Structure-activity relationships of receptor binding of 1,4-dihydropyridine derivatives

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 3, 2008, Pages 473-479

  Takahashi, Daiki ^c   Oyunzul, Luvsandorj ^a   Onoue, Satomi ^a   Ito, Yoshihiko ^a   Uchida, Shinya ^a   Simsek, Rahime ^b   Gunduz, Miyase Gozde ^b   Safak, Chiat ^b   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b HACETTEPE UNIVERSITY   (Turkey)

^c NONE

Author keywords

1,4 dihydropyridine; Hexahydroquinoline derivative; L type calcium channel antagonist receptor; Structure activity relationship

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ALPHA 1 ADRENERGIC RECEPTOR; CALCIUM CHANNEL BLOCKING AGENT; ESTER DERIVATIVE; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR; NIFEDIPINE; PURINERGIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTRON; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BRAIN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; DIHYDROPYRIDINES; KATP CHANNELS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, ADRENERGIC; RECEPTORS, NICOTINIC; RECEPTORS, PURINERGIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41149094441     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.473     Document Type: Article

References (36)

1. Janis R. A., Triggle D. J., J. Med. Chem., 26, 775-785 (1983).
2. Godfraind T., Miller R., Wibo M., Pharmacol. Rev., 38, 321-416 (1986).
3. Frishman W. H., Michaelson M. D., Am. J. Cardiol., 79, 33-38 (1997).
4. Vandergoten P., Benit E., Dendale P., Acta Cardiol., 54, 71-76 (1999).
5. Fujii S., Kameyama K., Hosono M., Hayashi Y., Kitamura K., J. Pharmacol. Exp. Ther., 280, 1184-1191 (1997).
6. Furukawa T., Nukada T., Suzuki K., Fujita Y., Mori Y., Nishimura M., Tamanaka M., Br. J. Pharmacol., 122, 1136-1140 (1997).
7. Uneyama H., Takahara A., Dohmoto H., Yoshimoto R., Inoue K., Akaike N., Br. J. Pharmacol., 122, 37-42 (1997).
8. Masumiya H., Tanaka H., Shigenobu K., Eur. J. Pharmacol., 335, 15-21 (1997).
9. Triggle D. J., Cell. Mol. Neurobiol., 23, 293-303 (2003).
10. Altas Y., Safak C., Batu O. S., Erol K., Arzneim.-Forsch., 49, 824-829 (1999).
11. Kismetli E., Safak C., Erol K., Sirmagul B., Linden A., Arzneim.-Forsch., 54, 371-375 (2004).
12. Simsek R., Safak C., Erol K., Sirmagul B., Pharmazie, 56, 665-666 (2001).
13. Simsek R., Safak C., Erol K., Ataman S., Ulgen M., Linden A., Arzneim.-Forsch., 53, 159-166 (2003).
14. Simsek R., Gunduz M. G., Sirmagul B., Safak C., Erol K., Linden A., Arzneim.-Forsch., 56, 529-534 (2006).
15. Simsek R., Ozkan M., Kismetli E., Uma S., Safak C., Farmaco, 59, 939-943 (2004).
16. Yamada S., Yamamura H. I., Roeske W. R., J. Pharmacol. Exp. Ther., 215, 176-185 (1980).
17. Yamada S., Ashizawa N., Ushijima H., Nakayama K., Hayashi E., Honda K., J. Pharmacol. Exp. Ther., 242, 326-330 (1987).
18. Yamada S., Kimura R., Harada Y., Nakayama K., J. Pharmacol. Exp. Ther., 252, 327-332 (1990).
19. Safak C., Sahin I., Sunal R., Arzneim.-Forsch., 40, 119-122 (1990).
20. Ehlert F. J., Tran L. P., J. Pharmacol. Exp. Ther., 255, 1148-1157 (1990).
21. Bo X., Fischer B., Maillard M., Jacobson K. A., Burnstock G., Br. J. Pharmacol., 112, 1151-1159 (1994).
22. Challinor-Rogers J. L., Kong D. C., Iskander M. N., McPherson G. A., J. Pharmacol. Exp. Ther., 273, 778-786 (1995).
23. Houghtling R. A., Davila-Garcia M. I., Kellar K. J., Mol. Pharmacol., 48, 280-287 (1995).
24. Ulich Y. M., Hargreaves K. M., Flores C. M., Neuropharmacology, 36, 1119-1125 (1997).
25. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J., J. Biol. Chem., 193, 265-275 (1951).
26. Yamada S., Matsuoka Y., Kato Y., Kimura R., Inagaki O., J. Pharmacol. Exp. Ther., 262, 589-594 (1992).
27. Yamada S., Isogai M., Kagawa Y., Takayanagi N., Hayashi E., Tsuji K., Kosuge T., Mol. Pharmacol., 28, 120-127 (1985).
28. Loev B., Goodman M. M., Snader M. K., Tedeschi R., Macko E., J. Med. Chem. 17, 956-965 (1974).
29. Triggle D. J., Langs D. A., Janis R. A., Med. Res. Rev., 9, 123-180 (1989).
30. Safak C., Simsek R., Mini. Rev. Med. Chem., 6, 747-755 (2006).
31. Frank C., Forst J. M., Grant T., Harris R. J., Kau S. T., Li J. H., Ohmmachb C. J., Smith R. W., Trainor D. A., Trivedi S., Med. Chem. Lett., 3, 2725-2726 (1993).
32. Li J. H., Cardiovasc. Drug Rev., 15, 220-231 (1997).
33. Trivedi S., Potter-Lee L., McConville M. W., Li J. H., Ohnmacht C. J., Trainor D. A., Kau S. T., Res. Commun. Mol. Phathol. Pharmacol., 88, 137-151 (1995).
34. Hamaguchi N., True T. A., Saussy D. L., Jeffs P. W., Biochemistry, 35, 14312-14317 (1996).
35. Nagarathnam D., Wetzel J. M., Miao S. W., Marzbadi M. R., Chiu G., Wong W. C., Hong X., Fang J., Forray C., Branchek T. A., Heydorn W. E., Chang R. S., Broten T., Schorn T. W., Gluchowski C., J. Med. Chem., 41, 5320-5333 (1998).
36. Wong W. C., Chiu G., Wetzel J. M., Marzabadi M. R., Nagarathnam D., Wang D., Fang J., Miao S. W., Hong X., Forray C., Vaysse P. J., Branchek T. A., Gluchowski C., Tang R., Lepor H., J. Med. Chem., 41, 2643-2650 (1998).