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Volumn 8, Issue 1, 2008, Pages 13-18

Current stem cell technology: Limitations and realistic expectations

Author keywords

Medical biotechnology; Regenerative medicine; Stem cells

Indexed keywords

CELLS; IMMUNOLOGY; MEDICINE; PATHOLOGY; TISSUE;

EID: 41149140422     PISSN: 16180240     EISSN: 16182863     Source Type: Journal    
DOI: 10.1002/elsc.200820226     Document Type: Review
Times cited : (5)

References (53)
  • 1
    • 0021333676 scopus 로고
    • Characterization of a pluripotent stem cell line derived from a mouse embryo
    • A. M. Wobus, H. Holzhausen, P. Jäkel, J. Schöneich, Characterization of a pluripotent stem cell line derived from a mouse embryo, Exp. Cell Res. 1984, 152, 212-219.
    • (1984) Exp. Cell Res , vol.152 , pp. 212-219
    • Wobus, A.M.1    Holzhausen, H.2    Jäkel, P.3    Schöneich, J.4
  • 3
    • 33750220712 scopus 로고    scopus 로고
    • Bridging the regeneration gap: Genetic insights from diverse animal models
    • A. S. Alvarado, P. A. Tsonis, Bridging the regeneration gap: genetic insights from diverse animal models, Nature Rev. Genetics 2006, 7, 873-884.
    • (2006) Nature Rev. Genetics , vol.7 , pp. 873-884
    • Alvarado, A.S.1    Tsonis, P.A.2
  • 4
    • 0035424116 scopus 로고    scopus 로고
    • In vivo imaging indicates muscle fiber dedifferentiation is a major contributor to the regenerating tail blastema
    • K. Echeverri, J. D. Clarke, E. M. Tanaka, In vivo imaging indicates muscle fiber dedifferentiation is a major contributor to the regenerating tail blastema, Dev. Biol. 2001, 236, 151-164.
    • (2001) Dev. Biol , vol.236 , pp. 151-164
    • Echeverri, K.1    Clarke, J.D.2    Tanaka, E.M.3
  • 5
    • 0037032827 scopus 로고    scopus 로고
    • Ectoderm to mesoderm lineage switching during axolotl tail regeneration
    • K. Echeverri, E. M. Tanaka, Ectoderm to mesoderm lineage switching during axolotl tail regeneration, Science 2002, 298, 1993-1996.
    • (2002) Science , vol.298 , pp. 1993-1996
    • Echeverri, K.1    Tanaka, E.M.2
  • 6
    • 38349023585 scopus 로고    scopus 로고
    • Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate
    • A. Kumar, J. W. Godwin, P. B. Gates, A. A. Garza-Garcia, J. P. Brockes, Molecular basis for the nerve dependence of limb regeneration in an adult vertebrate, Science 2007, 318 (5851), 772-777.
    • (2007) Science , vol.318 , Issue.5851 , pp. 772-777
    • Kumar, A.1    Godwin, J.W.2    Gates, P.B.3    Garza-Garcia, A.A.4    Brockes, J.P.5
  • 7
    • 0037213612 scopus 로고    scopus 로고
    • Transdifferentiation of pancreas to liver
    • C. N. Shen, M. E. Horb, J. M. Slack, D. Tosh, Transdifferentiation of pancreas to liver, Mech. Dev. 2003, 120, 107-116.
    • (2003) Mech. Dev , vol.120 , pp. 107-116
    • Shen, C.N.1    Horb, M.E.2    Slack, J.M.3    Tosh, D.4
  • 8
    • 0037213235 scopus 로고    scopus 로고
    • Pancreatic-hepatic switches in vivo
    • M. Grompe, Pancreatic-hepatic switches in vivo, Mech. Dev. 2003, 120, 99-106.
    • (2003) Mech. Dev , vol.120 , pp. 99-106
    • Grompe, M.1
  • 10
    • 24944441782 scopus 로고    scopus 로고
    • Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates
    • A. L. Means, I. M. Meszoely, K. Suzuki, Y. Miyamoto, A. K. Rustgi, R. J. Jr. Coffey et al., Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates, Development 2005, 132, 3767-3776.
