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Volumn 12, Issue 1, 2008, Pages 164-173

Protein prenylation in glucose-induced insulin secretion from the pancreatic islet β cell: A perspective: Perspective

Author keywords

Cdc42; G proteins; Insulin secretion; Islet cell; Protein farnesylation; Protein geranylgeranylation; Protein prenylation; Rac1

Indexed keywords


EID: 41149099658     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2007.00168.x     Document Type: Article
Times cited : (30)

References (43)
  • 1
    • 0023525741 scopus 로고
    • Calcium, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
    • Prentki M, Matschinsky FM. Calcium, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev. 1987 67 : 1185 248.
    • (1987) Physiol Rev. , vol.67 , pp. 1185-1248
    • Prentki, M.1    Matschinsky, F.M.2
  • 2
    • 0029071517 scopus 로고
    • Metabolic coupling factors in pancreatic β-cell signal transduction
    • Newgard CB, McGarry JD. Metabolic coupling factors in pancreatic β-cell signal transduction. Annu Rev Biochem. 1995 64 : 689 719.
    • (1995) Annu Rev Biochem. , vol.64 , pp. 689-719
    • Newgard, C.B.1    McGarry, J.D.2
  • 3
    • 0141504389 scopus 로고    scopus 로고
    • Regulatory roles for small G proteins in the pancreatic beta-cell: Lessons from models of impaired insulin secretion
    • Kowluru A. Regulatory roles for small G proteins in the pancreatic beta-cell: lessons from models of impaired insulin secretion. Am J Physiol Endocrinol Metab. 2003 285 : E669 84.
    • (2003) Am J Physiol Endocrinol Metab. , vol.285
    • Kowluru, A.1
  • 4
    • 0026681065 scopus 로고
    • Selective inhibitors of GTP synthesis impede exocytotic insulin release from intact rat islets
    • Metz SA, Rabaglia ME, Pintar TJ. Selective inhibitors of GTP synthesis impede exocytotic insulin release from intact rat islets. J Biol Chem. 1992 267 : 12517 27.
    • (1992) J Biol Chem. , vol.267 , pp. 12517-12527
    • Metz, S.A.1    Rabaglia, M.E.2    Pintar, T.J.3
  • 5
    • 0027179707 scopus 로고
    • Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5(-triphosphate in rat islets
    • Metz SA, Meredith M, Rabaglia ME, Kowluru A. Small elevations of glucose concentration redirect and amplify the synthesis of guanosine 5(-triphosphate in rat islets. J Clin Invest. 1993 92 : 872 82.
    • (1993) J Clin Invest. , vol.92 , pp. 872-882
    • Metz, S.A.1    Meredith, M.2    Rabaglia, M.E.3    Kowluru, A.4
  • 6
    • 0030056516 scopus 로고    scopus 로고
    • Glucose-and GTP-dependent stimulation of the carboxylmethylation of Cdc42 in rodent and human pancreatic islets and pure β -cells: Evidence for an essential role for GTP-binding proteins in nutrient-induced insulin secretion
    • Kowluru A, Seavey SE, Li G, Sorenson RL, Weinhaus AJ, Nesher R, Rabaglia ME, Vadakekalam J, Metz SA. Glucose-and GTP-dependent stimulation of the carboxylmethylation of Cdc42 in rodent and human pancreatic islets and pure β -cells: evidence for an essential role for GTP-binding proteins in nutrient-induced insulin secretion. J Clin Invest. 1996 98 : 540 55.
    • (1996) J Clin Invest. , vol.98 , pp. 540-555
    • Kowluru, A.1    Seavey, S.E.2    Li, G.3    Sorenson, R.L.4    Weinhaus, A.J.5    Nesher, R.6    Rabaglia, M.E.7    Vadakekalam, J.8    Metz, S.A.9
  • 7
    • 0030721973 scopus 로고    scopus 로고
    • Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose-and calcium-induced insulin secretion from pancreatic β-cells
    • Kowluru A, Li G, Rabaglia ME, Segu VB, Hofmann F, Aktories K, Metz SA. Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose-and calcium-induced insulin secretion from pancreatic β-cells. Biochem Pharmacol. 1997 54 : 1097 108.
