Effects of 17β-estradiol on serum hormone concentrations and estrous cycle in female Crl:CD BR rats: Effects on parental and first generation rats

Toxicological Sciences

Volumn 44, Issue 2, 1998, Pages 143-154

  Biegel, Lisa B ^a   Cook, Jon C ^a   Hurtt, Mark E ^a   O'Connor, John C ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL;

ANIMAL EXPERIMENT; ARTICLE; BIOASSAY; DISEASE SEVERITY; ESTRADIOL BLOOD LEVEL; ESTRUS CYCLE; FEMALE; NONHUMAN; PRENATAL EXPOSURE; PROGESTERONE BLOOD LEVEL; RAT; REPRODUCTIVE TOXICITY;

ANIMALIA; RODENTIA;

EID: 0031694202     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1006/toxs.1998.2469     Document Type: Article

References (29)

1. Allen, E., and Doisy, E. A. (1923). An ovarian hormone. Preliminary report on its localization, extraction and partial purification and action in test animals. JAMA 81, 819-821.
2. Allen, E., and Doisy, E. A. (1924). The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone. Am. J. Physiol. 69, 577-588.
3. Beach, J. E., Tyrey, L., Schomberg, D. W., and Everett, J. W. (1983). Nocturnal and diurnal levels of prolactin, LH, FSH, estrogens, and progesterone in middle-aged, spontaneously persistent estrous rats. Age 6, 82-85.
4. Biegel, L. B., Flaws, J. A., Hirschfield, A. N., O'Connor, J. C., Elliott, G., Ladics, G. S., Van Pelt, C., Hurtt, M. E., Cook, J. C., Silbergeld, E. K., and Frame, S. R. (1998). 90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17β-estradiol. Toxicol. Sci. 44, 116-142.
5. Blankenstein, M. A., Broerse, J. J., van Zwieten, M. J., and van der Molen, H. J. (1984). Prolactin concentration in plasma and susceptibility to mammary tumors in female rats from different strains treated chronically with estradiol-17β. Breast Cancer Treat. 4, 137-141.
6. Cook, J. C., Kaplan, A. M., Davis, L. G., and O'Connor, J. C. (1997). Development of a Tier I screening battery for detecting endocrine-active compounds. Regul. Toxicol. Pharmacol. 26, 60-68.
7. Elkind-Hirsch, K., King, J. C., Gerall, A. A., and Leeman, S. E. (1984). Neonatal estrogen affects preoptic/anterior hypothalamic LHRH differently in adult male and female rats. Neuroendocrinology 38, 68-74.
8. Everett, J. W. (1989). Neurobiology of Reproduction in the Female Rat: A Fifty-Year Perspective. Springer-Verlag, New York.
9. Faber, K. A., and Hughes, C. L., Jr. (1991). The effect of neonatal exposure to diethylstilbestrol, genistein, and zearalenone on pituitary responsiveness and sexually dimorphic nucleus volume in the castrated adult rat. Biol. Reprod. 45, 649-653.
10. Freeman, M. E. (1988). The ovarian cycle of the rat. In The Physiology of Reproduction (E. Knobil and J. Neill, Eds.), Chapter 45, pp. 1893-1928. Raven Press, New York.
11. Gray, L. E., Ostby, J., Ferrell, J., Rehnberg, G., Linder, R., Cooper, R., Goldman, J., Slott, V., and Laskey, J. (1989). A dose-response analysis of methoxychlor-induced alterations of reproductive development and function in the rat. Fundam. Appl. Toxicol. 12, 92-109.
12. Grosser, P. M., McCarthy, G. F., Rogaire, B., Farookhi, R., and Brawer, J. R. (1987). Plasma patterns of LH, FSH and prolactin in rats with a polycystic ovarian condition induced by oestradiol valerate. J. Endocrinol. 114, 33-39.
13. Harris, S. J., Cecil, H. C., and Bitman, J. (1974). Effect of several dietary levels of technical methoxychlor on reproduction in rats. J. Agric. Food Chem. 22, 969-973.
14. Heywood, R., and Wadsworth, P. F. (1980). The experimental toxicology of estrogens. Pharmacol. Ther. 8, 125-142.
15. Kelce, W. R., and Gray, Jr., L. E. (1996). Endocrine disrupters: Effects on sex steroid hormone receptors and sex development. In Drug Toxicity in Embryonic Development II (R. J. Kavlock and G. P. Daston, Eds.), Chapter 31, pp. 435-474. Springer-Verlag, New York.
16. Key, T., and Reeves, G. (1994). Organochlorines in the environment and breast cancer. Br. Med. J. 308, 1520-1521.
17. Krey, L. C. (1971). Estrogen Administration Early in the Rat Estrous Cycle: Feed Back Effects on Gonadotrophin Secretion, Dissertation. Duke University, Durham, NC.
18. Kuhnz, W., and Putz, B. (1989). Pharmacokinetic interpretation of toxicity tests in rats treated with oestradiol valerate in the diet. Pharmacol. Toxicol. 65, 217-222.
19. Laws, S. D., Ferrell, J. M., Goldman, J. M., and Cooper, R. L. (1998). Effects of 4-tert-octylpnenol and nonylphenol on estrous cyclicity in adult Long Evans rats. Toxicol. Sci. 42, 1-S 175.
20. LeFevre, J., and McClintock, M. K. (1988). Reproductive senescence in female rats: a longitudinal study of individual differences in estrous cycles and behavior. Biol. Reprod. 38, 780-789.
21. Long, J., and Evans, H. (1922). The oestrous cycling the rat and its associated phenomena. Mem. Univ. Calif. 6, 1-148.
22. Meites, J., Lu, K. H., Wuttke, W., Welsch, C. W., Nagasawa, H., and Quadri, S. K. (1972). Recent studies on functions and control of prolactin secretion in rats. Recent Prog. Horm. Res. 28, 471-479.
23. Montes, G. S., and Luque, E. H. (1988). Effects of ovarian steroids on vaginal smears in the rat. Acta Anat. 133, 192-199.
24. NTP (1997). Final Report on the Reproductive Toxicity of Nonylphenol: Administered by Gavage to Sprague-Dawley Rats, Technical Report, September 2, 1997, RACB94012. National Institute of Environmental Health Sciences, Bethesda, MD.
25. O'Connor, J. C., Cook, J. C., Craven, S. C., Van Pelt, C. S., and Obourn, J. C. (1996). An in vivo battery for characterizing endocrine modulators that are estrogenic or dopamine regulators. Fundam. Appl. Toxicol. 33, 182-195.
26. Peluso, J. J., Steger, R. W., and Hafez, E. S. E. (1997). Regulation of LH secretion in aged female rats. Biol. Reprod. 16, 212-215.
27. Reel, J. R., Lamb, J. C., IV, and Neal, B. H. (1996). Survey and assessment of mammalian estrogen biological assays for hazard characterization. Fundam. Appl. Toxicol. 34, 288-305.
28. Rodriguez, P., Fernandez-Galaz, C., and Tejero, A. (1993). Controlled neonatal exposure to estrogens: A suitable tool for reproductive aging studies in the female rat. Biol. Reprod. 49, 387-392.
29. Schulster, A., Farookhi, R., and Brawer, J. R. (1984). Polycystic ovarian condition in estradiol valerate-treated rats: Spontaneous changes in characteristic endocrine features. Biol. Reprod. 31, 587-593.