Novel 1,3,4-thiadiazolium-2-phenylamine chlorides derived from natural piperine as trypanocidal agents: Chemical and biological studies

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 2984-2991

  da Silva Ferreira, Welisson ^a   Freire de Lima, Leonardo ^b   Saraiva, Víctor Barbosa ^b   Alisson Silva, Frederico ^b   Mendonça Previato, Lucia ^b   Previato, José Osvaldo ^b   Echevarria, Aurea ^a   de Lima, Marco Edilson Freire ^a  

^a FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

1,3,4 Thiadiazolium 2 phenylamine; Chagas' disease; Mesoionic compounds; Piperine; Trypanosoma cruzi

Indexed keywords

4 PHENYL 5 (3,4 METHYLENEDIOXYPHENYL) 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 (6 NITRO 3,4 METHYLENEDIOXYPHENYL) 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 [2 (3,4 METHYLENEDIOXYPHENYL) (E)ETHENYL] 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 [2 (3,4 METHYLENEDIOXYPHENYL)BUTYL] 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 [2 (3,4 METHYLENEDIOXYPHENYL)ETHYL] 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 [2 (6 NITRO 3,4 METHYLENEDIOXYPHENYL) (E)ETHENYL] 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 [2 (6 NITRO 3,4 METHYLENEDIOXYPHENYL)BUTYL] 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 [2 (6 NITRO 3,4 METHYLENEDIOXYPHENYL)ETHYL] 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; 4 PHENYL 5 [4 (3,4 METHYLENEDIOXYPHENYL) 1(E) 3(E) BUTADIENYL] 1,3,4 THIADIAZOLIUM 2 PHENYLAMINE CHLORIDE; ANTITRYPANOSOMAL AGENT; CHLORIDE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HOST CELL; MACROPHAGE; NONHUMAN; TRYPANOSOMA CRUZI;

ALKALOIDS; ANIMALS; BENZODIOXOLES; CHAGAS DISEASE; MACROPHAGES; MICE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

MURINAE; TRYPANOSOMA CRUZI;

EID: 40949098614     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.12.049     Document Type: Article

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