Reactive Oxygen Species, Diabetes and Toxicity in the Placenta - A Workshop Report

Placenta

Volumn 29, Issue SUPPL., 2008, Pages 105-107

  Foster, W ^a   Myllynen, P ^b   Winn, L M ^c   Ornoy, A ^d   Miller, R K ^e  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF OULU   (Finland)

^c QUEEN S UNIVERSITY   (Canada)

^d HEBREW UNIVERSITY   (Israel)

^e UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Cytochrome P450; Diabetes; Neural tube defects; Placenta; Reactive oxygen species; Toxicology

Indexed keywords

ANTICONVULSIVE AGENT; BENZENE; BENZO(ALPHA)PYRENE; BREAST CANCER RESISTANCE PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 3A4; DNA; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PHENYTOIN; PYRENE DERIVATIVE; REACTIVE OXYGEN METABOLITE; RETINOID DERIVATIVE; THALIDOMIDE; UNCLASSIFIED DRUG; VALPROIC ACID; XENOBIOTIC AGENT;

ARTICLE; BIRTH DEFECT; CLINICAL FEATURE; CONGENITAL MALFORMATION; DNA ADDUCT; DNA RECOMBINATION; DRUG MECHANISM; DRUG TRANSPORT; ENZYME ACTIVITY; ENZYME METABOLISM; HUMAN; NEOPLASM; NEURAL TUBE DEFECT; NONHUMAN; OXIDATIVE STRESS; PERINATAL PERIOD; PLACENTA FUNCTION; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TERATOGENESIS;

CONGENITAL ABNORMALITIES; CYTOCHROME P-450 ENZYME SYSTEM; DIABETES, GESTATIONAL; EDUCATION; FEMALE; HUMANS; PLACENTA; PREGNANCY; REACTIVE OXYGEN SPECIES;

EID: 40849141945     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2007.10.014     Document Type: Article

References (10)

1. Miller R.K. Does the placenta protect against insult or is it the target?. Teratology primer (2005)
2. Myllynen P., Pasanen M., and Pelkonen O. Human placenta: a human organ for developmental toxicology research and biomonitoring. Placenta 26 5 (2005) 361-371
3. Myllynen P., Pasanen M., and Vähäkangas K. The fate and effects of xenobiotics in human placenta. Expert Opin Drug Metab Toxicol 3 (2007) 331-346
4. Wan J., and Winn L.M. In utero-initiated cancer: the role of reactive oxygen species. Birth Defects Res C Embryo Today 78 (2006) 326-332
5. Dawson J.E., Raymond A.M., and Winn L.M. Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. Toxicol Appl Pharmacol 211 (2006) 124-132
6. Thadani N.A., McNamee J.P., and Winn L.M. Thalidomide alters c-Myb and Pim-1 signaling in K-563 cells. Pharmacol Res 54 (2006) 91-96
7. Winn L.M. Homologous recombination initiated by benzene metabolites: a potential role of oxidative stress. Toxicol Sci 72 (2003) 143-149
8. Winn L.M., Kim P.M., and Nickoloff J.A. Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity. J Pharmacol Exp Ther 306 (2003) 523-527
9. Defoort E.N., Kim P.M., and Winn L.M. Valproic acid increases conservative homologous recombination frequency and reactive oxygen species formation: a potential mechanism for valproic acid-induced neural tube defects. Mol Pharmacol 69 (2006) 1304-1310
10. Zangen W.S., Seonghun R., and Ornoy A. The role of antioxidant enzymes and transcription factor NF-kappa B in diabetic embryopathy in the Cohen diabetic rat model. Birth Defects Res A Clin Mol Teratol 76 (2006) 107-114