-
1
-
-
0347635518
-
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
-
Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS (2004). Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization, Proc. Natl. Acad. Sci. U.S.A., 101: 482-487.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A
, vol.101
, pp. 482-487
-
-
Aharoni, A.1
Gaidukov, L.2
Yagur, S.3
Toker, L.4
Silman, I.5
Tawfik, D.S.6
-
2
-
-
0032522985
-
Paraoxonase inhibits highdensity lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
-
Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parma SL, La Du BN (1998). Paraoxonase inhibits highdensity lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J. Clin. Invest, 101: 1581-590.
-
(1998)
J. Clin. Invest
, vol.101
, pp. 1581-1590
-
-
Aviram, M.1
Rosenblat, M.2
Bisgaier, C.L.3
Newton, R.S.4
Primo-Parma, S.L.5
La Du, B.N.6
-
3
-
-
0034642502
-
Selective plasma hydrolysis of glucocorticoid gammalactones and cyclic carbonates by the enzyme paraoxonase: An ideal plasma inactivation mechanism
-
Biggadike K, Angell RM, Burgess CM, Farrell RM, Hancock AP, Harker AJ, Irving WR, Ioannou C, Procopiou, PA, Shaw RE, Solanke YE, Singh OM Snowden M A, Stubbs R J, Walton S, Weston HE (2000). Selective plasma hydrolysis of glucocorticoid gammalactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism, J. Med. Chem 43: 19-21.
-
(2000)
J. Med. Chem
, vol.43
, pp. 19-21
-
-
Biggadike, K.1
Angell, R.M.2
Burgess, C.M.3
Farrell, R.M.4
Hancock, A.P.5
Harker, A.J.6
Irving, W.R.7
Ioannou, C.8
Procopiou, P.A.9
Shaw, R.E.10
Solanke, Y.E.11
Singh, O.M.12
Snowden, M.A.13
Stubbs, R.J.14
Walton, S.15
Weston, H.E.16
-
4
-
-
0033783020
-
Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters
-
Billecke S, Draganov D, Counsell R, Stetson P, Watson C, Hsu C, La Du BN (2000). Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos 28: 1335-1342.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 1335-1342
-
-
Billecke, S.1
Draganov, D.2
Counsell, R.3
Stetson, P.4
Watson, C.5
Hsu, C.6
La Du, B.N.7
-
5
-
-
0024272631
-
Sulfonylurea receptors, ion channels and fruit flies
-
Boyd AE (1988). Sulfonylurea receptors, ion channels and fruit flies. Diabetes; 37: 847-850.
-
(1988)
Diabetes
, vol.37
, pp. 847-850
-
-
Boyd, A.E.1
-
6
-
-
0017184389
-
A rapid and sensitive method for the quantition of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM (1976). A rapid and sensitive method for the quantition of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72: 248-251.
-
(1976)
Anal. Biochem
, vol.72
, pp. 248-251
-
-
Bradford, M.M.1
-
7
-
-
0037639963
-
Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effects on Pesticide Sensitivty, Cardiovascular Disease, and Drug Metabolism
-
Costa LG, Cole TB, Jarvik GP, Furlong EF (2003). Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effects on Pesticide Sensitivty, Cardiovascular Disease, and Drug Metabolism, Annu. Rev. Med, 54: 371.
-
(2003)
Annu. Rev. Med
, vol.54
, pp. 371
-
-
Costa, L.G.1
Cole, T.B.2
Jarvik, G.P.3
Furlong, E.F.4
-
8
-
-
0030293198
-
The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin
-
Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE (1996). The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat. Genet 14: 334-336.
-
(1996)
Nat. Genet
, vol.14
, pp. 334-336
-
-
Davies, H.G.1
Richter, R.J.2
Keifer, M.3
Broomfield, C.A.4
Sowalla, J.5
Furlong, C.E.6
-
9
-
-
0034677966
-
Drug discovery: A historical perspective
-
Drew J (2000) Drug discovery: A historical perspective. Science 287: 1960-1964.
-
(2000)
Science
, vol.287
, pp. 1960-1964
-
-
Drew, J.1
-
11
-
-
0020534463
-
The human serum paraoxonase polymorphism:dentification of phenotypes by their response to salts
-
Eckerson HW, Romson J, Wyte C, La Du BN (1983). The human serum paraoxonase polymorphism:dentification of phenotypes by their response to salts. Am. J. Hum. Genet. 35:214-227.
