HIC1 tumour suppressor gene is suppressed in acute myeloid leukaemia and induced during granulocytic differentiation

British Journal of Haematology

Volumn 141, Issue 2, 2008, Pages 179-187

  Britschgi, Christian ^a   Jenal, Mathias ^a   Rizzi, Mattia ^a   Mueller, Beatrice U ^b   Torbett, Bruce E ^c   Andres, Anne Catherine ^a   Tobler, Andreas ^a,b   Fey, Martin F ^a,b   Tschan, Mario P ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Acute myeloid leukaemia; All trans retinoic acid; Granulocytic differentiation; Hypermethylated in cancer 1 gene

Indexed keywords

BISULFITE; CD11B ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; MESSENGER RNA; RETINOIC ACID; SHORT HAIRPIN RNA;

ACUTE GRANULOCYTIC LEUKEMIA; AMINO ACID SEQUENCE; ANTIGEN EXPRESSION; ARTICLE; CD34 SELECTION; CELL DIFFERENTIATION; CELL STRAIN HL 60; CELL STRAIN U937; CONTROLLED STUDY; CPG ISLAND; GC RICH SEQUENCE; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENE REPRESSION; GENE SEQUENCE; GENE TARGETING; GRANULOCYTE; HUMAN; HUMAN CELL; HYPERMETHYLATED IN CANCER 1; METHYLATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROMYELOCYTIC LEUKEMIA; STEM CELL; TUMOR SUPPRESSOR GENE;

ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA METHYLATION; GENE EXPRESSION REGULATION; GRANULOCYTES; HL-60 CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LEUKEMIA, MYELOID, ACUTE; LEUKEMIA, PROMYELOCYTIC, ACUTE; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; RNA, NEOPLASM; TRETINOIN; U937 CELLS; UP-REGULATION;

EID: 40949125288     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.06992.x     Document Type: Article

References (34)

