Some arylacridine derivatives possessing potassium channel opening activity

Farmaco

Volumn 59, Issue 12, 2004, Pages 939-943

  Şim̧ek, Rahime ^a   Özkan, Melike ^a   Kismetli, Emrah ^a   Uma, Serdar ^a   Şafak, Cihat ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Acridinedione; Potassium channel openers; Synthesis

Indexed keywords

ACRIDINE DERIVATIVE; PHENYLEPHRINE; PINACIDIL; POTASSIUM CHANNEL STIMULATING AGENT;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTERY DILATATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ISOLATED ARTERY; MALE; MESENTERIC ARTERY; NONHUMAN; RAT;

ACRIDINES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MESENTERIC ARTERIES; POTASSIUM CHANNELS; RATS; RATS, WISTAR; VASODILATION;

EID: 10344243488     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2004.07.011     Document Type: Article

References (19)

1. Horiuchi T., Dietrich H.H., Tsugane S., and Dacey R.G. Role of potassium channels in regulation of brain arteriolar tone Stroke 32 2001 218 224
2. Crestanello J.A., Doliba N.M., Babsky A.M., Debliba N.M., Niiobori K., Osbakken M., and Whitman G.J. Opening of potassium channels protects mitochondrial function from calcium overload J. Surg. Res. 94 2000 116 123
3. Liu Y., Ren G., Rourke B., Marban E., and Seharaseyon J. Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels Mol. Pharmacol. 59 2001 225 230
4. Lawson K. Potassium channel openers as potential therapeutic weapons in ion channel disease Kidney Int. 57 2000 838 845
5. + currents in smooth muscle cells from mouse gallbladder Am. J. Physiol. 274 1998 G687 G693
6. + currents by CGRP in gallbladder smooth muscle Am. J. Physiol. 267 1994 G494 G499
7. Grismer S. Potassium channels still hot Trends Pharmacol. Sci. 18 1997 347 350
8. Hoshi T., Zagotta W.N., and Aldrich R.W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation Science 250 1990 533 538
9. Zagotta W.N., Hoshi T., and Aldrich R.W. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB Science 250 1990 568 571
10. + channels in human T lymphocytes Biophys. J. 55 1989 203 206
11. Loev B., Goodmann M.M., Snader K.M., Tedeschi R., and Macko E. "Hantzsch-type" dihydropyridine hypotensive agents J. Med. Chem. 17 1974 956 965
12. ATP potassium channel openers Bioorg. Med. Chem. Lett. 3 1993 2725 2726
13. Sara̧ B., Aydin C., Şimşek R., Yildirim M.K., Koyuncu A., and Şafak C. Potassium channel opening activities of some acridine derivatives J. Hac. Univ.Pharm. Fac. 22 2002 49 55
14. Berkan O., Sara̧ B., Şimşek R., Yildirim A., Sarioǧlu Y., and Şafak C. Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries Eur. J. Med. Chem. 37 2002 519 523
15. U. Eisner, J. Kuthan, Chemistry of dihydropyridines, Chem. Rev. 72 (197) 1-42.
16. Sausins A., and Duburs G. Synthesis of 1,4-dihydropyridines by cyclocondensation reactions Heterocycles 27 1988 269 289
17. Şimşek R., Şafak C., Erol K., and Sirmagül B. Studies on calcium antagonist activities of 2-ethyl-3-carbmethoxy-4-aryl-5-oxo- 6,6-dimethyl-1,4,5,6,7,8-hexahydroquinoline derivatives Arzneim. Forsch. Drug Res. 51 2001 959 963
18. 2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery Br. J. Pharmacol. 138 2003 453 460
19. Cook N.S., and Haylett D.G. Effects of apamin, quinine and neuromuscular blockers on calcium- activated potassium channels in guinea-pig hepatocytes J. Physiol. 358 1985 373 394