New insights into testicular germ cell tumorigenesis from gene expression profiling

Cancer Research

Volumn 62, Issue 8, 2002, Pages 2359-2364

  Skotheim, Rolf I ^a   Monni, Outi ^b,c   Mousses, Spyro ^c   Fosså, Sophie D ^a   Kallioniemi, Olli P ^c   Lothe, Ragnhild A ^a   Kallioniemi, Anne ^c,d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b BIOMEDICUM HELSINKI   (Finland)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF TAMPERE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; PLAKOGLOBIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CARCINOMA IN SITU; CHROMOSOME 17Q; CLUSTER ANALYSIS; CONTROLLED STUDY; DNA MICROARRAY; EXPRESSED SEQUENCE TAG; GENE EXPRESSION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENE TARGETING; GENETIC ANALYSIS; GERM CELL TUMOR; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTO ONCOGENE; SEMINOMA; TESTIS;

CHROMOSOMES, HUMAN, PAIR 17; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GERMINOMA; HUMANS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; TESTICULAR NEOPLASMS; UP-REGULATION;

EID: 0037089555     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Increase in testicular cancer incidence in six European countries: A birth cohort phenomenon
2. Recent cancer trends in the United States
3. Carcinoma in situ of the testis: Review of biological and clinical features
4. Specific chromosome change, i(12p), in testicular tumours?
5. Molecular cytogenetic analysis of i(12p)-negative human male germ cell tumors
6. Genetics and biology of adult human male germ cell tumors
7. Pathogenesis of testicular germ cell tumours
8. Genome profiles of familial/bilateral and sporadic testicular germ cell tumors
9. Gain of 17q24-qter detected by comparative genomic hybridization in malignant tumors from patients with von Recklinghausen's neurofibromatosis
10. Comparative genomic hybridization analysis of 38 breast cancer cell lines: A basis for interpreting complementary DNA microarray data
11. 17q12-21 amplicon, a novel recurrent genetic change in intestinal type of gastric carcinoma: A comparative genomic hybridization study
12. Comparative genomic hybridization study of primary neuroblastoma tumors
13. Molecular cytogenetic fingerprinting of esophageal squamous cell carcinoma by comparative genomic hybridization reveals a consistent pattern of chromosomal alterations
14. Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer
15. Ratio-based decisions and the quantitative analysis of cDNA microarray images
16. Gene expression analysis by cDNA microarrays
17. Cytogenetics of male germ-cell tumors
18. Chromosomal gains and losses in testicular germ cell tumors of adolescents and adults investigated by a modified comparative genomic hybridization approach
19. The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancer
20. New amplified and highly expressed genes discovered in the ERBB2 amplicon in breast cancer by cDNA microarrays
21. Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma
22. Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method
23. Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor
24. Grb7 is a downstream signaling component of platelet-derived growth factor α- and β-receptors
25. Direct association between the Ret receptor tyrosine kinase and the Src homology 2-containing adapter protein Grb7
26. Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH 2
27. Association of focal adhesion kinase with Grb7 and its role in cell migration
28. Use of the two hybrid system to detect the association of the protein-tyrosine-phosphatase, SHPTP2, with another SH2-containing protein, Grb7
29. Expression of the c-kit proto-oncogene and its ligand stem cell factor (SCF) in normal and malignant human testicular tissue
30. Stem cell factor/c-kit system in spermatogenesis
31. Sequence analysis identifies a ras-associating (RA)-like domain in the N-termini of band 4.1/JEF domains and in the Grb7/10/14 adapter family
32. Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration
33. C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development
34. Grb7 signal transduction protein mediates metastatic progression of esophageal carcinoma
35. γ-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin
36. Catenins, Wnt signaling and cancer
37. The I(2)gl homologue of Drosophila pseudoobscura suppresses tumorigenicity in transgenic Drosophila melanogaster
38. Requirement of Drosophila I(2)gl function for survival of the germline cells and organization of the follicle cells in a columnar epithelium during oogenesis
39. Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase α-subunit and chromosomal localization of the human gene
40. Differential expression of protooncogenes in human germ cell tumors of the testis
41. MYCN amplification and 17q in neuroblastoma: Evidence for structural association
42. Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression
43. Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis
44. Activated ras genes in human seminoma: Evidence for tumor heterogeneity
45. K-ras oncogene codon 12 point mutations in testicular cancer
46. Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis
47. D-type cyclins in adult human testis and testicular cancer: Relation to cell type, proliferation, differentiation, and malignancy
48. cDNA sequencing and analysis of POV1 (PB39): A novel gene up-regulated in prostate cancer
49. Mxil, a protein that specifically interacts with Max to bind Myc-Max recognition sites
50. DNA pooling as a quick method for finding candidate linkages in multigenic trait analysis: An example involving susceptibility to germ cell tumors
51. Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain
52. Commonly occurring loss and mutation of the MX11 gene in prostate cancer
53. DNA methylation, methyltransferases, and cancer
54. DNA methyl-transferase expression and DNA methylation of CpG islands and peri-centromeric satellite regions in human colorectal and stomach cancers
55. Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis