Physical stability of ternary solid dispersions of itraconazole in polyethyleneglycol 6000/hydroxypropylmethylcellulose 2910 E5 blends

International Journal of Pharmaceutics

Volumn 355, Issue 1-2, 2008, Pages 100-107

  Janssens, Sandrien ^a   Roberts, Clive ^b   Smith, Emily F ^b   Van den Mooter, Guy ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Dissolution; MTDSC; Solid dispersion; Spray drying; Stability; XPS

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; ITRACONAZOLE; MACROGOL 6000;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; HUMIDITY; PRIORITY JOURNAL; SPRAY DRYING; THERMOSTABILITY;

ANTIFUNGAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLIZATION; EXCIPIENTS; ITRACONAZOLE; METHYLCELLULOSE; POLYETHYLENE GLYCOLS; POLYMERS; SOLUBILITY; SPECTROMETRY, X-RAY EMISSION; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPERATURE;

EID: 41349084161     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.11.054     Document Type: Article

References (14)

1. Amidon G.L., Lennernäs H., Shah V.P., and Crison J.R. Theoretical basis for a biopharmaceutical drug classification; the correlation of in vivo drug product dissolution and in vivo bioavailability. Pharm. Res. 12 (1995) 413-420
2. Chiou W.L., and Riegelman S. Pharmaceutical applications of solid dispersions. J. Pharm. Sci. 60 (1971) 1281-1302
3. Fuller C.S., MacRae R.J., Walther M., and Cameron R.E. Interactions in poly(ethylene oxide)-hydroxypropyl methylcellulose blends. Polymer 52 (2001) 9583-9592
4. Janssens, S., Novoa de Armas, H., Roberts, C.J., Van den Mooter, G., in press. Characterization of ternary solid dispersions of itraconazole, PEG 6000 and HPMC 2910 E5, J. Pharm. Sci.
5. Lei Y.G., Cheung Z.L., Ng K.M., Li L., Weng L.T., and Chan C.M. Surface chemical and morphological properties of a blend containing semi-crystalline and amorphous polymers studied with ToF-SIMS, XPS and AFM. Polymer 44 (2003) 3883-3890
6. Leuner C., and Dressman J.B. Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm. Biopharm. 50 (2000) 47-60
7. Matsumoto T., and Zografi G. Physical properties of solid molecular dispersions of indomethacine with PVP and PVPVA in relation to indomethacine recrystallization. Pharm. Res. 16 (1999) 1722-1728
8. Noyes A.A., and Whitney W.R. The rate of dissolution of solid substances in their own solutions. J. Am. Chem. Soc. 19 (1897) 930-934
9. Peeters J., Neeskens P., Tollenaere J.P., Van Remoortere P., and Brewster M.E. Characterization of the interaction of 2-hydroxypropyl-β-cyclodextrin with itraconazole at pH 2, 4 and 7. J. Pharm. Sci. 91 (2002) 1414-1422
10. Schachter D.M., Xiong J., and Tirol G.C. Solid state NMR perspective of drug-polymer solid solutions: a model system based on poly(ethylene oxide). Int. J. Pharm. 281 (2004) 89-101
11. Six K., Leuner C., Dressman J.B., Verreck G., Peeters J., Blaton N., Augustijns P., Kinget R., and Van den Mooter G. Thermal properties of hot-stage extrudates of itraconazole and Eudragit E100, phase separation and polymorphism. J. Therm. Anal. Calorim. 68 (2002) 591-601
12. Six K., Berghmans H., Leuner C., Dressman J., Van Werde K., Mullens J., Benoist L., Thimon M., Meublat L., Verreck G., Peeters J., Brewster M., and Van den Mooter G. Characterization of solid dispersions of itraconazole and hydroxypropylmethylcellulose prepared by melt extrusion. Part II. Pharm. Res. 20 (2003) 1047-1054
13. Six K., Verreck G., Peeters J., Brewster M., and Van den Mooter G. Increased physical stability and improved dissolution properties of itraconazole, a class II drug, by solid dispersions that combine fast and slow dissolving polymers. J. Pharm. Sci. 93 (2004) 124-131
14. Weuts I., Kempen D., Decorte A., Verreck G., Peeters J., Brewster M., and Van den Mooter G. Physical stability of the amorphous state of loperamide and two fragment molecules in solid dispersions with the polymers PVP-K30 and PVP-VA64. Eur. J. Pharm. Sci. 25 (2005) 313-320