    • (1997) Biochem Pharmacol. , vol.54 , pp. 1097-1108
    • Kowluru, A.1    Li, G.2    Rabaglia, M.E.3    Segu, V.B.4    Hofmann, F.5    Aktories, K.6    Metz, S.A.7
  • 8
    • 1942472545 scopus 로고    scopus 로고
    • Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells
    • Li J, Luo R, Kowluru A, Li G. Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells. Am J Physiol Endocrinol Metab. 2004 286 : E818 27.
    • (2004) Am J Physiol Endocrinol Metab. , vol.286
    • Li, J.1    Luo, R.2    Kowluru, A.3    Li, G.4
  • 9
    • 12544259110 scopus 로고    scopus 로고
    • A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis
    • Nevins AK, Thurmond DC. A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis. J Biol Chem. 2004 280 : 1944 52.
    • (2004) J Biol Chem. , vol.280 , pp. 1944-1952
    • Nevins, A.K.1    Thurmond, D.C.2
  • 10
    • 0041887212 scopus 로고    scopus 로고
    • Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion
    • Nevins AK, Thurmond DC. Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretion. Am J Physiol Cell Physiol. 2003 285 : C698 710.
    • (2003) Am J Physiol Cell Physiol. , vol.285
    • Nevins, A.K.1    Thurmond, D.C.2
  • 11
    • 0345687169 scopus 로고    scopus 로고
    • ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate
    • Lawrence JT, Birnbaum MJ. ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci USA. 2003 100 : 13320 5.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 13320-13325
    • Lawrence, J.T.1    Birnbaum, M.J.2
  • 12
    • 0027364367 scopus 로고
    • Modulation of insulin secretion from normal rat islets by inhibitors of the posttranslational modifications of the GTP-binding proteins
    • Metz SA, Rabaglia ME, Stock JB, Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the posttranslational modifications of the GTP-binding proteins. Biochem J. 1993 295 : 31 40.
    • (1993) Biochem J. , vol.295 , pp. 31-40
    • Metz, S.A.1    Rabaglia, M.E.2    Stock, J.B.3    Kowluru, A.4
  • 13
    • 0027535853 scopus 로고
    • Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion from HIT-T15 cells
    • Li G, Regazzi R, Roche E, Wollheim CB. Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion from HIT-T15 cells. Biochem J. 1993 289 : 379 85.
    • (1993) Biochem J. , vol.289 , pp. 379-385
    • Li, G.1    Regazzi, R.2    Roche, E.3    Wollheim, C.B.4
  • 14
    • 0036786434 scopus 로고    scopus 로고
    • Inhibition of glucose-and calcium-induced insulin secretion from βtC3 cells by novel inhibitors of iso-prenylation
    • Amin R, Chen HQ, Tannous M, Gibbs R, Kowluru A. Inhibition of glucose-and calcium-induced insulin secretion from βTC3 cells by novel inhibitors of iso-prenylation. J Pharmacol Exp Ther. 2002 303 : 82 8.
    • (2002) J Pharmacol Exp Ther. , vol.303 , pp. 82-88
    • Amin, R.1    Chen, H.Q.2    Tannous, M.3    Gibbs, R.4    Kowluru, A.5
  • 15
    • 0037199471 scopus 로고    scopus 로고
    • A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release
    • Daniel S, Noda M, Cerione RA, Sharp GW. A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release. Biochemistry. 2002 41 : 9663 71.
    • (2002) Biochemistry. , vol.41 , pp. 9663-9671
    • Daniel, S.1    Noda, M.2    Cerione, R.A.3    Sharp, G.W.4
  • 16
    • 0030065070 scopus 로고    scopus 로고
    • A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells
    • Kowluru A, Seavey SE, Rhodes CJ, Metz SA. A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells. Biochem J. 1996 313 : 97 107.
    • (1996) Biochem J. , vol.313 , pp. 97-107
    • Kowluru, A.1    Seavey, S.E.2    Rhodes, C.J.3    Metz, S.A.4
  • 17
    • 0028023248 scopus 로고
    • Subcellular localization and characterization of gua-nine nucleotide binding proteins in normal rat and human pancreatic islets and transformed β-cells
    • Kowluru A, Rabaglia ME, Muse KE, Metz SA. Subcellular localization and characterization of gua-nine nucleotide binding proteins in normal rat and human pancreatic islets and transformed β-cells. Biochim Biophys Acta. 1994 1222 : 348 59.
