Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-type potassium channels

Journal of Neuroscience

Volumn 22, Issue 15, 2002, Pages 6380-6387

  Burdakov, Denis ^a   Ashcroft, Frances M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

A currents; Appetite; Arcuate nucleus; CCK; CCK B receptor; Electrophysiology; Energy homeostasis; Hypothalamus

Indexed keywords

4 AMINOPYRIDINE; CALCIUM ION; CHOLECYSTOKININ; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; GASTRIN; POTASSIUM CHANNEL; SODIUM ION; TETRODOTOXIN;

ANIMAL CELL; ARCUATE NUCLEUS; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CONTROLLED STUDY; HYPERPOLARIZATION; HYPOTHALAMUS; MEMBRANE CURRENT; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; VOLTAGE CLAMP;

EID: 0036703629     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-15-06380.2002     Document Type: Article

References (48)

1. Aghajanian GK (1985) Modulation of a transient outward current in serotonergic neurons by α1-adrenoceptors. Nature 315:501-503.
2. Baldwin BA, Parrot RF, Ebenezer IS (1998) Food for thought: A critique on the hypothesis that endogenous cholecystokinin acts as a physiological satiety factor. Prog Neurobiol 55:477-507.
3. Barsch GS, Farooqi IS, O'Rahilly SO (2000) Genetics of body weight regulation. Nature 404:644-651.
4. Broadwell RD, Brightman MW (1976) Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 166:257-283.
5. Brown HF, DiFrancesco D, Noble SJ (1979) How does adrenaline accelerate the heart? Nature 280:235-236.
6. 2+ signals in the same cell. Curr Biol 10:993-996.
7. Ciofi P, Tramu G (1990) Distribution of cholecystokinin-like immunoreactive neurons in the guinea pig forebrain. J Comp Neurol 300:82-112.
8. Connor JA, Stevens CF (1971) Predictions of repetitive firing behaviour from voltage-clamp data on an isolated neuronal soma. J Physiol (Lond) 213:31-53.
9. Corp ES, Curcio M, Gibbs J, Smith GP (1997) The effect of centrally administered CCK-receptor antagonists on food intake in rats. Physiol Behav 61:823-827.
10. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Vone RD, Low MJ (2001) Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484.
11. Crawley JN, Corwin RL (1994) Biological actions of cholecystokinin. Peptides 4:731-755.
12. Dockray GJ (1978) Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain. Nature 274:711-713.
13. Dourish CT, Rycroft W, Iversen SD (1989) Postponement of satiety by blockade of brain cholecystokinin (CCK-B) receptors. Science 245:1509-1511.
14. Elias CF, Lee C, Kelly J, Aschkenasi C, Ahima RS, Couceyro PR, Kuhar MJ, Saper CB, Elmquist JK (1998) Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21:1375-1385.
15. Elmquist JK, Elias CF, Saper CB (1999) From lesions to leptin: Hypothalamic control of food intake and body weight. Neuron 22:221-232.
16. Franklin K, Paxinos G (1997) The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic.
17. h) in central neurons. Eur J Neurosci 12:2685-2693.
18. Ganong WF (2000) Circumventricular organs: Definition and role in the regulation of endocrine and autonomic function. Clin Exp Pharm Physiol 27:422-427.
19. Gibbs J, Young RC, Smith GP (1973) Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol 84:488-495.
20. Hahn TM, Breininger JF, Baskin DG, Schwartz MW (1998) Coexpression of Agrp and NPY in fasting activated hypothalamic neurons. Nat Neurosci 1:271-272.
21. Jensen RT, Wank SA, Rowley WH, Sato S, Gardner JD (1989) Interaction of CCK with pancreatic acinar cells. Trends Pharmacol Sci 10:418-423.
22. Kopin AS, Beinborn M, Lee Y-M, McBridge EW, Quinn SM (1994) The CCK-B/gastrin receptor. Ann NY Acad Sci 713:67-78.
23. Liddle RA, Goldfine ID, Williams JA (1984) Bioassay of plasma cholecystokinin in rats: Effects of food, trypsin inhibitor and alcohol. Gastroentereology 87:542-549.
