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4
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34547162349
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For the chemical synthesis of thapsigargin and leading references into its isolation and activity, see:
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For the chemical synthesis of thapsigargin and leading references into its isolation and activity, see:. Andrews S.P., Ball M., Wierschem F., Cleator E., Oliver S., Högenauer K., Simic O., Antonello A., Hünger U., Smith M.D., and Ley S.V. Chem. Eur. J. 13 (2007) 5688-5712
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0018942336
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For discussion and leading references, see:
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For discussion and leading references, see:. Christensen S.B., and Ramussen U. Tetrahedron Lett. 21 (1980) 3829-3830
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Christensen, S.B.1
Ramussen, U.2
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7
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41349103441
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note
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The molecular connectivity for the basiliolides was established largely through NMR spectroscopy. The absolute stereochemistry is unknown.
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8
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33749016046
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Navarrete C., Sancho R., Caballero F.J., Pollastro F., Fiebich B.L., Sterner O., Appendino G., and Muñoz E. J. Pharmacol. Exp. Ther. 319 (2006) 422-430
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Sancho, R.2
Caballero, F.J.3
Pollastro, F.4
Fiebich, B.L.5
Sterner, O.6
Appendino, G.7
Muñoz, E.8
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11
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41349098567
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note
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The stereogenic centers are at adjoining carbons. The contiguous nature of the stereocenters simplifies rather than confounds the problem.
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12
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41349114226
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Portions of this work have been presented: (a) Kozytska, M. V.; Dudley, G. B. Abstracts of Papers 58th Southeast Regional Meeting of the American Chemical Society, Augusta, GA, November 1-4, 2006; American Chemical Society; Washington, DC, 2006; SRM06 011.
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Portions of this work have been presented: (a) Kozytska, M. V.; Dudley, G. B. Abstracts of Papers 58th Southeast Regional Meeting of the American Chemical Society, Augusta, GA, November 1-4, 2006; American Chemical Society; Washington, DC, 2006; SRM06 011.
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13
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41349092299
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Kozytska, M. V.; Dudley, G. B. Abstracts of Papers 234th National Meeting of the American Chemical Society, Boston, MA, August 19-23, 2007; American Chemical Society; Washington, DC, 2007; ORGN 1012.
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Kozytska, M. V.; Dudley, G. B. Abstracts of Papers 234th National Meeting of the American Chemical Society, Boston, MA, August 19-23, 2007; American Chemical Society; Washington, DC, 2007; ORGN 1012.
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14
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0027054952
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Relevant applications of 5-halo-2-pyrones in Diels-Alder reactions:
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Relevant applications of 5-halo-2-pyrones in Diels-Alder reactions:. Afarinkia K., and Posner G.H. Tetrahedron Lett. 33 (1992) 7839-7842
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Afarinkia, K.1
Posner, G.H.2
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0037059504
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Cho C.-G., Kim Y.-W., Lim Y.-K., Park J.-S., Lee H., and Koo S. J. Org. Chem. 67 (2002) 290-293
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19
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0001587135
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Kita Y., Maeda H., Omori K., Okuno T., and Tamura Y. Synlett (1993) 273-274
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Kita, Y.1
Maeda, H.2
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Tamura, Y.5
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21
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41349083785
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note
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Although their report does not specifically address IMPDA reactions of 5-halo-2-pyrones, Nelson and Stoltz also highlighted their potential utility for the synthesis of basiliolide B (Ref. 13).
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22
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41349102558
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See Supplementary data for experimental procedures and data.
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See Supplementary data for experimental procedures and data.
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25
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0037124516
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Biagetti M., Bellina F., Carpita A., Stabile P., and Rossi R. Tetrahedron 58 (2002) 5023-5038
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Biagetti, M.1
Bellina, F.2
Carpita, A.3
Stabile, P.4
Rossi, R.5
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26
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0037450954
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Rossi R., Carpita A., Bellina F., Stabile P., and Mannina L. Tetrahedron 59 (2003) 2067-2081
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Rossi, R.1
Carpita, A.2
Bellina, F.3
Stabile, P.4
Mannina, L.5
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29
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41349083565
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note
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We elected to examine a three-carbon tethered substrate (13) rather than build Thorpe-Ingold assistance into a four-carbon tether.
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