    • (1994) Biochim Biophys Acta. , vol.1222 , pp. 348-359
    • Kowluru, A.1    Rabaglia, M.E.2    Muse, K.E.3    Metz, S.A.4
  • 18
    • 0028176165 scopus 로고
    • Stimulation by PGE2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets
    • Kowluru A, Metz SA. Stimulation by PGE2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets. Biochem J. 1994 297 : 399 406.
    • (1994) Biochem J. , vol.297 , pp. 399-406
    • Kowluru, A.1    Metz, S.A.2
  • 19
    • 0141450545 scopus 로고    scopus 로고
    • Mastoparan-induced insulin secretion from insulin-secreting β TC3 and INS-1 cells: Evidence for its regulation by Rho subfamily of G-proteins
    • Amin RH, Chen H-Q, Veluthakal R, Silver RB, Li J, Li G, Kowluru A. Mastoparan-induced insulin secretion from insulin-secreting β TC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G-proteins. Endocrinology. 2003 144 : 4508 18.
    • (2003) Endocrinology. , vol.144 , pp. 4508-4518
    • Amin, R.H.1    Chen, H.-Q.2    Veluthakal, R.3    Silver, R.B.4    Li, J.5    Li, G.6    Kowluru, A.7
  • 20
    • 0031780223 scopus 로고    scopus 로고
    • Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets
    • Straub SG, James RF, Dunne MJ, Sharp GW. Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets. Diabetes. 1998 47 : 1053 7.
    • (1998) Diabetes. , vol.47 , pp. 1053-1057
    • Straub, S.G.1    James, R.F.2    Dunne, M.J.3    Sharp, G.W.4
  • 21
    • 0001491956 scopus 로고    scopus 로고
    • Subcellular distribution and posttranslational modifications of GTP-binding proteins in insulin-secreting cells
    • Kowluru A, Metz SA. Subcellular distribution and posttranslational modifications of GTP-binding proteins in insulin-secreting cells. Method Neurosci. 1996 29 : 298 318.
    • (1996) Method Neurosci. , vol.29 , pp. 298-318
    • Kowluru, A.1    Metz, S.A.2
  • 22
    • 0141646523 scopus 로고    scopus 로고
    • Novel roles for the rho subfamily of GTP-binding proteins in succinate induced insulin secretion from betaTC3 cells: Further evidence in support of the succinate mechanism of insulin release
    • Kowluru A, Chen HQ, Tannous M. Novel roles for the rho subfamily of GTP-binding proteins in succinate induced insulin secretion from betaTC3 cells: further evidence in support of the succinate mechanism of insulin release. Endocr Res. 2003 29 : 363 76.
    • (2003) Endocr Res. , vol.29 , pp. 363-376
    • Kowluru, A.1    Chen, H.Q.2    Tannous, M.3
  • 23
    • 33644695681 scopus 로고    scopus 로고
    • Rho GDP-dissociation inhibitor (GDI) plays a negative modulatory role in glucose-stimulated insulin secretion
    • Kowluru A, Veluthakal R. Rho GDP-dissociation inhibitor (GDI) plays a negative modulatory role in glucose-stimulated insulin secretion. Diabetes. 2005 54 : 3523 9.
    • (2005) Diabetes. , vol.54 , pp. 3523-3529
    • Kowluru, A.1    Veluthakal, R.2
  • 24
    • 0001775586 scopus 로고    scopus 로고
    • GTP-binding proteins in the regulation of pancreatic β-cell function
    • In: LeRoith, D., Taylor, S.I., Olefsky, J.M., editors. Philadelphia: Lippincott Williams & Wilkins. pp.
    • Kowluru A, Robertson RP, Metz SA. GTP-binding proteins in the regulation of pancreatic β-cell function. In : LeRoith D, Taylor SI, Olefsky JM, editors. Diabetes mellitus: a fundamental and clinical text. Philadelphia : Lippincott Williams & Wilkins. 2000. pp. 78 94.