-
(1983)
Am. J. Hum. Genet
, vol.35
, pp. 214-227
-
-
Eckerson, H.W.1
Romson, J.2
Wyte, C.3
La Du, B.N.4
-
12
-
-
0022894910
-
Identity of the polymorphisms for esterase D and Sformylglutathione hydrolase in red blood cells
-
Eiberg H, Mohr J (1986). Identity of the polymorphisms for esterase D and Sformylglutathione hydrolase in red blood cells. Hum Genet, 74: 174-175.
-
(1986)
Hum Genet
, vol.74
, pp. 174-175
-
-
Eiberg, H.1
Mohr, J.2
-
13
-
-
0026096803
-
Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities
-
Gan KN, Smolen A, Eckerson HW, La Du BN (1991). Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities, Drug Metab. Dispos. 19: 100-106.
-
(1991)
Drug Metab. Dispos
, vol.19
, pp. 100-106
-
-
Gan, K.N.1
Smolen, A.2
Eckerson, H.W.3
La Du, B.N.4
-
14
-
-
84984763419
-
Corrigendum: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes
-
Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS (2004). Corrigendum: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes, Nat. Struct. Mol. Biol. 11: 1253.
-
(2004)
Nat. Struct. Mol. Biol
, vol.11
, pp. 1253
-
-
Harel, M.1
Aharoni, A.2
Gaidukov, L.3
Brumshtein, B.4
Khersonsky, O.5
Meged, R.6
Dvir, H.7
Ravelli, R.B.8
McCarthy, A.9
Toker, L.10
Silman, I.11
Sussman, J.L.12
Tawfik, D.S.13
-
15
-
-
0025719481
-
Characterisation of cDNA clones encoding rabbit andhuman serum paraoxonase: The mature protein retains itssignal sequence
-
Hassett C, Richter RJ, Humbert R, Chapline C, Crabb JW, Omiecinski CJ, Furlong CE (1991). Characterisation of cDNA clones encoding rabbit andhuman serum paraoxonase: the mature protein retains itssignal sequence. Biochemistry, 30: 10141-10149.
-
(1991)
Biochemistry
, vol.30
, pp. 10141-10149
-
-
Hassett, C.1
Richter, R.J.2
Humbert, R.3
Chapline, C.4
Crabb, J.W.5
Omiecinski, C.J.6
Furlong, C.E.7
-
16
-
-
0028862927
-
Interindividual variation in carboxylesterase levels in human liver microsomes
-
Hosokawa M, Endo T, Fujisawa M, Hara S, Iwata N, Sato Y, Satoh T (1995). Interindividual variation in carboxylesterase levels in human liver microsomes. Drug Metab. Dispos. 23: 1022-1027.
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 1022-1027
-
-
Hosokawa, M.1
Endo, T.2
Fujisawa, M.3
Hara, S.4
Iwata, N.5
Sato, Y.6
Satoh, T.7
-
17
-
-
0034635449
-
Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein n-homocysteinylation
-
Jakubowski H (2000). Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein n-homocysteinylation. J. Biol. Chem., 275: 3957-3962.
-
(2000)
J. Biol. Chem
, vol.275
, pp. 3957-3962
-
-
Jakubowski, H.1
-
18
-
-
17644367506
-
Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
-
Khersonsky O, Tawfik DS (2005). Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase, Biochemistry 44: 6371-6382.
-
(2005)
Biochemistry
, vol.44
, pp. 6371-6382
-
-
Khersonsky, O.1
Tawfik, D.S.2
-
19
-
-
33646373929
-
The Histidine 115-Histidine 134 Dyad Mediates the Lactonase Activity of Mammalian Serum Paraoxonase
-
Khersonsky O, Tawfik DS (2006). The Histidine 115-Histidine 134 Dyad Mediates the Lactonase Activity of Mammalian Serum Paraoxonase. J. Biol. Chem. 281(11): 7649-7656.
-
(2006)
J. Biol. Chem
, vol.281
, Issue.11
, pp. 7649-7656
-
-
Khersonsky, O.1
Tawfik, D.S.2
-
20
-
-
0028824970
-
Metabolism and pharmacokinetics of a double prodrug of ganciclovir in the rat and monkey
-
Krasny HC, Beauchamp L, Krenitsky TA, Miranda PD (1995). Metabolism and pharmacokinetics of a double prodrug of ganciclovir in the rat and monkey. Drug Metab. Dispos. 23: 1242-247.
-
(1995)
Drug Metab. Dispos
, vol.23
, pp. 1242-1247
-
-
Krasny, H.C.1
Beauchamp, L.2
Krenitsky, T.A.3
Miranda, P.D.4
-
21
-
-
0034648768
-
Atherosclerosis
-
Lusis AJ (2000). Atherosclerosis. Nature 407: 233-241.
