Substitution of DNA-contacting amino acids with functional variants in the Gata-1 zinc finger: A structurally and phylogenetically guided mutagenesis

Biochemical and Biophysical Research Communications

Volumn 369, Issue 4, 2008, Pages 1052-1056

  Vonderfecht, Tyson R ^a   Schroyer, Daniel C ^a   Schenck, Brandy L ^a   McDonough, Virginia M ^a   Pikaart, Michael J ^a  

^a HOPE COLLEGE   (United States)

Author keywords

DNA binding domain; Gata; Site directed mutagenesis; Zinc finger

Indexed keywords

CYSTEINE; DNA BINDING PROTEIN; HELIX LOOP HELIX PROTEIN; LEUCINE; METAL; MUTANT PROTEIN; TRANSCRIPTION FACTOR GATA 1; ZINC FINGER PROTEIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIUM; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DNA STRUCTURE; GENETIC CONSERVATION; MOLECULAR RECOGNITION; MUTAGENESIS; PHYLOGENY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN VARIANT; VERTEBRATE; YEAST;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; DNA; GATA1 TRANSCRIPTION FACTOR; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; PHYLOGENY; PROTEIN CONFORMATION; ZINC FINGERS;

VERTEBRATA;

EID: 41149102807     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.136     Document Type: Article

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