    • (2000) Diabetes Mellitus: A Fundamental and Clinical Text. , pp. 78-94
    • Kowluru, A.1    Robertson, R.P.2    Metz, S.A.3
  • 25
    • 33745831899 scopus 로고    scopus 로고
    • Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic β-cells
    • Nevins AK, Thurmond DC. Caveolin-1 functions as a novel Cdc42 guanine nucleotide dissociation inhibitor in pancreatic β-cells. J Biol Chem. 2006 281 : 18961 72.
    • (2006) J Biol Chem. , vol.281 , pp. 18961-18972
    • Nevins, A.K.1    Thurmond, D.C.2
  • 26
    • 0030868819 scopus 로고    scopus 로고
    • Glucose activates the carboxylmethylation of subunits of trimeric GTP-binding proteins in pancreatic β-cells
    • Kowluru A, Li G, Metz SA. Glucose activates the carboxylmethylation of subunits of trimeric GTP-binding proteins in pancreatic β-cells. J Clin Invest. 1997 100 : 1596 610.
    • (1997) J Clin Invest. , vol.100 , pp. 1596-1610
    • Kowluru, A.1    Li, G.2    Metz, S.A.3
  • 28
    • 0029966304 scopus 로고    scopus 로고
    • Protein prenyltransferases
    • Casey PJ, Seabra MC. Protein prenyltransferases. J Biol Chem. 1996 : 271 5289 92.
    • (1996) J Biol Chem. , vol.271 , pp. 5289-5292
    • Casey, P.J.1    Seabra, M.C.2
  • 30
    • 0025819073 scopus 로고
    • Protein farnesyltransferase and geranylgeranyl transferase share a common alpha subunit
    • Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL. Protein farnesyltransferase and geranylgeranyl transferase share a common alpha subunit. Cell. 1991 65 : 429 34.
    • (1991) Cell. , vol.65 , pp. 429-434
    • Seabra, M.C.1    Reiss, Y.2    Casey, P.J.3    Brown, M.S.4    Goldstein, J.L.5
  • 31
    • 0033392946 scopus 로고    scopus 로고
    • Enzymology and biology of CaaX protein prenylation
    • Fu HW, Casey PJ. Enzymology and biology of CaaX protein prenylation. Rec Prog Horm Res. 1999 54 : 315 42.
    • (1999) Rec Prog Horm Res. , vol.54 , pp. 315-342
    • Fu, H.W.1    Casey, P.J.2
  • 32
    • 0026713293 scopus 로고
    • The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins
    • Regazzi R, Kikuchi A, Taka Y, Wollheim CB. The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins. J Biol Chem. 1992 267 : 17512 9.
    • (1992) J Biol Chem. , vol.267 , pp. 17512-17519
    • Regazzi, R.1    Kikuchi, A.2    Taka, Y.3    Wollheim, C.B.4
  • 33
    • 0029125753 scopus 로고
    • Differential effects of monoter-penes and lovastatin on RAS processing
    • Hohl RJ, Lewis K. Differential effects of monoter-penes and lovastatin on RAS processing. J Biol Chem. 1995 270 : 17508 12.
    • (1995) J Biol Chem. , vol.270 , pp. 17508-17512
    • Hohl, R.J.1    Lewis, K.2
  • 34
    • 0025952954 scopus 로고
    • Selective inhibition of isoprenylation of 21-26 kDa proteins by the anticarcinogen d-limonene and its metabolites
    • Crowell PL, Chang RR, Ren ZB, Elson CE, Gould MN. Selective inhibition of isoprenylation of 21-26 kDa proteins by the anticarcinogen d-limonene and its metabolites. J Biol Chem. 1991 266 : 17679 85.
    • (1991) J Biol Chem. , vol.266 , pp. 17679-17685
    • Crowell, P.L.1    Chang, R.R.2    Ren, Z.B.3    Elson, C.E.4    Gould, M.N.5
  • 35
    • 0031446103 scopus 로고    scopus 로고
    • Monoterpenes in breast cancer chemo-prevention
    • Crowell PL. Monoterpenes in breast cancer chemo-prevention. Breast Cancer Res Treat. 1997 46 : 191 7.
