A robust screen for novel antibiotics: Specific knockout of the initiator of bacterial DNA replication

FEMS Microbiology Letters

Volumn 281, Issue 2, 2008, Pages 210-214

  Fossum, Solveig ^a   De Pascale, Gianfranco ^b,e   Weigel, Christoph ^c   Messer, Walter ^d   Donadio, Stefano ^b,f   Skarstad, Kirsten ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b Vicuron Pharmaceuticals   (Italy)

^c TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

^d MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^e UNIVERSITY OF WARWICK   (United Kingdom)

^f Ktedogen Srl   (Italy)

Author keywords

Antibiotics; DNA replication; DnaA initiator protein; Escherichia coli; High throughput screening

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL DNA; DNA A; REPLICATION INITIATOR PROTEIN DNAA; REPLICATION INITIATOR PROTEIN DNAA INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DNA REPLICATION; DRUG SCREENING; ESCHERICHIA COLI; GENE DELETION; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ISOLATION; TEMPERATURE SENSITIVITY;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; DNA REPLICATION; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; GENE SILENCING; TEMPERATURE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 41049085230     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2008.01103.x     Document Type: Article

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