    • (2005) Development , vol.132 , pp. 3767-3776
    • Means, A.L.1    Meszoely, I.M.2    Suzuki, K.3    Miyamoto, Y.4    Rustgi, A.K.5    Coffey Jr., R.J.6
  • 11
    • 0029585231 scopus 로고    scopus 로고
    • A. Patapoutian, B. J. Wold, R. A Wagner, Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle, Science 1995, 270, 1818-1821.
    • A. Patapoutian, B. J. Wold, R. A Wagner, Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle, Science 1995, 270, 1818-1821.
  • 12
    • 0001007689 scopus 로고
    • Introduction: Transdifferentiation
    • G. Eguchi, Introduction: transdifferentiation, Semin. Cell Biol. 1995, 6, 105-108.
    • (1995) Semin. Cell Biol , vol.6 , pp. 105-108
    • Eguchi, G.1
  • 13
    • 0035479834 scopus 로고    scopus 로고
    • Transdifferentiation and metaplasia-switching cell types
    • J. M. W. Slack, D. Tosh, Transdifferentiation and metaplasia-switching cell types, Curt. Opin. Genet. Dev. 2001, 11, 581-586.
    • (2001) Curt. Opin. Genet. Dev , vol.11 , pp. 581-586
    • Slack, J.M.W.1    Tosh, D.2
  • 16
    • 1642269178 scopus 로고    scopus 로고
    • In vivo differentiation potential of tracheal basal cells: Evidence for multipotent and unipotent subpopulations
    • K. U. Hong, S. D. Reynolds, S. Watkins, E. Fuchs, B. R. Stripp, In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations, Am. J. Physiol. Lung Cell Mol. Physiol. 2004, 286, L643-649.
    • (2004) Am. J. Physiol. Lung Cell Mol. Physiol , vol.286
    • Hong, K.U.1    Reynolds, S.D.2    Watkins, S.3    Fuchs, E.4    Stripp, B.R.5
  • 17
    • 33749186808 scopus 로고    scopus 로고
    • Hepatic stem cells: In search of
    • M. H. Walkup, D. A. Gerber, Hepatic stem cells: in search of, Stem Cells 2006, 24, 1833-1840.
    • (2006) Stem Cells , vol.24 , pp. 1833-1840
    • Walkup, M.H.1    Gerber, D.A.2
  • 18
    • 17244366379 scopus 로고    scopus 로고
    • Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons
    • Y. Amoh, L. Li, K. Katsuoka, S. Penman, R. M. Hoffman, Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons, Proc. Natl. Acad. Sci. USA 2005, 102, 5530-5534.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5530-5534
    • Amoh, Y.1    Li, L.2    Katsuoka, K.3    Penman, S.4    Hoffman, R.M.5
  • 19
    • 28444491801 scopus 로고    scopus 로고
    • Clonal analysis of the differentiation potential of human adipose-derived adult stem cells
    • F. Guilak, K. E. Lott, H. A. Awad, Q. Cao, K. C. Hicok, B. Fermor, Clonal analysis of the differentiation potential of human adipose-derived adult stem cells, J. Cell Physiol. 2006, 206, 229-237.
    • (2006) J. Cell Physiol , vol.206 , pp. 229-237
    • Guilak, F.1    Lott, K.E.2    Awad, H.A.3    Cao, Q.4    Hicok, K.C.5    Fermor, B.6
  • 21
    • 3242755834 scopus 로고    scopus 로고
    • A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential
    • G. Kogler, S. Sensken, J. A. Airey, T. Trapp, M. Muschen, N. Feldhahn et al., A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential, J. Exp. Med. 2004, 200, 123-135.
    • (2004) J. Exp. Med , vol.200 , pp. 123-135
    • Kogler, G.1    Sensken, S.2    Airey, J.A.3    Trapp, T.4    Muschen, M.5    Feldhahn, N.6
  • 22
    • 3843085863 scopus 로고    scopus 로고
    • Pluripotent neural crest stem cells in the adult hair follicle
    • M. Sieber-Blum, M. Grim, Y. F. Hu, V. Szeder, Pluripotent neural crest stem cells in the adult hair follicle, Dev. Dyn. 2004, 231, 258-269.
