Copper and iron transport across the placenta: Regulation and interactions

Journal of Neuroendocrinology

Volumn 20, Issue 4, 2008, Pages 427-431

  McArdle, Harry J ^a   Andersen, H S ^a   Jones, H ^a   Gambling, L ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Anaemia; Copper; Development; Epithelia; Foetus; Iron

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CALCIUM CHANNEL; CHAPERONE; COPPER; COPPER PROTEIN; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRANSFERRIN RECEPTOR;

ACIDIFICATION; ANEMIA; BASOLATERAL MEMBRANE; CONFERENCE PAPER; COPPER BLOOD LEVEL; COPPER DEFICIENCY; COPPER METABOLISM; CYTOSOL; ENDOCYTOSIS; EVIDENCE BASED MEDICINE; FETOPLACENTAL UNIT; FETUS CIRCULATION; FETUS DEVELOPMENT; FETUS GROWTH; GENETIC REGULATION; HORMONAL REGULATION; HUMAN; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON METABOLISM; IRON TRANSPORT; MATERNAL NUTRITION; MOLECULAR INTERACTION; NONHUMAN; NUTRITIONAL REQUIREMENT; PLACENTAL TRANSFER; PREGNANCY; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALS; COPPER; FEMALE; HUMANS; ION TRANSPORT; IRON; MODELS, BIOLOGICAL; PLACENTA; PREGNANCY;

EID: 41149120285     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2008.01658.x     Document Type: Conference Paper

References (45)

