The genes influencing adiponectin levels also influence risk factors for metabolic syndrome and type 2 diabetes

Human Biology

Volumn 79, Issue 2, 2007, Pages 191-200

  Comuzzie, Anthony G ^a   Tejero, M Elizabeth ^a   Funahashi, Tohru ^b   Martin, Lisa J ^a   Kissebah, Ahmed ^c   Takahashi, Masahiko ^b   Kihara, Shinji ^b   Tanaka, Sachiyo ^b   Rainwater, David L ^a   Matsuzawa, Yuji ^b   Maccluer, Jean W ^a   Blangero, John ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

ACDC (Adipocyte C1Q and Collagen Domain Containing gene); Adiponectin; Cardiovascular disease; Metabolic syndrome; Mexican Americans; Obesity; Pleiotropy; San Antonio Family Heart Study; Type 2 diabetes mellitus

Indexed keywords

ADIPONECTIN; GLUCOSE; LEPTIN; LIPID;

ADULT; ARTICLE; BIVARIATE ANALYSIS; BODY COMPOSITION; BODY WEIGHT; FEMALE; GENETIC RISK; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PLEIOTROPY; PROTEIN BLOOD LEVEL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; RISK FACTOR; UNITED STATES;

EID: 35448938521     PISSN: 00187143     EISSN: None     Source Type: Journal    
DOI: 10.1353/hub.2007.0029     Document Type: Article

References (43)