    • (2004) Dev. Dyn , vol.231 , pp. 258-269
    • Sieber-Blum, M.1    Grim, M.2    Hu, Y.F.3    Szeder, V.4
  • 23
    • 33646336640 scopus 로고    scopus 로고
    • Pluripotency of spermatogonial stem cells from adult mouse testis
    • K. Guan, K. Nayernia, L. S. Maier, S. Wagner, R. Dressel, J. H. Lee et al., Pluripotency of spermatogonial stem cells from adult mouse testis, Nature 2006, 440, 1199-1203.
    • (2006) Nature , vol.440 , pp. 1199-1203
    • Guan, K.1    Nayernia, K.2    Maier, L.S.3    Wagner, S.4    Dressel, R.5    Lee, J.H.6
  • 24
    • 33750209164 scopus 로고    scopus 로고
    • Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures
    • C. Kruse, J. Kajahn, A. E. Petschnik, A. Maaß, E. Klink, D. H. Rapoport et al., Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures, Ann. Anat. 2006, 188, 503-517.
    • (2006) Ann. Anat , vol.188 , pp. 503-517
    • Kruse, C.1    Kajahn, J.2    Petschnik, A.E.3    Maaß, A.4    Klink, E.5    Rapoport, D.H.6
  • 25
    • 0030891163 scopus 로고    scopus 로고
    • Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice
    • M. A. Eglitis, E. Mezey, Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice, Proc. Natl. Acad. Sci. USA 1997, 94, 4080-4085.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4080-4085
    • Eglitis, M.A.1    Mezey, E.2
  • 26
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • M. J. Evans, M. H. Kaufman, Establishment in culture of pluripotential cells from mouse embryos, Nature 1981, 292, 154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 27
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • G. R. Martin, Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells, Proc. Natl. Acad. Sci. USA 1981, 78, 7634-7638.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 29
    • 3242668097 scopus 로고    scopus 로고
    • The role of stem cell transplantation in chronic lymphocytic leukemia
    • V. Rizouli, J. G. Gribben, The role of stem cell transplantation in chronic lymphocytic leukemia, Semin. Hematol. 2004, 41, 246-253.
    • (2004) Semin. Hematol , vol.41 , pp. 246-253
    • Rizouli, V.1    Gribben, J.G.2
  • 30
    • 4444227593 scopus 로고    scopus 로고
    • Stem cell transplantation for chronic lymphocytic leukemia: Should not more patients get a transplant?
    • E. Jabbour, M. J. Keating, R. E. Champlin, I. F. Khouri, Stem cell transplantation for chronic lymphocytic leukemia: Should not more patients get a transplant?, Bone Marrow Transplant. 2004, 34, 289-297.
    • (2004) Bone Marrow Transplant , vol.34 , pp. 289-297
    • Jabbour, E.1    Keating, M.J.2    Champlin, R.E.3    Khouri, I.F.4
  • 31
    • 0141426822 scopus 로고    scopus 로고
    • SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus
    • R. K. Burt, A. E. Traynor, SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus, Arthritis Res. Ther. 2003, 5, 207-209.
    • (2003) Arthritis Res. Ther , vol.5 , pp. 207-209
    • Burt, R.K.1    Traynor, A.E.2
  • 32
    • 33845483348 scopus 로고    scopus 로고
    • J. Sibilia, Treatment of systemic lupus erythematosus in 2006, Joint Bone Spine 2006, 73, 591-598.
    • J. Sibilia, Treatment of systemic lupus erythematosus in 2006, Joint Bone Spine 2006, 73, 591-598.
  • 33
    • 33749646189 scopus 로고    scopus 로고
    • Adult stem cells in the treatment of autoimmune diseases
    • J. M. van Laar, A. Tyndall, Adult stem cells in the treatment of autoimmune diseases, Rheumatology 2006, 45, 1187-1193.
    • (2006) Rheumatology , vol.45 , pp. 1187-1193
    • van Laar, J.M.1    Tyndall, A.2
  • 34
    • 33947143592 scopus 로고    scopus 로고
    • Mobilization, harvesting and selection of peripheral blood stem cells in patients with autoimmune diseases undergoing autologous hematopoietic stem cell transplantation
    • L. Statkute, L. Verda, Y. Oyama, A. Traynor, M. Villa, T. Shook et al., Mobilization, harvesting and selection of peripheral blood stem cells in patients with autoimmune diseases undergoing autologous hematopoietic stem cell transplantation, Bone Marrow Transplant. 2007, 39, 317-329.
