Thujone-attributable effects of absinthe are only an urban leg-end - Toxicology uncovers alcohol as real cause of absinthism;Thujon-wirkungen von absinth sind nur eine Legende - Toxikologie entlarvt alkohol als eigentliche absinthismus-ursache

Medizinische Monatsschrift fur Pharmazeuten

Volumn 31, Issue 3, 2008, Pages 101-106

  Lachenmeier, Dirk W ^a  

^a Chemisches und Veterinäruntersuchungsamt ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABSINTHOL; ALCOHOL;

ALCOHOL ABUSE; ALCOHOL INTOXICATION; ALCOHOLIC BEVERAGE; ALCOHOLISM; DRINKING BEHAVIOR; FRANCE; HISTORY OF MEDICINE; HUMAN; REVIEW;

ABSINTHE; ALCOHOLISM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; HISTORY, 19TH CENTURY; HISTORY, 20TH CENTURY; HUMANS; MONOTERPENES;

EID: 40949137037     PISSN: 03429601     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (46)

1. Borzelleca JF. Paracelsus: herald of modern toxicology. Toxicol Sci 2000;53:2-4.
2. Bielenberg J. Zentralnervöse Effekte durch Thujon. Med Monatsschr Pharm 2007;30:322-6.
3. Lachenmeier DW. General misconceptions about the wormwood-flavoured spirit absinthe. FoodInfo Online 2007;www.foodsciencecentral. com/fsc/ixid14644.
4. Lachenmeier DW, Walch SG, Padosch SA, Kröner LU. Absinthe - A review. Crit Rev Food Sci Nutr 2006;46:365-77.
5. Lachenmeier DW. Assessing the authenticity of absinthe using sensory evaluation and HPTLC analysis of the bitter principle absinthin. Food Res Int 2007;40:167-75.
6. WHO. Thujone. Toxicological evaluation of certain food additives WHO food additives series 1981:16.
7. Scientific Committee on Food of the European Commission. Opinion of the Scientific Committee on Food on Thujone. http://europa.eu.int/ comm/food/fs/sc/scf/index_en.html; 2003.
8. Richtlinie des Rates vom 22. Juni 1998 zur Angleichung der Rechtsvorschriften der Mitgliedstaaten über Aromen zur Verwendung in Lebensmitteln und über Ausgangsstoffe für ihre Herstellung (88/388/EWG). Amtsbl Europ Gem 1988;L184:61-6.
9. Aromenverordnung. BGBl I 1981;1625 (neugefasst 2006 BGBl I 1127).
10. Codex alimentarius. General requirements for natural flavourings (CAC/ GL 29.1987). www.codexalimentarius.net; 1985.
11. European Parliament and Council. Proposal for a regulation of the European parliament and of the council on flavourings and certain food ingredients with flavouring properties for use in and on foods. http:// ec.europa.eu/food/food/chemicalsafety/additives/com2006_427_en. pdf; 2006.
12. Alcohol and Tobacco Tax and Trade Bureau. Certificate of label approval. TTB ID 07064-000-000076. https://www.ttbonline.gov/colasonline/ viewColaDetails do?action=publicDisplaySearchBasic&ttbid=0706400 0000076; 2007.
13. Hein J, Lobbedey L, Neumärker KJ. Absinth - Neue Mode, alte Probleme. Dtsch Ärztebl 2001;98:A2716-24.
14. Holstege CP, Baylor MR, Rusyniak DE. Absinthe: return of the green fairy. Semin Neurol 2002;22:89-93.
15. Müller O. Wermut - gefährliches Kraut in harmloser Verpackung. Zahnärztl Mitt 2002;92:78.
16. Strang J, Arnold WN, Peters T. Absinthe: what's your poison? Br Med J 1999;319:1590-2.
17. Arnold WN. Vincent van Gogh: chemicals, crises, and creativity. Boston, MA, USA: Birkhäuser, 1992.
18. Lachenmeier DW, Nathan-Maister D. Systematic misinformation about thujone in pre-ban absinthe. Dtsch Lebensmittel Rundschau 2007;103:255-62.
19. Rychlak B. Total thujone and anethole concentrations in various alcoholic beverages, including pre-ban absinthe. Dtsch Lebensmittel Rundschau 2007;103:419-24.
20. Bedel A. Traité complet de la fabrication des liqueurs. Paris, France: Garnier Frères, 1899.
