A topological study of the human γ-glutamyl carboxylase

Blood

Volumn 96, Issue 3, 2000, Pages 973-978

  Tie, J ^a   Wu, S M ^a   Jin, D ^a   Nicchitta, C V ^a   Stafford, D W ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENDOPLASMIC RETICULUM; ENZYME ANALYSIS; ENZYME DEGRADATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MEMBRANE STRUCTURE; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA TRANSLATION;

EID: 0034254613     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.3.973     Document Type: Article

References (44)

1. The submicrosomal site for the conversion of prothrombin precursor to biologically active prothrombin in rat liver
2. Identification and purification to near homogeneity of the vitamin K- dependent carboxylase
3. Cloning and expression of the cDNA for human gamma-glutamyl carboxylase
4. Substrate recognition by the vitamin K-dependent gamma-glutamyl carboxylase: Identification of a sequence homology between the carboxylase and the carboxylase recognition site in the substrate
5. Localization of the affinity peptide-substrate inactivator site on recombinant vitamin K-dependent carboxylase
6. The active site region of the vitamin K-dependent carboxylase includes both the amino-terminal hydrophobic and carboxy-terminal hydrophilic domains of the protein
7. Localization of the factor IX propeptide binding site on recombinant vitamin K dependent carboxylase using benzoylphenylalanine photoaffinity peptide inactivators
8. The propeptide binding site of the bovine gamma-glutamyl carboxylase
9. Profactor IX propeptide and glutamate substrate binding sites on the vitamin K-dependent carboxylase identified by site-directed mutagenesis
10. Vitamin K-dependent oxygenase/carboxylase: Differential inactivation by sulfhydryl reagents
11. Amino-terminal assembly of human P-glycoprotein at the endoptasmic reticulum is directed by cooperative actions of two internal sequences
12. Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation
13. Co- and posttranslational translocation mechanisms direct cystic fibrosis transmembrane conductance regulator N terminus transmembrahe assembly
14. Membrane topology and biogenesis of eukaryotic signal peptidase
15. Evidence for a six-transmembrane domain structure of presenilin 1
16. Topological rules for membrane protein assembly in eukaryotic cells
17. Rapid and efficient site-specific mutagenesis without phenotypic selection
18. Preparation of microsomal membranes for cotranslational protein translocation
19. A new technique for the assay of infectivity of human adenovirus 5 DNA
20. Propeptide and glutamate-containing substrates bound to the vitamin K- dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state
21. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
22. The reliability of molecular weight determinations by dodecyl sulfate- polyacrylamide gel electrophoresis
23. Membrane protein structure prediction: Hydrophobicity analysis and the positive-inside rule
24. Membrane proteins: From sequence to structure
25. Determination of the distance between the oligosaccharyitransferase active site and the endoplasmic reticulum membrane
26. Positively charged amino acids placed next to a signal sequence block protein translocation more efficiently in Escherichia coli than in mammalian microsomes
27. Intracellular protein topogenesis
28. Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence
29. Predicting the orientation of eukaryotic membrane-spanning proteins
30. Topology profile for a glutamate receptor: Three transmembrane domains and a channel-lining reentrant membrane loop
31. Expression of fusion proteins of the nicotinic acetylcholine receptor from mammalian muscle identifies the membranespanning regions in the alpha and delta subunits
32. Structural requirements for membrane assembly of proteins spanning the membrane several times
33. Multiple determinants direct the orientation of signal-anchor proteins: The topogenic role of the hydrophobic signal domain
34. Heads or tails: What determines the orientation of proteins in the membrane
35. Transmembrahe orientation of signal-anchor proteins is affected by the folding state but not the size of the N-terminal domain
36. Artificial transmembrane segments: Requirements for stop transfer and polypeptide orientation
37. Reversible topology of a bifunctional transmembrahe protein depends upon the charge balance around its transmembrane domain
38. Coupled translocation events generate topological heterogeneity at the endoplasmic reticulum membrane
39. Topological determinants of internal transmembrane segments in P- glycoprotein sequences
40. Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1)
41. Membrane proteins which exhibit multiple topological orientations
42. Vitamin K dependent carboxylase: Subcellular location of the carboxylase and enzymes involved in vitamin K metabolism in rat liver
43. Vitamin K and energy transduction: A base strength amplification mechanism