    • (2007) Bone Marrow Transplant , vol.39 , pp. 317-329
    • Statkute, L.1    Verda, L.2    Oyama, Y.3    Traynor, A.4    Villa, M.5    Shook, T.6
  • 35
    • 0035964391 scopus 로고    scopus 로고
    • Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines
    • H. Kamihata, H. Matsubara, T. Nishiue, S. Fujiyama, Y. Tsutsumi, R. Ozono et al., Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines, Circulation 2001, 104, 1046-1052.
    • (2001) Circulation , vol.104 , pp. 1046-1052
    • Kamihata, H.1    Matsubara, H.2    Nishiue, T.3    Fujiyama, S.4    Tsutsumi, Y.5    Ozono, R.6
  • 36
    • 0037044406 scopus 로고    scopus 로고
    • Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    • B. E. Strauer, M. Brehm, T. Zeus, M. Kostering, A. Hernandez, R. V. Sorg et al., Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans, Circulation 2002, 106, 1913-1918.
    • (2002) Circulation , vol.106 , pp. 1913-1918
    • Strauer, B.E.1    Brehm, M.2    Zeus, T.3    Kostering, M.4    Hernandez, A.5    Sorg, R.V.6
  • 37
    • 34250354766 scopus 로고    scopus 로고
    • Intracoronary autologous bone marrow cell transplantation beneficially modulates heart rate variability
    • P. O. Schueller, C. Meyer, M. Brehm, P. Wernet, C. M. Schannwell, B.E. Strauer, Intracoronary autologous bone marrow cell transplantation beneficially modulates heart rate variability, Int. J. Cardiol. 2006, 119 (3), 398-399.
    • (2006) Int. J. Cardiol , vol.119 , Issue.3 , pp. 398-399
    • Schueller, P.O.1    Meyer, C.2    Brehm, M.3    Wernet, P.4    Schannwell, C.M.5    Strauer, B.E.6
  • 38
    • 33745206550 scopus 로고    scopus 로고
    • Stem cell therapy for ischemic heart disease: Beginning or end of the road?
    • C. Stamm, A. Liebold, G. Steinhoff, D. Strunk, Stem cell therapy for ischemic heart disease: beginning or end of the road?, Cell Transplant 2006, 15, 147-156.
    • (2006) Cell Transplant , vol.15 , pp. 147-156
    • Stamm, C.1    Liebold, A.2    Steinhoff, G.3    Strunk, D.4
  • 39
    • 19544386310 scopus 로고    scopus 로고
    • Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells
    • T. Fujikawa, S. H. Oh, L. Pi, H. M. Hatch, T. Shupe, B. E. Petersen, Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells, Am. J. Pathol. 2005, 166, 1781-1791.
    • (2005) Am. J. Pathol , vol.166 , pp. 1781-1791
    • Fujikawa, T.1    Oh, S.H.2    Pi, L.3    Hatch, H.M.4    Shupe, T.5    Petersen, B.E.6
  • 40
    • 33646574938 scopus 로고    scopus 로고
    • Growth of teratomas derived from human pluripotent stem cells is influenced by the graft site
    • M. J. Cooke, M. Stojkovic, S. A. Przyborski, Growth of teratomas derived from human pluripotent stem cells is influenced by the graft site, Stem Cells Dev. 2006, 15, 254-259.
    • (2006) Stem Cells Dev , vol.15 , pp. 254-259
    • Cooke, M.J.1    Stojkovic, M.2    Przyborski, S.A.3
  • 41
    • 33745542454 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: Effect of in vitro differentiation on graft survival and teratoma formation
    • A. Brederlau, A. S. Correia, S.V. Anisimov, M. Elmi, G. Paul, L. Roybon et al., Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation, Stem Cells 2006, 24, 1433-1440.
    • (2006) Stem Cells , vol.24 , pp. 1433-1440
    • Brederlau, A.1    Correia, A.S.2    Anisimov, S.V.3    Elmi, M.4    Paul, G.5    Roybon, L.6
  • 42
    • 1642578983 scopus 로고    scopus 로고
    • Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells
    • Y. Matsuzaki, K. Kinjo, R. C. Mulligan, H. Okano, Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells, Immunity 2004, 20, 87-93.
