An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor

FEBS Letters

Volumn 582, Issue 7, 2008, Pages 1141-1146

  Bifulco, Katia ^a   Longanesi Cattani, Immacolata ^a   Gargiulo, Lucia ^a   Maglio, Ornella ^b   Cataldi, Mauro ^b   De Rosa, Mario ^c   Stoppelli, Maria Patrizia ^d   Pavone, Vincenzo ^b   Carriero, Maria Vincenza ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

Formyl peptide receptor; Inhibitors of Cell Migration; Urokinase receptor

Indexed keywords

FORMYLPEPTIDE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEPTIDE; PYROGLUTAMYLARGINYLGLUTAMYLARGINYLTYROSINAMIDE; RECEPTOR BLOCKING AGENT; SERYLARGINYLSERYLARGINYLTYROSINE; UNCLASSIFIED DRUG; UROKINASE RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CHEMOTAXIS; HUMANS; OLIGOPEPTIDES; PEPTIDES; RATS; RECEPTORS, CELL SURFACE; RECEPTORS, FORMYL PEPTIDE; SIGNAL TRANSDUCTION;

EID: 40849140607     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.03.001     Document Type: Article

References (26)

1. Pantel K., and Brakenhoff R.H. Dissecting the metastatic cascade. Nat. Rev. Cancer 4 (2004) 448-456
2. Chabner B.A., and Roberts Jr. T.G. Timeline: chemotherapy and the war on cancer. Nat. Rev. Cancer 5 (2005) 65-72
3. Blasi F., and Carmeliet P. uPAR: a versatile signaling orchestrator. Nat. Rev. Mol. Biol. 3 (2002) 932-943
4. Danø K., Behrendt N., Høyer-Hansen G., Johnsen M., Lund L.R., Ploug M., and Rømer J. Plasminogen activation and cancer. Thromb. Haemostasis 93 (2005) 676-681
5. Carriero M.V., Del Vecchio S., Capozzoli M., Franco P., Fontana L., Zannetti A., Botti G., D'Aiuto G., Salvatore M., and Stoppelli M.P. Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer. Cancer Res. 59 (1999) 5307-5314
6. Ossowski L., and Aguirre-Ghiso J.A. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Curr. Opin. Cell Biol. 12 (2000) 613-620
7. Cunningham O., Andolfo A., Santovito M.L., Iuzzolino L., Blasi F., and Sidenius N. Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions. EMBO J. 22 (2003) 5994-6003
8. Alfano D., Franco P., Vocca I., Gambi N., Pisa V., Mancini A., Caputi M., Carriero M.V., Iaccarino I., and Stoppelli M.P. The urokinase plasminogen activator and its receptor: role in cell growth and apoptosis. Thromb. Haemostasis 93 (2005) 205-211
9. Llinas P., Le Du M.H., Gardsvoll H., Dano K., Ploug M., Gilquin B., Stura E.A., and Menez A. Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide. EMBO J. 24 (2005) 1655-1663
10. Barinka C., Parry G., Callahan J., Shaw D.E., Kuo A., Bdeir K., Cines D.B., Mazar A., and Lubkowski J. Structural basis of interaction between urokinase-type plasminogen activator and its receptor. J. Mol. Biol. 363 (2006) 482-495
11. Trigwell S., Wood L., and Jones P. Soluble urokinase receptor promotes cell adhesion and requires tyrosine-92 for activation of p56/59 (hck). Biochem. Biophys. Res. Commun. 278 (2000) 440-446
12. Gargiulo L., Longanesi-Cattani I., Bifulco K., Franco P., Raiola R., Campiglia P., Greco P., Peluso G., Stoppelli M.P., and Carriero M.V. Cross-talk between fMLP and vitronectin receptors triggered by urokinase receptor-derived SRSRY peptide. J. Biol. Chem. 280 (2005) 25225-25232
13. Resnati M., Pallavicini I., Wang J.M., Oppenheim J.J., Serhan C.N., Romano M., and Blasi F. The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. Proc. Natl. Acad. Sci. USA 99 (2002) 1359-1364
14. Montuori N., Carriero M.V., Salzano S., Rossi G., and Ragno P. The cleavage of the urokinase receptor regulates its multiple functions. J. Biol. Chem. 277 (2002) 46932-46939
15. Stewart J.M., and Young J.D. Solid Phase Peptide Synthesis. second ed. (1984), Pierce Chemical Company, Rockford
16. Le Y., Gong W., Tiffany H.L., Tumanov A., Nedospasov S., Shen W., Dunlop N.M., Gao J.L., Murphy P.M., Oppenheim J.J., and Wang J.M. Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1. J. Neurosci. 21 (2001) RC123
17. Franco P., Vocca I., Carriero M.V., Alfano D., Cito L., Longanesi-Cattani I., Grieco P., Ossowski L., and Stoppelli M.P. Activation of urokinase receptor by a novel interaction between the connecting peptide region of urokinase and alpha v beta 5 integrin. J. Cell Sci. 119 (2006) 3424-3434
18. Carriero M.V., Del Vecchio S., Franco P., Potena M.I., Chiaradonna F., Botti G., Stoppelli M.P., and Salvatore M. Vitronectin binding to urokinase receptor in human breast cancer. Clin. Cancer Res. 3 (1997) 1289-1308
19. Perez D.M., and Karnik S.S. Multiple signaling states of G-protein-coupled receptors. Pharmacol. Rev. 57 (2005) 147-161
20. Bennett T.A., Maestas D.C., and Prossnitz E.R. Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence. J. Biol. Chem. 275 (2000) 24590-24594
21. Duffy M.J. The urokinase plasminogen activator system: role in malignancy. Curr. Pharm. Des. 10 (2004) 39-49
22. Degryse B., Resnati M., Czekay R.P., Loskutoff D.J., and Blasi F. Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. J. Biol. Chem. 280 (2005) 24792-24803
23. Bae Y.S., Song J.Y., Kim Y., He R., Ye R.D., Kwak J.Y., Suh P.G., and Ryu S.H. Differential activation of formyl peptide receptor signaling by peptide ligands. Mol. Pharmacol. 64 (2003) 841-847
24. Yan P., Nanamori M., Sun M., Zhou C., Cheng N., Li N., Zheng W., Xiao L., Xie X., Ye R.D., and Wang M.W. The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J. Immunol. 177 (2006) 7050-7058
25. Bae Y.S., Lee H.Y., Jo E.J., Kim J.I., Kang H.K., Ye R.D., Kwak J.Y., and Ryu S.H. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J. Immunol. 173 (2004) 607-614
26. Dorsam R.T., and Gutkind J.S. G-protein-coupled receptors and cancer. Nat. Rev. Cancer 7 (2007) 79-94