIN; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS;

EID: 0029665191     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/bjn19960016     Document Type: Article

References (26)

1. Atkinson, H. A. C., Grogoriadou, F. & Miller, K. (1994). Enhancement of oral sensitisation to food allergens by the bioactive plant constituent Gypsophila saponin in the brown Norway rat. In Biochemical Biomarkers in Environmental Toxicology, Abstract Booklet. Cambridge: University of Cambridge.
2. Gee, J. M. & Johnson, I. T. (1988). Interactions between hemolytic saponins, bile acids and small intestinal mucosa in the rat. Journal of Nutrition 118, 1391-1397.
3. Gee, J. M., Price, K. R., Ridout, C. L., Wortley, G. M., Hurrell, R. F. & Johnson, I. T. (1993). Saponins of quinoa (Chenopodium quinoa): effects of processing on their abundance in quinoa products and their biological effects on intestinal mucosal tissue. Journal of the Science of Food and Agriculture 63, 201-209.
4. Gestetner, B., Birk, Y. & Tencer, Y. (1968). Fate of ingested soybean saponins and the physiological aspect of their hemolytic activity. Journal of Agricultural and Food Chemistry 16, 1031-1035.
5. Hamilton, I., Rothwell, J., Archer, D. & Axon, A. T. R. (1987). Permeability of the rat small intestine to carbohydrate probe molecules. Clinical Science 73, 189-196.
6. Johnson, I. T., Gee, J. M., Price, K., Curl, C. & Fenwick, G. R. (1986). Influence of saponins on gut permeability and active nutrient transport in vitro. Journal of Nutrition 116, 2270-2277.
7. Lalitha, T., Vishwanatha, S. & Venkataraman, L. V. (1990). Oral toxicity of Modhuca butyracea Macb. saponins to albino rats. Indian Journal of Experimental Biology 28, 642-647.
8. Mohr, W. (1953). Über die Qualitätsbeeinflussung von Hafererzeugnissen (III) Vorbericht über einen wasserlöslichen Bitterstoff aus Hafer (Influence on the quality of oat products (III). A preliminary report of a water soluble, bitter tasting compound in oats). Deutsche Lebensmittel-Rundschau 49, 127-131.
9. Oakenfull, D. G. & Sidhu, G. S. (1990). Could saponins be a useful treatment for hypercholesterolaemia? European Journal of Clinical Nutrition 44, 79-88.
10. Oleszek, W. (1990). Structural specificity of alfalfa (Medicago sativa) saponin haemolysis and its impacts on two haemolysis-based quantification methods. Journal of the Science of Food and Agriculture 53, 477-485.
11. Oleszek, W., Jurzysta, M., Ploszynski, M., Colquhoun, I. J., Price, K. R. & Fenwick, G. R. (1992). Zahnic acid tridesmoside and other dominant saponins from alfalfa (Medicago sativa L.) aerial parts. Journal of Agricultural and Food Chemistry 40, 191-196.
12. Oleszek, W., Nowacka, J., Gee, J. M., Wortley, G. M. & Johnson, I. T. (1994). Effects of some purified alfalfa (Medicago sativa) saponins on transmural potential difference in mammalian small intestine. Journal of the Science of Food and Agriculture 65, 35-39.
13. Önning, G. & Asp, N.-G. (1993). Analysis of saponins in oat kernels. Food Chemistry 48, 301-305.
14. Önning, G. & Asp, N.-G. (1995). Effect of oat saponins on plasma and liver lipids in gerbils and rats. British Journal of Nutrition 73, 275-286.
15. Önning, G., Asp, N.-G. & Sivik, B. (1993). Saponin content in different oat varieties and in different fractions of oat grain. Food Chemistry 48, 251-254.
16. Pantzar, N., Weström, B. R., Luts, A. & Lundin, S. (1993), Regional small-intestinal permeability in vitro to different-sized dextrans and proteins in the rat. Scandinavian Journal of Gastroenterology 28, 205-211.
17. Price, K. R., Johnson, I. T. & Fenwick, G. R. (1987). The chemistry and biological significance of saponins in foods and feedingstuffs. CRC Critical Reviews in Food Science and Nutrition 26, 27-135.
18. Rennard, S. I., Berg, R., Martin, G. R., Foidart, J. M. & Robey, P.G. (1980). Enzyme-linked immunoassay (ELISA) for connective tissue components. Analytical Biochemistry 104, 205-214.
19. Sanderson, I. R. & Walker, W. A. (1993). Uptake and transport of macromolecules by the intestine: possible role in clinical disorders (an update). Gastroenterology 104, 622-639.
20. Sidhu, G. S., Upson, B. & Malinow, M. R. (1987). Effects of soy saponins and tigogenin cellobioside on intestinal uptake of cholesterol, cholate and glucose. Nutrition Reports International 35, 615-623.
21. Tschesche, R. & Lauven, P. (1971). Avenacosid B, ein zweites bisdesmosidisches Steroidsaponin aus Avena sativa (Avenacoside B, a second bisdesmosidic steroid saponin from Avena sativa). Chemische Berichtung 104, 3549-3555.
22. Tschesche, R., Tauscher, M., Fehlhaber, H.-W. & Wulff, G. (1969). Avenacosid A, ein bisdesmosidisches Steroidsaponin aus Avena sativa (Avenacoside A, a bisdesmosidic steroid saponin from Avena sativa). Chemische Berichtung 102, 2072-2082.
23. Tschesche, R. & Wiemann, W. (1977). Desglucoavenacosid-A and -B, biologisch aktive Nuatigenin glycoside (Desglucoavenacoside A and B, biologically active nuatigenin glycosides). Chemische Berichtung 110, 2416-2423.
24. Tschesche, R. & Wulff, G. (1973). Chemie und Biologie der Saponine. (Chemistry and biology of saponins). Progress in the Chemistry of Organic Natural Products 30, 461-605.
25. Wall, M. E., Eddy, C. R., McClennan, M. L. & Klumpp, M. E. (1952). Detection and estimation of steroidal sapogenins in plant tissue. Analytical Chemistry 24, 1337-1341.
26. Wang, Q., Pantzar, N., Jeppsson, B., Weström, B. R. & Karlsson, B. W. (1994). Increased intestinal marker absorption due to regional permeability changes and decreased intestinal transit during sepsis in the rat. Scandinavian Journal of Gastroenterology 28, 1001-1008.