1. Prohaska JR., Gybina AA. Intracellular copper transport in mammals. J Nutr 2004; 134: 1003-1006.
2. Danks DM. Copper deficiency in humans. Annu Rev Nutr 1988; 8: 235-257.
3. Fosset C, McGaw B, Abramovich D, McArdle HJ. Inter-relations between ceruloplasmin and Fe status during pregnancy. Biol Trace Elem Res 2004; 98: 1-12.
4. Beard J, Ungar EL, Bianco LE, Paul T, Rundle SE, Jones BC. Early postnatal iron repletion overcomes lasting effects of gestation iron deficiency in rats. J Nutr 2007; 137: 1176-1182.
5. Lozoff B, Wolf AW, Jimenez E. Iron-deficiency anemia and infant development: Effects of extended oral iron therapy. J Pediatr 1996; 129: 382-389.
6. Zimmerman MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007; 370: 511-520.
7. Godfrey KM, Barker DJ. Maternal nutrition in relation to fetal and placental growth. Eur J Obstet Gynecol Reprod Biol 1995; 61: 15-22.
8. Godfrey KM, Redman CW, Barker DJ, Osmond C. The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight. Br J Obstet Gynaecol 1991; 98: 886-891.
9. Arredondo M, Nunez MT. Iron and copper metabolism. Mol Aspects Med 2005; 26: 313-327.
10. Institute of Medicine. Dietary Reference Intakes for Vitamins and Micronutrients. A Report of the Panel for Micronutrients. Food and Nutrition Board. Institute of Medicine. Washington, DC: National Academy Press, 2001.
11. Henderson L, Irving K, Gregory J, Bates C, Prentice A, Perks J, Swan G, Farron M. Vitamin and Mineral intake and urinary analytes. The National Diet & Nutrition Survey: Adults Aged 19 to 64 Years. London: HMSO, 2004.
12. Waddell J, Steenbock H, Elvehjem C, Hart E. Iron in nutrition V. Iron salts and iron containing ash extracts in the correction of anemia. J Biol Chem 1927; 77: 777-795.
13. Gambling L, McArdle HJ. Iron, copper and fetal development. Proc Nutr Soc 2004; 63: 553-562.
14. Srai SK, Bomford A, McArdle HJ. Iron transport across cell membranes: molecular understanding of duodenal and placental iron uptake. Best Pract Res Clin Haematol 2002; 15: 243-259.
15. McArdle HJ, Douglas AJ, Morgan EH. Transferrin binding by microvillar vesicles isolated from rat placenta. Placenta 1984; 5: 131-138.
16. McArdle HJ, Douglas AJ, Morgan EH. Uptake of transferrin and iron by cultured rat placental cells. J Cell Physiol 1985; 122: 405-409.
17. Gruper Y, Bar J, Bacharach E, Ehrlich R. Transferrin receptor co-localizes and interacts with the hemochromatosis factor (HFE) and the divalent metal transport-1 (DMT1) in trophoblast cells. J Cell Physiol 2005; 204: 901-912.
18. Gunshin H, Fujiwara Y, Custodio AO, DriRenzi C, Robine S, Andrews NC. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensible in placenta and liver. J Clin Invest 2005; 115: 1258-1266.
19. Deicher R, Horl WH. New insights into the regulation of iron homeostasis. Eur J Clin Invest 2006; 36: 301-309.
20. Latunde-Dada GO, Van der Westhuizen J, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT. Molecular and functional roles of duodenal Cytochrome B (Dcytb) in iron metabolism. Blood Cells Mol Dis 2002; 29: 356-360.
21. Chen H, Su T, Attieh ZK, Fox TC, McKie AT, Anderson GJ, Vulpe CD. Systemic regulation of Hephaestin and IREG1 revealed in studies of genetic and nutritional iron deficiency. Blood 2003; 102: 1893-1899.
22. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, Miret S, Bomford A, Peters TJ, Farzaneh F, Hediger MA, Hentze MW, Simpson RJ. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 2000; 5: 299-309.
23. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000; 403: 776-781.
24. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, Gitschier J, Anderson GJ. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999; 21: 195-199.
25. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalisation. Science 2004; 306: 2090-2093.
26. Millard KN, Frazer DM, Wilkins SJ, Anderson GJ. Changes in the expression of intestinal iron transport and hepatic regulatory molecules explain the enhanced iron absorption associated with pregnancy in the rat. Gut 2004; 53: 655-660.
27. Parkkila S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, Fleming RE, Sly WS. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA 1997; 94: 13198-13202.
28. Gambling L, Charania Z, Hannah L, Antipatis C, Lea RG, McArdle HJ. Effect of iron deficiency on placental cytokine expression and fetal growth in the pregnant rat. Biol Reprod 2002; 66: 516-523.
29. Gambling L, Danzeisen R, Gair S, Lea RG, Charania Z, Solanky N, Joory KD, Srai SKS, McArdle HJ. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem J 2001; 356: 883-889.
30. McArdle HJ, Erlich R. Copper uptake and transfer to the mouse fetus during pregnancy. J Nutr 1991; 121: 208-214.
31. Lee J, Prohaska JR, Thiele DJ. Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. PNAS 2001; 98: 6842-6847.
32. Hardman B, Manuelpillai U, Wallace EM, van de Waasenburg S, Cater M, Mercer JF, Ackland ML. Expression and localization of Menkes and Wilson copper transporting ATPases in human placenta. Placenta 2004; 25: 512-517.
33. Bingham MJ, Ong TJ, Ingledew WJ, McArdle HJ. ATP-dependent copper transporter, in the Golgi apparatus of rat hepatocytes, transports Cu(II) not Cu(I). Am J Physiol 1996; 271(5 Pt 1): G741-G746.
34. Hardman B, Michalczyk A, Greenough M, Camakaris J, Mercer JF, Ackland ML. Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells. Biochem J 2007; 402: 241-250.
35. Muramatsu Y, Yamada T, Miura M, Sakai T, Suzuki Y, Serikawa T, Tanzi RE, Matsumoto K. Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans cinnamon rats. Gastroenterology 1994; 107: 1189-1192.
36. Gambling L, Danzeisen R, Fosset C, Andersen HS, Dunford S, Srai SKS, McArdle HJ. Iron and copper interactions in development and the effect on pregnancy outcome. J Nutr 2003; 133: 1S-3S.
37. Danzeisen R, Ponnambalam S, Lea RG, Page K, Gambling L, McArdle HJ. The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase. Placenta 2000; 21: 805-812.
38. Danzeisen R, Fosset C, Page K, David S, McArdle HJ. Placental ceruloplasmin homologue is regulated by iron and copper and is implicated in iron metabolism. Am J Physiol Cell Physiol 2002; 282: C472-C478.
39. Hardman B, Manuelpillai U, Wallace EM, Monty JF, Kramer DR, Kuo YM, Mercer JF, Ackland ML. Expression, localisation and hormone regulation of the human copper transporter hCTR1 in placenta and choriocarcinoma Jeg-3 cells. Placenta 2006; 27: 968-977.
40. McArdle HJ. The metabolism of copper during pregnancy - a review. Food Chem 1995; 54: 79-84.
41. Wapnir RA, Gyasi I, Harper RG, Moyse J, Teichberg S. Placental copper transport in the rat. II: Effect of maternal copper deficiency. Placenta 1996; 17: 479-486.
42. Ebesh O, Barone A, Harper RG, Wapnir RA. Combined effect of high-fat diet and copper deficiency during gestation on fetal copper status in the rat. Biol Trace Elem Res 1999; 67: 139-150.
43. Andersen HS, Gambling L, Holtrop G, McArdle HJ. Effect of dietary copper deficiency on iron metabolism in the pregnant rat. Br J Nutr 2007; 97: 239-246.
44. Takahashi Y, Miyajima H, Shirabe S, Nagataki S, Suenaga A, Gitlin JD. Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease. Hum Mol Genet 1996; 5: 81-84.
45. Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci USA 1999; 96: 10812-10817.