Two-generation reproductive toxicity evaluation of dietary 17β-Estradiol (E2; CAS No. 50-28-2) in CD-1 (Swiss) mice

Toxicological Sciences

Volumn 102, Issue 2, 2008, Pages 392-412

  Tyl, Rochelle W ^a   Myers, Christina B ^a   Marr, Melissa C ^a   Sloan, Carol S ^a   Castillo, Nora P ^a   Veselica, M Michael ^a   Seely, John C ^b   Dimond, Stephen S ^c   Van miller, John P ^d   Shiotsuka, Ronald S ^e   Stropp, Gisela D ^f   Waechter, John M ^g   Hentges, Steven G ^h  

^a RTI INTERNATIONAL   (United States)

^b EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^c GE PLASTICS   (United States)

^d Toxicology/Regulatory Services Inc   (United States)

^e Formerly Baver Material Science AG   (United States)

^f BAYER PHARMA AG   (Germany)

^g DOW CHEMICAL COMPANY   (United States)

^h AMERICAN CHEMISTRY COUNCIL   (United States)

Author keywords

17 estradiol; 2 generation reproductive toxicity study; Acquisition of puberty; Andrology; CD 1 mice; Estrous cyclicity; OECD 416

Indexed keywords

ESTRADIOL;

ANDROLOGY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FEMALE GENITAL SYSTEM; FERTILITY; HISTOPATHOLOGY; LACTATION; MALE; MALE GENITAL SYSTEM; MOUSE; NONHUMAN; PREGNANCY; REPRODUCTIVE TOXICITY; SWISS WEBSTER MOUSE;

ADMINISTRATION, ORAL; ANIMALS; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; ESTRADIOL; ESTROGENS; FEMALE; GENITALIA; LITTER SIZE; LONGEVITY; MALE; MATERNAL EXPOSURE; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; PATERNAL EXPOSURE; PREGNANCY; REPRODUCTION; SEXUAL MATURATION; VAGINA;

MUS;

EID: 40949118921     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn002     Document Type: Article

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