1. Ahima, R. S., and J. S. Flier. 2000. Adipose tissue as an endocrine organ. Tr. Endocrinol. Metab. 11:327-332.
2. Almasy, L., and J. Blangero. 1998. Multipoint quantitative-trait genetic analysis in general pedigrees. Am. J. Hum. Genet. 62:1198-1211.
3. Arita, Y., S. Kihara, N. Ouchi et al. 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257:79-83.
4. Beltowski, J. 2003. Adiponectin and resistin: New hormones of white adipose tissue. Med. Sci. Monit. 9:RA55-RA61.
5. Berg, A. H., T. P. Combs, X. Du et al. 2001. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7:947-953.
6. Bradley, R. L., K. A. Cleveland, and B. Cheatham. 2001. The adipocyte as a secretory organ: Mechanisms of vesicle transport and secretory pathways. Rec. Prog. Horm. Res. 56:329-358.
7. Butte, N. F., A. G. Comuzzie, G. Cai et al. 2005. Genetic and environmental factors influencing fasting serum adiponectin in Hispanic children. J. Clin. Endocrinol. Metab. 90:4170-4176.
8. Centers for Disease Control and Prevention. 2006. Maps: Diabetes and Gestational Diabetes Trends Among Adults in the United States, Behavioral Risk Factor Surveillance System. Available at http://www.cdc.gov/diabetes/ statistics/maps/index.htm
9. Chiodini, B. D., and C. M. Lewis. 2003. Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q. Arterioscler. Thromb. Vasc. Biol. 23:1863-1868.
10. Chuang, L. M., Y. F. Chiu, W. H. Sheu et al. 2005. Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of Chinese and Japanese origin. J. Clin. Endocrinol. Metab. 89:5772-5778.
11. Cianflone, K. 1997. Acylation stimulating protein and the adipocyte. J. Endocrinol. 155:203-206.
12. Comuzzie, A. G., T. Funahashi, G. Sonnenberg et al. 2001. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J. Clin. Endocrinol. Metab. 86:4321-4325.
13. Esposito, K., A. Pontillo, C. Di Palo et al. 2003. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: A randomized trial. J. Am. Med. Assoc. 289:1799-1804.
14. Flier, J. S. 1995. The adipocyte: Storage depot or node on the energy information superhighway? Cell 80:15-18.
15. Francke, S., M. Manraj, C. Lacquemant et al. 2001. A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum. Mol. Genet. 10:2751-2765.
16. Fruebis, J., T. S. Tsao, S. Javorschi et al. 2001. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. USA 98:2005-2010.
17. Funahashi, T., T. Nakamura, and I. Shimomura. 1999. Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity. Intern. Med. 38:202-206.
18. Havel, P. J. 2004. Update on adipocyte hormones: Regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53(suppl. 1):S143-S151.
19. Hotamisligil, G. S., P. Arner, J. F. Caro et al. 1995. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest. 95(5):2409-2415.
20. Hotamisligil, G. S., R. A. Graves, P. J. Tontonoz et al. 1993. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. J. Biol. Chem. 268:6823-6826.
21. Hotta, K., T. Funahashi, Y. Arita et al. 2000. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 20:1595-1599.
22. Hotta, K., T. Funahashi, N. L. Bodkin et al. 2001. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133.
23. Hu, E., P. Liang, and B. M. Spiegelman. 1996. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271:10,697-10,703.
24. Kissebah, A. H., G. E. Sonnenberg, J. Myklebust et al. 2000. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl. Acad. Sci. USA 97:14,478-14,483.
25. Lindsay, R. S., T. Funahashi, J. Krakoff et al. 2003. Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes 52:2419-2425.
26. Maslowska, M., T. Scantlebury, R. Germinario et al. 1997. Acute in vitro production of acylation stimulating protein in differentiated human adipocytes. J. Lipid Res. 38:1-11.
27. Mohamed-Ali, V., J. H. Pinkney, and S. W. Coppack. 1998. Adipose tissue as an endocrine and paracrine organ. Int. J. Obes. Relat. Metab. Disord. 22:1145-1158.
28. Mokdad, A. H., M. K. Serdula, W. H. Dietz et al. 1999. The spread of the obesity epidemic in the United States, 1991-1998. J. Am. Med. Assoc. 282:1519-1522.
29. Nakamura, Y., K. Shimada, D. Fukuda et al. 2004. Implications of plasma concentrations of adiponectin in patients with coronary artery disease. Heart 90:528-533.
30. Okamoto, Y., Y. Arita, M. Nishida et al. 2000. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm. Metab. Res. 32:47-50.
31. Ouchi, N., S. Kihara, Y. Arita et al. 2000. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappa B signaling through a cAMP-dependent pathway. Circulation 102:1296-1301.
32. Pollin, T. I., K. Tanner, J. R. O'Connell et al. 2005. Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APMI gene. Diabetes 54:268-274.
33. Scherer, P. E., S. Williams, M. Fogliano et al. 1995. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270:26,746-16,749.
34. Self, S. G., and K. Y. Liang. 1997. Asymptotic properties of maximum likelihood ratio test under non-standard conditions. J. Am. Stat. Assoc. 82:605-610.
35. Shimada, K., T. Miyazaki, and H. Daida. 2004. Adiponectin and atherosclerotic disease. Clin. Chim. Acta 344:1-12.
36. Shimomura, I., T. Funahashi, M. Takahashi et al. 1996. Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity. Nat. Med. 2:800-803.
37. Tataranni, P. A., and E. Ortega. 2005. A burning question: Does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes? Diabetes 54:917-927.
38. Tejero, M. E., J. H. Freeland-Graves, J. M. Proffitt et al. 2004. Adiponectin but not resistin is associated with insulin resistance-related phenotypes in baboons. Obes. Res. 12:871-877.
39. Vionnet, N., El-H. Hani, S. Dupont et al. 2000. Genomewide search for type 2 diabetes susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2 diabetes locus on chromosome 1q21-q24. Am. J. Hum. Genet. 67:1470-1480.
40. Weyer, C., J. S. Yudkin, C. D. Stehouwer et al. 2002. Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis 161:233-242.
41. Yamauchi, T., J. Kamon, H. Waki et al. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7:941-946.
42. Yang, W. S., and L. M. Chuang. 2006. Human genetics of adiponectin in the metabolic syndrome. J. Mol. Med. 84:112-121.
43. Zhang, Y., R. Proenca, M. Maffei et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.