    • (1997) Breast Cancer Res Treat. , vol.46 , pp. 191-197
    • Crowell, P.L.1
  • 36
    • 0035584412 scopus 로고    scopus 로고
    • Positive modulation by Ras of interleukin-1β-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells
    • Tannous M, Amin R, Popoff MR, Fiorentini C, Kowluru A. Positive modulation by Ras of interleukin-1β-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells. Biochem Pharmacol. 2001 62 : 1459 68.
    • (2001) Biochem Pharmacol. , vol.62 , pp. 1459-1468
    • Tannous, M.1    Amin, R.2    Popoff, M.R.3    Fiorentini, C.4    Kowluru, A.5
  • 37
    • 33847042302 scopus 로고    scopus 로고
    • Dominant-negative alpha-subunit of farnesyl-and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated insulin secretion in INS 832/13 cells
    • Veluthakal R, Kaur H, Goalstone M, Kowluru A. Dominant-negative alpha-subunit of farnesyl-and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated insulin secretion in INS 832/13 cells. Diabetes. 2007 56 : 204 10.
    • (2007) Diabetes. , vol.56 , pp. 204-210
    • Veluthakal, R.1    Kaur, H.2    Goalstone, M.3    Kowluru, A.4
  • 38
    • 34248219593 scopus 로고    scopus 로고
    • Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion
    • Wang Z, Oh E, Thurmond DC. Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion. J Biol Chem. 2007 282 : 9536 46.
    • (2007) J Biol Chem. , vol.282 , pp. 9536-9546
    • Wang, Z.1    Oh, E.2    Thurmond, D.C.3
  • 39
    • 0037255392 scopus 로고    scopus 로고
    • Dominant negative α subunit of farnesyl- and geranylgeranyl transferase-I inhibits insulin-induced differentiation of 3T3-L1 pre-adipocytes
    • Solomon CS, Leitner JW, Goalstone ML. Dominant negative α subunit of farnesyl- and geranylgeranyl transferase-I inhibits insulin-induced differentiation of 3T3-L1 pre-adipocytes. Int J Obes Relat Metab Disord. 2003 27 : 40 7.
    • (2003) Int J Obes Relat Metab Disord. , vol.27 , pp. 40-47
    • Solomon, C.S.1    Leitner, J.W.2    Goalstone, M.L.3
  • 40
    • 0036290187 scopus 로고    scopus 로고
    • Dominant negative subunit of FTase inhibits effects of insulin and IGF in MCF-7 cells
    • Solomon CS, Goalstone ML. Dominant negative subunit of FTase inhibits effects of insulin and IGF in MCF-7 cells. Biochem Biophys Res Commun. 2002 291 : 458 65.
    • (2002) Biochem Biophys Res Commun. , vol.291 , pp. 458-465
    • Solomon, C.S.1    Goalstone, M.L.2
  • 41
    • 0033534769 scopus 로고    scopus 로고
    • Effect of insulin on farne-syltransferase gene transcription and mRNA stability
    • Goalstone ML, Draznin B. Effect of insulin on farne-syltransferase gene transcription and mRNA stability. Biochem Biophys Res Commun. 1999 254 : 243 7.
    • (1999) Biochem Biophys Res Commun. , vol.254 , pp. 243-247
    • Goalstone, M.L.1    Draznin, B.2
  • 42
    • 0029985151 scopus 로고    scopus 로고
    • Effect of insulin on farne-syltransferase activity in 3T3-L1 adipocytes
    • Goalstone ML, Draznin B. Effect of insulin on farne-syltransferase activity in 3T3-L1 adipocytes. J Biol Chem. 1996 271 : 27585 9.
    • (1996) J Biol Chem. , vol.271 , pp. 27585-27589
    • Goalstone, M.L.1    Draznin, B.2
  • 43
    • 33947301430 scopus 로고    scopus 로고
    • Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells
    • Mcdonald P, Veluthakal R, Kaur H, Kowluru A. Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells. Am J Physiol Cell Physiol. 2007 292 : C1216 20.
    • (2007) Am J Physiol Cell Physiol. , vol.292
    • McDonald, P.1    Veluthakal, R.2    Kaur, H.3    Kowluru, A.4


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