    • (2004) Immunity , vol.20 , pp. 87-93
    • Matsuzaki, Y.1    Kinjo, K.2    Mulligan, R.C.3    Okano, H.4
  • 44
    • 33750212354 scopus 로고    scopus 로고
    • Stem cell homing
    • J. P. Chute, Stem cell homing, Curr. Opin. Hematol. 2006, 13, 399-406.
    • (2006) Curr. Opin. Hematol , vol.13 , pp. 399-406
    • Chute, J.P.1
  • 45
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell 2007, 131, 1-12.
    • (2007) Cell , vol.131 , pp. 1-12
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6
  • 46
  • 47
    • 0033815611 scopus 로고    scopus 로고
    • Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: Further evidence for pluripotent pancreatic stem cells in humans
    • V. Gmyr, J. Kerr-Conte, S. Belaich, B. Vandewalle, E. Leteurtre, M. C. Vantyghem, Adult human cytokeratin 19-positive cells reexpress insulin promoter factor 1 in vitro: further evidence for pluripotent pancreatic stem cells in humans, Diabetes 2000, 49, 1671-1680.
    • (2000) Diabetes , vol.49 , pp. 1671-1680
    • Gmyr, V.1    Kerr-Conte, J.2    Belaich, S.3    Vandewalle, B.4    Leteurtre, E.5    Vantyghem, M.C.6
  • 48
    • 4444320484 scopus 로고    scopus 로고
    • Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
    • R. M. Seaberg, S. R. Smukler, T. J. Kieffer, G. Enikolopov, Z. Asghar, M. B. Wheeler, Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages, Nat. Biotechnol. 2004, 22, 1115-1124
    • (2004) Nat. Biotechnol , vol.22 , pp. 1115-1124
    • Seaberg, R.M.1    Smukler, S.R.2    Kieffer, T.J.3    Enikolopov, G.4    Asghar, Z.5    Wheeler, M.B.6
  • 49
    • 8644277274 scopus 로고    scopus 로고
    • Adult pancreas generates multipotent stem cells and pancreatic and nonpancreatic progeny
    • Y. Choi, M. Ta, F. Atouf, N. Lumelsky, Adult pancreas generates multipotent stem cells and pancreatic and nonpancreatic progeny, Stem Cells 2004, 22, 1070-1084.
    • (2004) Stem Cells , vol.22 , pp. 1070-1084
    • Choi, Y.1    Ta, M.2    Atouf, F.3    Lumelsky, N.4
  • 51
    • 33846554384 scopus 로고    scopus 로고
    • Autonomously contracting human cardiomyocytes generated from adult pancreatic stem cells and enhanced in co-cultures with myocardial biopsies
    • Dec. 29
    • N. W. Guldner, J. Kajahn, M. Klinger, H. H. Sievers, C. Kruse, Autonomously contracting human cardiomyocytes generated from adult pancreatic stem cells and enhanced in co-cultures with myocardial biopsies, Int. J. Artif. Organs 2006, Dec. 29 (12), 1158-1166.
    • (2006) Int. J. Artif. Organs , vol.12 , pp. 1158-1166
    • Guldner, N.W.1    Kajahn, J.2    Klinger, M.3    Sievers, H.H.4    Kruse, C.5
  • 52
    • 37049017157 scopus 로고    scopus 로고
    • J. Kajahn, E. Gorjup, S. Tiede, H. von Briesen, R. Paus, C. Kruse et al., Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells, Eur. J. Cell Biol. 2008, 15, 87 (1), 39-46.
    • J. Kajahn, E. Gorjup, S. Tiede, H. von Briesen, R. Paus, C. Kruse et al., Skin-derived human adult stem cells surprisingly share many features with human pancreatic stem cells, Eur. J. Cell Biol. 2008, 15, 87 (1), 39-46.
  • 53
    • 33845620670 scopus 로고    scopus 로고
    • Derivation of oocyte-like cells from a clonal pancreatic stem cell line
    • S. Danner, J. Kajahn, C. Geismann, E. Klink, C. Kruse, Derivation of oocyte-like cells from a clonal pancreatic stem cell line, Mol. Hum. Reprod. 2007, 13, 11-20.
    • (2007) Mol. Hum. Reprod , vol.13 , pp. 11-20
    • Danner, S.1    Kajahn, J.2    Geismann, C.3    Klink, E.4    Kruse, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.