Foxp3-expressing Regulatory T Cells Expanded With CD28 Superagonist Antibody Can Prevent Rat Cardiac Allograft Rejection

Journal of Heart and Lung Transplantation

Volumn 27, Issue 4, 2008, Pages 362-371

  Kitazawa, Yusuke ^a,g   Fujino, Masayuki ^a,b   Sakai, Takatoshi ^c   Azuma, Haruhito ^d   Kimura, Hiromitsu ^a   Isaka, Yoshitaka ^e   Takahara, Shiro ^e   Hünig, Thomas ^f   Abe, Ryo ^g   Li, Xiao Kang ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c Shizuoka Laboratory Animal Center Ltd   (Japan)

^d OSAKA MEDICAL COLLEGE   (Japan)

^e OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f UNIVERSITY OF WÜRZBURG   (Germany)

^g TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; MONOCLONAL ANTIBODY CD28; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CARDIAC GRAFT REJECTION; CD4+ CD25+ T LYMPHOCYTE; CELL POLARITY; CONTROLLED STUDY; CORRELATION ANALYSIS; GRAFT SURVIVAL; HEART TRANSPLANTATION; IN VIVO STUDY; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURIFICATION; RAT; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH2 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; BLOOD CELLS; CELL PROLIFERATION; CONCANAVALIN A; FORKHEAD TRANSCRIPTION FACTORS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKINS; ISOANTIGENS; MALE; MYOCARDIUM; POSTOPERATIVE PERIOD; RATS; RATS, INBRED STRAINS; T-LYMPHOCYTES, REGULATORY; TIME FACTORS; TRANSPLANTATION, HETEROTOPIC;

EID: 40949094813     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2008.01.004     Document Type: Article

References (28)

1. Asano M., Toda M., Sakaguchi N., and Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med 184 (1996) 387-396
2. Hara M., Kingsley C.I., Niimi M., et al. IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J Immunol 166 (2001) 3789-3796
3. Chiffoleau E., Beriou G., Dutartre P., et al. Role for thymic and splenic regulatory CD4+ T cells induced by donor dendritic cells in allograft tolerance by LF15-0195 treatment. J Immunol 168 (2002) 5058-5069
4. Guo L., Fujino M., Kimura H., et al. Simultaneous blockade of co-stimulatory signals, CD28 and ICOS, induced a stable tolerance in rat heart transplantation. Transplant Immunol 12 (2003) 41-48
5. Tacke M., Hanke G., Hanke T., and Hunig T. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur J Immunol 27 (1997) 239-247
6. Lin C.H., and Hunig T. Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. Eur J Immunol 33 (2003) 626-638
7. Luhder F., Huang Y., Dennehy K.M., et al. Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. J Exp Med 197 (2003) 955-966
8. Rodriguez-Palmero M., Hara T., Thumbs A., and Hunig T. Triggering of T cell proliferation through CD28 induces GATA-3 and promotes T helper type 2 differentiation in vitro and in vivo. Eur J Immunol 29 (1999) 3914-3924
9. Schmidt J., Elflein K., Stienekemeier M., et al. Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies. J Neuroimmunol 140 (2003) 143-152
10. Rodriguez-Palmero M., Franch A., Castell M., et al. Effective treatment of adjuvant arthritis with a stimulatory CD28-specific monoclonal antibody. J Rheumatol 33 (2006) 110-118
11. Beaudette-Zlatanova B.C., Whalen B., Zipris D., et al. Costimulation and autoimmune diabetes in BB rats. Am J Transplant 6 (2006) 894-902
12. Wells A.D., Gudmundsdottir H., and Turka L.A. Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J Clin Invest 100 (1997) 3173-3183
13. Funeshima N., Fujino M., Kitazawa Y., et al. Inhibition of allogeneic T-cell responses by dendritic cells expressing transduced indoleamine 2,3-dioxygenase. J Gene Med 7 (2005) 565-575
14. Kitazawa Y., Fujino M., Wang Q., et al. Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-cell activity to suppress alloimmune responses. Transplantation 83 (2007) 774-782
15. Fujino M., Kitazawa Y., Kawasaki M., et al. Differences in lymphocyte gene expression between tolerant and syngeneic liver grafted rats. Liver Transplant 10 (2004) 379-391
16. Fujino M., Li X.K., Funeshima N., et al. Exogenous gene expression by Cre/loxP-mediated switching system containing adenovirus vector in mouse. [in Japanese with English abstract]. Organ Biol 5 (1998) 45-52
17. Hori S., Nomura T., and Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299 (2003) 1057-1061
18. Beyersdorf N., Balbach K., Hunig T., and Kerkau T. Large-scale expansion of rat CD+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation. Immunology 119 (2006) 441-450
19. Kretschmer K., Apostolou I., Hawiger D., et al. Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 6 (2005) 1219-1227
20. Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4 (2004) 665-674
21. Zhang H., Chua K.S., Guimond M., et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med 11 (2005) 1238-1243
22. Setoguchi R., Hori S., Takahashi T., and Sakaguchi S. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med 201 (2005) 723-735
23. Guo L., Fujino M., Kimura H., et al. AdCTLA-4Ig combined with donor splenocytes, bone marrow cells and anti-ICOS antibody treatment induce tolerance in a rat heart transplantation model. Transplant Int 17 (2004) 15-21
24. Hofmann B., Tao K., Mai L., and West L.J. Acceptance of related and unrelated cardiac allografts in neonatally tolerized mice is cardio-specific and transferable by regulatory CD4+ T cells. J Heart Lung Transplant 23 (2004) 1069-1076
25. Watanabe M., Mencel R.L., Cramer D.V., Starnes V.A., and Barr M.L. Transforming growth factor-beta/interleukin-2-induced regulatory CD4+ T cells prolong cardiac allograft survival in rats. J Heart Lung Transplant 24 (2005) 2153-2159
26. Graca L., Cobbold S.P., and Waldmann H. Identification of regulatory T cells in tolerated allografts. J Exp Med 195 (2002) 1641-1646
27. Lee I., Wang L., Wells A.D., Dorf M.E., Ozkaynak E., and Hancock W.W. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 201 (2005) 1037-1044
28. Suntharalingam G., Perry M.R., Ward S., et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 355 (2006) 1018-1028