-
(2000)
Nature
, vol.407
, pp. 233-241
-
-
Lusis, A.J.1
-
22
-
-
0027763632
-
Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase
-
Mackness MI, Arrol S, Abbott C, Durrington PN (1993). Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis, 104: 129-135.
-
(1993)
Atherosclerosis
, vol.104
, pp. 129-135
-
-
Mackness, M.I.1
Arrol, S.2
Abbott, C.3
Durrington, P.N.4
-
23
-
-
0016912115
-
Relations between structure and biological activity of sulfonamides
-
Maren TH (1976). Relations between structure and biological activity of sulfonamides. Annu. Rev. Pharmacol. Toxicol. 16:.309-327.
-
(1976)
Annu. Rev. Pharmacol. Toxicol
, vol.16
, pp. 309-327
-
-
Maren, T.H.1
-
24
-
-
0006390275
-
-
McGuire MC, Nogueira CP, Bartels CF, Lightstone H, Hajra A, Van der Spek AFL, Lockridge O, La Du BN (1989). Identification of the structural mutation responsible for the dibucaineresistant (atypical) variant form of human serum cholinesterase. Proc. Natl. Acad. Sci. USA, 86: 953-957.
-
McGuire MC, Nogueira CP, Bartels CF, Lightstone H, Hajra A, Van der Spek AFL, Lockridge O, La Du BN (1989). Identification of the structural mutation responsible for the dibucaineresistant (atypical) variant form of human serum cholinesterase. Proc. Natl. Acad. Sci. USA, 86: 953-957.
-
-
-
-
25
-
-
9444273419
-
Prodrugs of BMS-183920
-
Obermeier MT, Chong S, Dando SA, Marino AM, Ryono DE, Starret-Arroyo A, Didonato GC, Warrack BM, White RE, Morrison RA (1996). Prodrugs of BMS-183920. J. Pharm. Sci. 85: 828-833.
-
(1996)
J. Pharm. Sci
, vol.85
, pp. 828-833
-
-
Obermeier, M.T.1
Chong, S.2
Dando, S.A.3
Marino, A.M.4
Ryono, D.E.5
Starret-Arroyo, A.6
Didonato, G.C.7
Warrack, B.M.8
White, R.E.9
Morrison, R.A.10
-
26
-
-
0003658456
-
-
Ogden RC, Flexner CW, editors , New York, Basel: Marcel Dekker
-
Ogden RC, Flexner CW, editors (2001). Protease Inhibitors in AIDS Therapy. New York, Basel: Marcel Dekker.
-
(2001)
Protease Inhibitors in AIDS Therapy
-
-
-
27
-
-
0017200192
-
Genetic polymorphism and interethnic variability of plasma paraoxonase activity
-
Playfer JR, Eze CL, Bullen MF, Evans DAP (1976). Genetic polymorphism and interethnic variability of plasma paraoxonase activity. J. Med. Genet. 13: 337-342.
-
(1976)
J. Med. Genet
, vol.13
, pp. 337-342
-
-
Playfer, J.R.1
Eze, C.L.2
Bullen, M.F.3
Evans, D.A.P.4
-
28
-
-
0029937118
-
-
Primo-Parmo SL Sorenson RC, Teiber J, La Du BN (1996). The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics, 33: 498-507.
-
Primo-Parmo SL Sorenson RC, Teiber J, La Du BN (1996). The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics, 33: 498-507.
-
-
-
-
29
-
-
0000191215
-
Role of carboxylesterases in xenobiotic metabolism
-
Satoh T (1987). Role of carboxylesterases in xenobiotic metabolism. Rev Biochem Toxicol, 8: 155-181.
-
(1987)
Rev Biochem Toxicol
, vol.8
, pp. 155-181
-
-
Satoh, T.1
-
30
-
-
0029863926
-
The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs
-
Senter PD, Marquardt H, Thomas BA, Hammock BD, Frank IS, Svensson HP (1996). The role of rat serum carboxylesterase in the activation of paclitaxel and camptothecin prodrugs. Cancer Res, 56: 1471-1474.
-
(1996)
Cancer Res
, vol.56
, pp. 1471-1474
-
-
Senter, P.D.1
Marquardt, H.2
Thomas, B.A.3
Hammock, B.D.4
Frank, I.S.5
Svensson, H.P.6
-
31
-
-
0034609778
-
Carbonic anhydrase and matrix metalloproteinase inhibitors. Sulfonylated amino acid hydroxamates withMMP inhibitory properties act as efficient inhibitors of carbonic anhydrase isozymes I, II and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes
-
Scozzafava A, Supuran CT (2000). Carbonic anhydrase and matrix metalloproteinase inhibitors. Sulfonylated amino acid hydroxamates withMMP inhibitory properties act as efficient inhibitors of carbonic anhydrase isozymes I, II and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J. Med. Chem. 43: 3677-3687.
