Basiliolides, a class of tetracyclic C19 dilactones from Thapsia garganica, release Ca2+ from the endoplasmic reticulum and regulate the activity of the transcription factors nuclear factor of activated T cells, nuclear factor-κB, and activator protein 1 in T lymphocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 1, 2006, Pages 422-430

  Navarrete, Carmen ^a   Sancho, Rocío ^a   Caballero, Francisco J ^a   Pollastro, Federica ^b   Fiebich, Bernd L ^c   Sterner, Olov ^d   Appendino, Giovanni ^b   Muñoz, Eduardo ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c VIVACELL BIOTECHNOLOGY GMBH   (Germany)

^d LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BASILIOLIDE A1; BASILIOLIDE B; BASILIOLIDE C; CYCLOSPORIN A; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; LACTONE DERIVATIVE; N [4 [3,5 BIS(TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]PHENYL] 4 METHYL 1,2,3 THIADIAZOLE 5 CARBOXAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; SERINE; STRESS ACTIVATED PROTEIN KINASE; THAPSIGARGIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; COMPARATIVE STUDY; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOPLASMIC RETICULUM; EXTRACELLULAR CALCIUM; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEDICINAL PLANT; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; THAPSIA GARGANICA;

APIACEAE; APOPTOSIS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; ENDOPLASMIC RETICULUM; HUMANS; JURKAT CELLS; LACTONES; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

EID: 33749016046     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.108209     Document Type: Article

References (33)

1. Appendino G, Prosperini S, Valdivia C, Ballero M, Colombano G, Billington RA, Genazzani AA, and Sterner O (2005) SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis. J Nat Prod 68:1213-1217.
2. Benedito AB, Lehtinen M, Massol R, Lopes UG, Kirchhausen T, Rao A, and Bonni A (2005) The transcription factor NFAT3 mediates neuronal survival. J Biol Chem 280:2818-2825.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Crabtree GR and Clipstone NA (1994) Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem 63:1045-1083.
5. Engedal N, Korkmaz CG, and Saatcioglu F (2002) c-Jun N-terminal kinase is required for phorbol ester- and thapsigargin-induced apoptosis in the androgen responsive prostate cancer cell line LNCaP. Oncogene 21:1017-1027.
6. Feng W, Tu J, Yang T, Vernon PS, Allen PD, Worley PF, and Pessah IN (2002) Homer regulates gain of ryanodine receptor type 1 channel complex. J Biol Chem 277:44722-44730.
7. Feske S, Giltnane J, Dolmetsch R, Staudt LM, and Rao A (2001) Gene regulation mediated by calcium signals in T lymphocytes. Nat Immunol 2:316-324.
8. Fridmacher V, Kaltschmidt B, Goudeau B, Ndiaye D, Rossi FM, Pfeiffer J, Kaltschmidt C, Israel A, and Memet S (2003) Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. J Neurosci 23:9403-9408.
9. Hogan PG, Chen L, Nardone J, and Rao A (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17:2205-2232.
10. Irvin BJ, Williams BL, Nilson AE, Maynor HO, and Abraham RT (2000) Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol Cell Biol 20:9149-9161.
11. Jayaraman T and Marks AR (1997) T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol Cell Biol 17:3005-3012.
12. 2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin. Exp Cell Res 212:84-92.
13. Kaneko Y and Tsukamoto A (1994) Thapsigargin-induced persistent intracellular calcium pool depletion and apoptosis in human hepatoma cells. Cancer Lett 79:147-155.
14. Karin M and Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 18:621-663.
15. Lang F, Foller M, Lang KS, Lang PA, Ritter M, Gulbins E, Vereninov A, and Huber SM (2005) Ion channels in cell proliferation and apoptotic cell death. J Membr Biol 205:147-157.
16. Leonardi A, Vito P, Mauro C, Pacifico F, Ulianich L, Consiglio E, Formisano S, and Di Jeso B (2002) Endoplasmic reticulum stress causes thyroglobulin retention in this organelle and triggers activation of nuclear factor-kappa B via tumor necrosis factor receptor-associated factor 2. Endocrinology 143:2169-2177.
17. Lewis RS (2001) Calcium signaling mechanisms in T lymphocytes. Annu Rev Immunol 19:497-521.
18. Li Q and Verma IM (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2:725-734.
19. Macian F (2005) NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5:472-484.
20. Maloney JA, Tsygankova OM, Yang L, Li Q, Szot A, Baysal K, and Williamson JR (1999) Activation of ERK by Ca2+ store depletion in rat liver epithelial cells. Am J Physiol 276:221-230.
21. 2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes. J Biol Chem 266:20856-20862.
22. 2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO (Eur Mol Biol Organ) J 20:2690-2701.
23. Quintana A, Griesemer D, Schwarz EC, and Hoth M (2005) Calcium-dependent activation of T-lymphocytes. Pflueg Arch Eur J Physiol 450:1-12.
24. Rao A, Luo C, and Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707-747.
25. 2+ handling. J Biol Chem 271:29304-29311.
26. Rosado JA and Sage SO (2001) Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. J Biol Chem 276:15659-15665.
27. Sancho R, Macho A, de La Vega L, Calzado MA, Fiebich BL, Appendino G, and Munoz E (2004) Immunosuppressive activity of endovanilloids: N-arachidonoyldopamine inhibits activation of the NF-kappa B, NFAT, and activator protein 1 signaling pathways. J Immunol 172:2341-2351.
28. Shaw JP, Utz PJ, Durand DB, Toole JJ, Emmel EA, and Crabtree GR (1988) Identification of a putative regulator of early T cell activation genes. Science (Wash DC) 241:202-205.
29. Stiber JA, Tabatabaei N, Hawkins AF, Hawke T, Worley PF, Williams RS, and Rosenberg P (2005) Homer modulates NFAT-dependent signaling during muscle differentiation. Dev Biol 287:213-224.
30. 2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase. Proc Natl Acad Sci USA 87:2466-2470.
31. Treiman M, Caspersen C, and Christensen SB (1998) A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. Trends Pharmacol Sci 19:131-135.
32. Waldron RT, Short AD, Meadows JJ, Ghosh TK, and Gill DL (1994) Endoplasmic reticulum calcium pump expression and control of cell growth. J Biol Chem 269:11927-11933.
33. 2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J Biol Chem 279:12427-12437.