1. Aggerholm, A., Holm, M.S., Guldberg, P., Olesen, L.H. Hokland, P. (2006) Promoter hypermethylation of p15INK4B, HIC1, CDH1, and ER is frequent in myelodysplastic syndrome and predicts poor prognosis in early-stage patients. European Journal of Haematology, 76, 23 32.
2. Ahuja, N., Mohan, A.L., Li, Q., Stolker, J.M., Herman, J.G., Hamilton, S.R., Baylin, S.B. Issa, J.P. (1997) Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Research, 57, 3370 3374.
3. Bergmann, L., Maurer, U. Weidmann, E. (1997a) Wilms tumor gene expression in acute myeloid leukemias. Leukemia and Lymphoma, 25, 435 443.
4. Bergmann, L., Miething, C., Maurer, U., Brieger, J., Karakas, T., Weidmann, E. Hoelzer, D. (1997b) High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome. Blood, 90, 1217 1225.
5. Britschgi, C., Rizzi, M., Grob, T.J., Tschan, M.P., Hugli, B., Reddy, V.A., Andres, A.C., Torbett, B.E., Tobler, A. Fey, M.F. (2006) Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1. Oncogene, 25, 2030 2039.
6. Carter, M.G., Johns, M.A., Zeng, X., Zhou, L., Zink, M.C., Mankowski, J.L., Donovan, D.M. Baylin, S.B. (2000) Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome. Human Molecular Genetics, 9, 413 419.
7. Chen, W.Y., Zeng, X., Carter, M.G., Morrell, C.N., Chiu Yen, R.W., Esteller, M., Watkins, D.N., Herman, J.G., Mankowski, J.L. Baylin, S.B. (2003) Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nature Genetics, 33, 197 202.
8. Chen, W.Y., Wang, D.H., Yen, R.C., Luo, J., Gu, W. Baylin, S.B. (2005) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell, 123, 437 448.
9. Colotta, F., Peri, G., Villa, A. Mantovani, A. (1984) Rapid killing of actinomycin D-treated tumor cells by human mononuclear cells. I. Effectors belong to the monocyte-macrophage lineage. Journal of Immunology, 132, 936 944.
10. Deltour, S., Guerardel, C. Leprince, D. (1999) Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for /POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proceedings of the National Academy of Sciences of the United States of America, 96, 14831 14836.
11. Dong, S.M., Kim, H.S., Rha, S.H. Sidransky, D. (2001) Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clinical Cancer Research, 7, 1982 1986.
12. Fujii, H., Biel, M.A., Zhou, W., Weitzman, S.A., Baylin, S.B. Gabrielson, E. (1998) Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer. Oncogene, 16, 2159 2164.
13. Guerardel, C., Deltour, S., Pinte, S., Monte, D., Begue, A., Godwin, A.K. Leprince, D. (2001) Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53. The Journal of Biological Chemistry, 276, 3078 3089.
14. Heltweg, B., Gatbonton, T., Schuler, A.D., Posakony, J., Li, H., Goehle, S., Kollipara, R., Depinho, R.A., Gu, Y., Simon, J.A. Bedalov, A. (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research, 66, 4368 4377.
15. Issa, J.P., Zehnbauer, B.A., Kaufmann, S.H., Biel, M.A. Baylin, S.B. (1997) HIC1 hypermethylation is a late event in hematopoietic neoplasms. Cancer Research, 57, 1678 1681.
16. Krug, U., Ganser, A. Koeffler, H.P. (2002) Tumor suppressor genes in normal and malignant hematopoiesis. Oncogene, 21, 3475 3495.
17. Langley, E., Pearson, M., Faretta, M., Bauer, U.M., Frye, R.A., Minucci, S., Pelicci, P.G. Kouzarides, T. (2002) Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO Journal, 21, 2383 2396.
18. Lapillonne, H., Renneville, A., Auvrignon, A., Flamant, C., Blaise, A., Perot, C., Lai, J.L., Ballerini, P., Mazingue, F., Fasola, S., Dehee, A., Bellman, F., Adam, M., Labopin, M., Douay, L., Leverger, G., Preudhomme, C. Landman-Parker, J. (2006) High WT1 expression after induction therapy predicts high risk of relapse and death in pediatric acute myeloid leukemia. Journal of Clinical Oncology, 24, 1507 1515.
19. Li, L.C. Dahiya, R. (2002) MethPrimer: designing primers for methylation PCRs. Bioinformatics, 18, 1427 1431.
20. Livak, K.J. Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2[-Delta Delta C(T)] method. Methods, 25, 402 408.
21. Melki, J.R., Vincent, P.C. Clark, S.J. (1999a) Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia. Leukemia, 13, 877 883.
22. Melki, J.R., Vincent, P.C. Clark, S.J. (1999b) Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Research, 59, 3730 3740.
23. Ogawa, H., Tamaki, H., Ikegame, K., Soma, T., Kawakami, M., Tsuboi, A., Kim, E.H., Hosen, N., Murakami, M., Fujioka, T., Masuda, T., Taniguchi, Y., Nishida, S., Oji, Y., Oka, Y. Sugiyama, H. (2003) The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia. Blood, 101, 1698 1704.
24. Ota, H., Tokunaga, E., Chang, K., Hikasa, M., Iijima, K., Eto, M., Kozaki, K., Akishita, M., Ouchi, Y. Kaneki, M. (2006) Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene, 25, 176 185.
25. Pinte, S., Stankovic-Valentin, N., Deltour, S., Rood, B.R., Guerardel, C. Leprince, D. (2004) The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. The Journal of Biological Chemistry, 279, 38313 38324.
26. Quere, R., Baudet, A., Cassinat, B., Bertrand, G., Marti, J., Manchon, L., Piquemal, D., Chomienne, C. Commes, T. (2007) Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood, 109, 4450 4460.
27. Stocklein, H., Smardova, J., Macak, J., Katzenberger, T., Holler, S., Wessendorf, S., Hutter, G., Dreyling, M., Haralambieva, E., Mader, U., Muller-Hermelink, H.K., Rosenwald, A., Ott, G. Kalla, J. (2007) Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma. Oncogene Epub ahead of print).
28. Sundstrom, C. Nilsson, K. (1976) Establishment and characterization of a human histiocytic lymphoma cell line (U-937). International Journal of Cancer, 17, 565 577.
29. Tallman, M.S. (1996) Differentiating therapy with all-trans retinoic acid in acute myeloid leukemia. Leukemia, 10 (Suppl 1 S12 S15.
30. Tamaki, H., Mishima, M., Kawakami, M., Tsuboi, A., Kim, E.H., Hosen, N., Ikegame, K., Murakami, M., Fujioka, T., Masuda, T., Taniguchi, Y., Nishida, S., Osumi, K., Soma, T., Oji, Y., Oka, Y., Kawase, I., Sugiyama, H. Ogawa, H. (2003) Monitoring minimal residual disease in leukemia using real-time quantitative polymerase chain reaction for Wilms tumor gene (WT1). International Journal of Hematology, 78, 349 356.
31. Tschan, M.P., Vonlanthen, S., Cajot, J.F., Peters, U.R., Oppliger, E., Betticher, D.C., Yarbrough, W.G., Fey, M.F. Tobler, A. (2001) Different p16INK4a and p14ARF expression patterns in acute myeloid leukaemia and normal blood leukocytes. Leukemia and Lymphoma, 42, 1077 1087.
32. Tschan, M.P., Fischer, K.M., Fung, V.S., Pirnia, F., Borner, M.M., Fey, M.F., Tobler, A. Torbett, B.E. (2003) Alternative splicing of the human cyclin D-binding Myb-like protein (hDMP1) yields a truncated protein isoform that alters macrophage differentiation patterns. The Journal of Biological Chemistry, 278, 42750 42760.
33. Vaziri, H., Dessain, S.K., Ng Eaton, E., Imai, S.I., Frye, R.A., Pandita, T.K., Guarente, L. Weinberg, R.A. (2001) hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell, 107, 149 159.
34. Wales, M.M., Biel, M.A., el Deiry, W., Nelkin, B.D., Issa, J.P., Cavenee, W.K., Kuerbitz, S.J. Baylin, S.B. (1995) p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nature Medicine, 1, 570 577.