-
(2000)
J. Med. Chem
, vol.43
, pp. 3677-3687
-
-
Scozzafava, A.1
Supuran, C.T.2
-
32
-
-
33745030576
-
Novel Purification Strategy For Human PON1 And Inhibition Of The Activity By Cephalosporin And Aminoglikozide Derived Antibiotics
-
Sinan S, Kockar F, Arslan O (2006). Novel Purification Strategy For Human PON1 And Inhibition Of The Activity By Cephalosporin And Aminoglikozide Derived Antibiotics, Biochimie., 88: 565-574.
-
(2006)
Biochimie
, vol.88
, pp. 565-574
-
-
Sinan, S.1
Kockar, F.2
Arslan, O.3
-
34
-
-
40949159511
-
-
Supuran CT. (2002). Indisulam. IDrugs, 5 :1075-1079. Supuran CT, Scozzafava A, Casini A (2003). Carbonic anhydrase inhibitors. Med. Res. Rev., 23: 146-189.
-
Supuran CT. (2002). Indisulam. IDrugs, 5 :1075-1079. Supuran CT, Scozzafava A, Casini A (2003). Carbonic anhydrase inhibitors. Med. Res. Rev., 23: 146-189.
-
-
-
-
35
-
-
0036166662
-
Applications of carbonic anhydrase inhibitors and activators in therapy
-
Supuran CT, Scozzafava A (2002). Applications of carbonic anhydrase inhibitors and activators in therapy. Exp. Opin. Ther. Patents; 12: 217-242.
-
(2002)
Exp. Opin. Ther. Patents
, vol.12
, pp. 217-242
-
-
Supuran, C.T.1
Scozzafava, A.2
-
37
-
-
0029849446
-
Carbonic anhydrase inhibitors. Synthesis and inhibitory properties of 1,3,4-thiadiazole-2,5-bissulfonamide
-
Supuran CT, ConroyCW, Maren TH (1996). Carbonic anhydrase inhibitors. Synthesis and inhibitory properties of 1,3,4-thiadiazole-2,5-bissulfonamide. Eur. J. Med. Chem. 31: 843-846.
-
(1996)
Eur. J. Med. Chem
, vol.31
, pp. 843-846
-
-
Supuran, C.T.1
Conroy, C.W.2
Maren, T.H.3
-
38
-
-
0041919643
-
-
Medicine research rewievs
-
Supuran CT, Casini A, Scozzafava (2003). Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents, Medicine research rewievs, 23(5): 535-558.
-
(2003)
Protease inhibitors of the sulfonamide type: Anticancer, antiinflammatory, and antiviral agents
, vol.23
, Issue.5
, pp. 535-558
-
-
Supuran, C.T.1
Casini, A.2
Scozzafava3
-
39
-
-
0028587863
-
Variable activation of lovastatin by hydrolytic enzymes in human plasma and liver
-
Tang BK, Kalow W (1995). Variable activation of lovastatin by hydrolytic enzymes in human plasma and liver. Eur. J. Clin. Pharmacol., 47: 449-451.
-
(1995)
Eur. J. Clin. Pharmacol
, vol.47
, pp. 449-451
-
-
Tang, B.K.1
Kalow, W.2
-
40
-
-
0006908514
-
Isosterism and molecular modification in drug design
-
Thornber CW (1979). Isosterism and molecular modification in drug design. Chem. Soc. Rev., 8: 563-580.
-
(1979)
Chem. Soc. Rev
, vol.8
, pp. 563-580
-
-
Thornber, C.W.1
-
41
-
-
0014217102
-
Esterase activities of human carbonic anhydrase B and C
-
Verpoorte JA, Mehta S, Edsall JT (1967). Esterase activities of human carbonic anhydrase B and C. J. Biol. Chem, 242: 4221-4229.
-
(1967)
J. Biol. Chem
, vol.242
, pp. 4221-4229
-
-
Verpoorte, J.A.1
Mehta, S.2
Edsall, J.T.3
-
42
-
-
0021996062
-
Clinical significance of esterases in man
-
Williams FM (1985). Clinical significance of esterases in man. Clin. Pharmacokinet, 10: 392-403.
-
(1985)
Clin. Pharmacokinet
, vol.10
, pp. 392-403
-
-
Williams, F.M.1
|