Bioreductive drugs: Selectivity towards hypoxic tissue

Expert Opinion on Therapeutic Patents

Volumn 9, Issue 10, 1999, Pages 1371-1380

  Jaffar, M ^a   Stratford, I J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Bioreductive drugs; Delivery agents; Gene directed enzyme prodrug therapy (GDEPT); Hypoxia; Hypoxia selective; Hypoxic markers; Indolequinones; Ischaemia; N oxides; Nitroaniline; Nitroaromatics; Nitroimidazole; Nitromethyl quaternary salts; Radiosensitisers; Reductive enzymes

Indexed keywords

1 (2 BROMOETHYLAMINO) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 1 AZIRIDINO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 2 (2 NITRO 1 IMIDAZOLYL) N (3,3,3 TRIFLUORO 2 HYDROXYPROPYL)ACETAMIDE; 5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; 5 (1 AZIRIDINYL) 3 HYDROXYMETHYL 2 (3 HYDROXY 1 PROPENYL) 1 METHYL 4,7 INDOLEDIONE; ACETYLSALICYLIC ACID; AROMATIC NITRO COMPOUND; INDOLE DERIVATIVE; MISONIDAZOLE; MITOMYCIN C; NITROIMIDAZOLE; PIMONIDAZOLE; PRODRUG; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCING AGENT; SN 23862; UNCLASSIFIED DRUG;

CLINICAL TRIAL; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; HUMAN; HYPOXIC CELL; NONHUMAN; REDUCTION; REVIEW; SOLID TUMOR; TUMOR CELL;

EID: 0032823966     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.9.10.1371     Document Type: Review

References (56)