The solution structure of the Leu22→Val mutant AREA DNA binding domain complexed with a TGATAG core element defines a role for hydrophobic packing in the determination of specificity

Journal of Molecular Biology

Volumn 277, Issue 3, 1998, Pages 621-634

  Starich, Mary R ^a   Wikström, Mats ^a   Schumacher, Silke ^a   Arst Jr , Herbert N ^b   Gronenborn, Angela M ^a   Clore, G Marius ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b Du Cane Road W12 ONN ^*  (United Kingdom)

Author keywords

AREA; GATA transcription factors; L22V mutant; NMR structure; Zinc finger

Indexed keywords

DNA; DNA BINDING PROTEIN; LEUCINE; OLIGONUCLEOTIDE; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA PACKAGING; DNA SEQUENCE; GEL ELECTROPHORESIS; GENE EXPRESSION; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN;

EID: 0032478541     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1626     Document Type: Article

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