21. Lachenmeier DW, Kuballa T. Behaviour of thujone during distillation and possible concentration ranges in pre-ban absinthe. J Sci Food Agric 2007;87:2147-51.
22. Hutton I. Myth, reality and absinthe. Curr Drug Discov 2002;9:62-4.
23. Schaefer I, Bindler F, Lugnier A. Toxicological rehabilitation of absinthium liqueur. Toxicol Lett 1994;74(Suppl 1):75.
24. Lachenmeier DW, Emmert J, Kuballa T, Sartor G. Thujone - Cause of absinthism? Forensic Sci Int 2006;158:1-8.
25. 3 receptor activity by an effect on the agonist-reduced desensitization. Neuropharmacology 2004;46:192-201.
26. Dettling A, Grass H, Schuff A, Skopp G, et al. Absinthe: attention performance and mood under the influence of thujone. J Stud Alcohol 2004;65:573-81.
27. Manzo L, Locatelli C, Candura SM, Costa LG. Nutrition and alcohol neurotoxicity. Neurotoxicology 1994;15:555-65.
28. Huisman M, Brug J, Mackenbach J. Absinthe - is its history relevant for current public health? Int J Epidemiol 2007;36:738-44.
29. Walker EE. The effects of absinthe. Med Rec 1906;13:568-72.
30. Amory R. Experiments and observations on absinth and absinthism. Boston Med Surg J 1868;1:68-71, 83-5.
31. Magnan V. Accidents déterminés par l'abus de la liqueur d'absinthe. L'union médicale 1864;92&94:227-32, 257-62.
32. Magnan V. On the comparative action of alcohol and absinthe. Lancet 1874;104:410-2.
33. Magnan V, Fillassier A. Alcoholism and degeneracy. Statistics of the central service for the admission of insane persons for the town of Paris and for the department of the Seine, from 1867-1912. Problems in Eugenics. Papers communicated to the First International Eugenics Conference held at the University of London July 24th to 30th, 1912. Adelphi, W.C.: The Eugenics Education Society, 1912.
34. Boyce R. A contribution to the study of descending degenerations in the brain and spinal cord, and of the seat of origin and paths of conduction of the fits in absinthe epilepsy. Phil Transact Royal Soc 1895;186:321-82.
35. Ott I. The seat of absinthic epilepsy. J Nerv Ment Dis 1892;19:696-8.
36. Padosch SA, Lachenmeier DW, Kröner LU. Absinthism: a fictitious 19th century syndrome with present impact. Subst Abuse Treat Prev Policy 2006;1:14. http://www.substanceabusepolicy.com/content/1/1/14 (open access)
37. Albert-Puleo M. Mythobotany, pharmacology, and chemistry of thujone - containing plants and derivatives. Econ Bot 1978;32:65-74.
38. Höld KM, Sirisoma NS, Ikeda T, Narahashi T, et al. α-Thujone (the active component of absinthe): γ-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci U S A 2000;97:3826-31.
39. Olsen RW. Absinthe and γ-aminobutyric acid receptors. Proc Natl Acad Sci U S A 2000;97:4417-8.
40. Weisbord SD, Soule JB, Kimmel PL. Poison on line - acute renal failure caused by oil of wormwood purchased through the Internet. N Engl J Med 1997;337:825-7.
41. Omer B, Krebs S, Omer H, Noor TO. Steroid-sparing effect of wormwood (Artemisia absinthium) in Crohn's disease: a double-blind placebo-controlled study. Phytomedicine 2007;14:87-95.
42. Anon. Bitter, grün und hochprozentig. Unizeit (Universität Kiel) 2006;34:2.
43. Fröhlich O, Shibamoto T. Stability of pulegone and thujone in ethanolic solution. J Agric Food Chem 1990;38:2057-60.
44. Eastman RH, Winn AV. The isomerization of thujone. J Am Chem Soc 1960;82:5908-14.
45. von Doering E, Willcott MR, Jones M. The structure of two minor products of the pyrolysis of thujone. J Am Chem Soc 1962;84:1224-8.
46. Modegetränk Absinth: BfR rät beim Konsum zur Vorsicht! Berlin: Bundesinstitut für Risikobewertung Pressedienst 15/2003.