A house with many rooms: How the heart got its chambers with foxn4

Genes and Development

Volumn 22, Issue 6, 2008, Pages 706-710

  Cohen, Ethan David ^a   Morrisey, Edward E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MUTANT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXN4; TRANSCRIPTION FACTOR TBX2B; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG;

ATRIOVENTRICULAR CANAL; CELL DIFFERENTIATION; CELL MATURATION; CORONARY ARTERY BLOOD FLOW; FOX GENE; GENE EXPRESSION; GENE MUTATION; GENE REARRANGEMENT; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HEART ATRIUM; HEART DEVELOPMENT; HEART FUNCTION; HEART RHYTHM; HEART VENTRICLE; HUMAN; MORPHOGENESIS; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; ZEBRA FISH;

ANIMALS; ATRIOVENTRICULAR NODE; FORKHEAD TRANSCRIPTION FACTORS; HEART; T-BOX DOMAIN PROTEINS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 41149147697     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1662408     Document Type: Review

References (21)

1. Basson, C.T., Bachinsky, D.R., Lin, R.C., Levi, T., Elkins, J.A., Soults, J., Grayzel, D., Kroumpouzou, E., Traill, T.A., Leblanc-Straceski, J., et al. 1997. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat. Genet. 15: 30-35.
2. Bruneau, B.G., Nemer, G., Schmitt, J.P., Charron, F., Robitaille, L., Caron, S., Conner, D.A., Gessler, M., Nemer, M., Seidman, C.E., et al. 2001. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-721.
3. Cai, C.L., Zhou, W., Yang, L., Bu, L., Qyang, Y., Zhang, X., Li, X., Rosenfeld, M.G., Chen, J., and Evans, S. 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132: 2475-2487.
4. Chi, N.C., Shaw, R.M., De Val, S., Kang, G., Jan, L.Y., Black, B.L., and Stainier, D.Y.R. 2008. Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes & Dev. (this issue), doi: 10.1101/gad.1629408.
5. Christoffels, V.M., Hoogaars, W.M., Tessari, A., Clout, D.E., Moorman, A.F., and Campione, M. 2004. T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229: 763-770.
6. Gurvitz, M. and Stout, K. 2007. Ebstein's anomaly of the tricuspid valve. Curr. Cardiol. Rep. 9: 336-342.
7. Habets, P.E., Moorman, A.F., Clout, D.E., van Roon, M.A., Lingbeek, M., van Lohuizen, M., Campione, M., and Christoffels, V.M. 2002. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: Implications for cardiac chamber formation. Genes & Dev. 16: 1234-1246.
8. Harrelson, Z., Kelly, R.G., Goldin, S.N., Gibson-Brown, J.J., Bollag, R.J., Silver, L.M., and Papaioannou, V.E. 2004. Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 131: 5041-5052.
9. Hiroi, Y., Kudoh, S., Monzen, K., Ikeda, Y., Yazaki, Y., Nagai, R., and Komuro, I. 2001. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat. Genet. 28: 276-280.
10. Kaestner, K.H., Knochel, W., and Martinez, D.E. 2000. Unified nomenclature for the winged helix/forkhead transcription factors. Genes & Dev. 14: 142-146.
11. Kelly, R.G. and Buckingham, M.E. 2002. The anterior heart-forming field: Voyage to the arterial pole of the heart. Trends Genet. 18: 210-216.
12. Lehmann, O.J., Sowden, J.C., Carlsson, P., Jordan, T., and Bhattacharya, S.S. 2003. Fox's in development and disease. Trends Genet. 19: 339-344.
13. Miskolczi-McCallum, C.M., Scavetta, R.J., Svendsen, P.C., Soanes, K.H., and Brook, W.J. 2005. The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. Dev. Biol. 278: 459-472.
14. Paranon, S. and Acar, P. 2008. Ebstein's anomaly of the tricuspid valve: From fetus to adult: Congenital heart disease. Heart 94: 237-243.
15. Qian, L., Liu, J., and Bodmer, R. 2005. Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart. Dev. Biol. 279: 509-524.
16. Reim, I., Mohler, J.P., and Frasch, M. 2005. Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila. Mech. Dev. 122: 1056-1069.
17. Seo, S. and Kume, T. 2006. Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev. Biol. 296: 421-436.
18. Shu, W., Yang, H., Zhang, L., Lu, M.M., and Morrisey, E.E. 2001. Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J. Biol. Chem. 276: 27488-27497.
19. Wang, B., Weidenfeld, J., Lu, M.M., Maika, S., Kuziel, W.A., Morrisey, E.E., and Tucker, P.W. 2004. Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development 131: 4477-4487.
20. Washington Smoak, I., Byrd, N.A., Abu-Issa, R., Goddeeris, M.M., Anderson, R., Morris, J., Yamamura, K., Klingensmith, J., and Meyers, E.N. 2005. Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. Dev. Biol. 283: 357-372.
21. Yamagishi, H., Maeda, J., Hu, T., McAnally, J., Conway, S.J., Kume, T., Meyers, E.N., Yamagishi, C., and Srivastava, D. 2003. Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes & Dev. 17: 269-281.