Rapid communication: Concentration of enzymatically active prostate-specific antigen (PSA) in the extracellular fluid of primary human prostate cancers and human prostate cancer xenograft models

Prostate

Volumn 48, Issue 1, 2001, Pages 1-6

  Denmeade, Samuel R ^a   Sokoll, Lori J ^b   Chan, Daniel W ^b   Khan, Saeed R ^a   Isaacs, John T ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Extracellular fluid; Prodrug; Prostate cancer; Prostate specific antigen (PSA); Xenograft

Indexed keywords

MONOCLONAL ANTIBODY; PROSTATE SPECIFIC ANTIGEN; COUMARIN DERIVATIVE; HISTIDYL SERYL SERYL LYSYL LEUCYL GLUTAMINYL 7 AMINO 4 METHYLCOUMARIN; HISTIDYL-SERYL-SERYL-LYSYL-LEUCYL-GLUTAMINYL-7-AMINO-4-METHYLCOUMARIN; OLIGOPEPTIDE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN DETECTION; ARTICLE; CANCER DIAGNOSIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; EXTRACELLULAR FLUID; HUMAN; HUMAN CELL; HYDROLYSIS; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; SERUM; TUMOR XENOGRAFT; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CELL CULTURE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; EXTRACELLULAR SPACE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METABOLISM; MOUSE STRAIN; PATHOLOGY; PROSTATE TUMOR; XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; DISEASE MODELS, ANIMAL; EXTRACELLULAR SPACE; HUMANS; MALE; MICE; MICE, INBRED STRAINS; OLIGOPEPTIDES; PRODRUGS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0035876331     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.1075     Document Type: Article

References (23)

1. Cytotoxic chemotherapy for advanced hormone-resistant prostate cancer
2. Enzymatic activation of prodrugs by prostate specific antigen: Targeted therapy for metastatic prostate cancer
3. Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine protease inhibitors
4. Semenogelin, the predominant protein in human semen
5. The chymotrypsin-like activity of human prostate-specific antigen γ-seminoprotein
6. Specific and efficient peptide substrates for assaying the proteolytic activity of prostate specific antigen
7. Enzymatic-activation of a doxorubicin-peptide prodrug by prostate-specific antigen
8. In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts
9. LNCAP model of human prostatic carcinoma
10. Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID mice
11. Human prostatic adenocarcinoma: Some characteristics of a serially transplantable line in nude mice (PC-82)
12. Production of recombinant PSA and hk2 and analysis of their immunologic cross-reactivity
13. Free and complexed prostate-specific antigen (PSA): Invitro stability, epitope map, and development of immunofluoremetric assays for specific and sensitive detection of free PSA and PSA-α1-anti-chymotrypsin complex
14. The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to androgens
15. Characterization of androgen receptors in a transplantable human prostatic adenocarcinoma (PC-82)
16. Androgen-sensitive human prostate cancer cells, LNCaP, produce both N-terminally mature and truncated prostate-specific antigen isoforms
17. Characterization and processing of prostate-specific antigen (hK3) and human glandular kallikrein 2 (hK2) secreted by LNCaP cells
18. Different proportions of various prostate-specific antigen (PSA) and human kallikrein 2 (hK2) forms are present in noninduced and androgen-induced LNCaP cells
19. Prostate-specific antigen
20. Expression of pro form of prostate-specific antigen by mammalian cells and its conversion to mature, active form by human kallikrein 2
21. Characterization of the precursor of prostate-specific antigen
22. Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2
23. Expression, purification and characterization of deglycosylated human pro-prostate-specific antigen