24. Lieverse RJ, Jansen JBMJ, Masclee AAM, Lamers CBHW (1995) Satiety effects of a physiological dose of cholecystokinin in humans. Gut 36:176-179.
25. Liss B, Franz O, Sewing S, Bruns R, Neuhoff H, Roeper J (2001) Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and Kchip3.1 transcription. EMBO J 20:5715-5724.
26. Lüthi A, McCormick DA (1998) H-current: Properties of a neuronal and network pacemaker. Neuron 21:9-12.
27. McLaughlin A, Baile CA, Buonomo FC (1985) Meal-stimulated increased concentrations of CCK in the hypothalamus of Zucker obese and lean rats. Physiol Behav 35:215-220.
28. Miki T, Liss B, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J, Seino S (2001) ATP-sensitive K channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 4:507-512.
29. Minami T, Oomura Y, Sugimori M (1986) Electrophysiological properties and glucose responsiveness of guinea-pig ventromedial hypothalamic neurons in vitro. J Physiol (Lond) 380:127-143.
30. Moran TH (2000) Cholecystokinin and satiety: Current perspectives. Nutrition 16:858-865.
31. Noble F, Roques BP (1999) CCK-B receptor: Chemistry, molecular biology, biochemistry and pharmacology. Prog Neurobiol 58:349-379.
32. 2+ buffering. EMBO J 10:527-533.
33. Rauch M, Riediger T, Schmid HA, Simon E (2000) Orexin A activates leptin-responsive neurons in the arcuate nucleus. Pflügers Arch 440:699-703.
34. Rudy B (1988) Diversity and ubiquity of K channels. Neuroscience 25:729-749.
35. Scallet AC, Della-Fera MA, Baile CA (1985) Satiety, hunger and regional brain content of cholecystokinin/gastrin/gastrin and met-enkephalin immunoreactivity in the sheep. Peptides 6:937-943.
36. Schick RR, Yaksh TL, Go VLW (1986a) An intragastric meal releases the putative satiety factor cholecystokinin from hypothalamic neurons in cats. Brain Res 370:349-353.
37. Schick RR, Yaksh TL, Go VLM (1986b) Intracerebroventricular injections of cholecystokinin octapeptide suppress feeding in rats: Pharmacological characterisation of this action. Regul Peptides 14:277-292.
38. Schick RR, Reilly WM, Roddy DR, Yaksh TL, Go VLW (1987) Neuronal cholecystokinin-like immunoreactivity is postprandially released from primate hypothalamus. Brain Res 418:20-26.
39. Schick RR, Schusdziarra V, Enders C, Eberl T, Classen M (1991) Putative sleep factors and satiety in rats: Role of cholecystokinin (CCK) and delta sleep inducing peptide (DSIP). Neuropeptides 10:41-48.
40. Schwarz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661-671.
41. Siegel RA, Dueker EM, Pahnke U, Wuttke W (1987) Stress-induced changes in cholecystokinin and substance P in discrete regions of rat hypothalamus. Neuroendocrinology 46:74-81.
42. Sodersten P, Linden A (1992) Plasma and Cerebrospinal Fluid Concentrations of CCK and Satiety. Multiple Cholecystokinin Receptors in the CNS (Dourish CT, Cooper CJ, Iversen SD, Iversen LL, eds), pp 222-233. Oxford: Oxford UP.
43. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford MLJ (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390:521-525.
44. Spanswick D, Smith MA, Mirshamsi S, Routh VH, Ashford MLJ (2000) Insulin activates ATP-sensitive K channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 3:757-758.
45. Stuart G, Dodt H-U, Sakmann B (1993) Patch-clamp recordings from the soma and dendrites of neurons in brain slices using infrared video microscopy. Pflügers Arch 423:511-518.
46. Tsien RW, Lipscombe D, Madison DV, Bley KR, Fox AP (1988) Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci 11:431-438.
47. Wolfart J, Neuhoff H, Franz O, Roeper J (2001) Differential expression of the small conductance, calcium-activated potassium channel SK3 is critical for pacemaker control of dopaminergic midbrain neurons. J Neurosci 21:3443-3456.
48. Yang F, Feng L, Zheng F, Johnson SW, Du J, Shen L, Wu C-P, Lu B (2001) GNDF acutely modulates excitability and A-type K channels in midbrain dopaminergic neurons. Nat Neurosci 4:1071-1078.