-
2
-
-
0040699988
-
Intestinal transport of beta-lactam antibiotics: Analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux
-
Bretschneider B., Brandsch M., Neubert R. Intestinal transport of beta-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm. Res. (1999) 16 55 61.
-
(1999)
Pharm. Res.
, vol.16
, pp. 55-61
-
-
Bretschneider, B.1
Brandsch, M.2
Neubert, R.3
-
3
-
-
0036710840
-
Mammalian peptide transporters as targets for drug delivery
-
Rubio-Aliaga I., Daniel H. Mammalian peptide transporters as targets for drug delivery. Trends Pharmacol. Sci. (2002) 23 434 440.
-
(2002)
Trends Pharmacol. Sci.
, vol.23
, pp. 434-440
-
-
Rubio-Aliaga, I.1
Daniel, H.2
-
4
-
-
34547169521
-
Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines
-
Hilgendorf C., Ahlin G., Seithel A., Artursson P., Ungell A.L., Karlsson J. Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines. Drug Metab. Dispos. (2007) 35 1333 1340.
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 1333-1340
-
-
Hilgendorf, C.1
Ahlin, G.2
Seithel, A.3
Artursson, P.4
Ungell, A.L.5
Karlsson, J.6
-
5
-
-
34548203927
-
Comparative gene expression profiles of intestinal transporters in mice, rats and humans
-
Kim H.R., Park S.W., Cho H.J. et al. Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacol. Res. (2007) 56 224 236.
-
(2007)
Pharmacol. Res.
, vol.56
, pp. 224-236
-
-
Kim, H.R.1
Park, S.W.2
Cho, H.J.3
-
6
-
-
0021025978
-
Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with l-carnosine and glycyl-l-proline
-
Ganapathy V., Leibach F.H. Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with l-carnosine and glycyl-l-proline. J. Biol. Chem. (1983) 258 14189 14192.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 14189-14192
-
-
Ganapathy, V.1
Leibach, F.H.2
-
7
-
-
0022106251
-
Is intestinal peptide transport energized by a proton gradient?
-
Ganapathy V, Leibach F.H. Is intestinal peptide transport energized by a proton gradient? Am. J. Physiol. (1985) 249 G153 G160.
-
(1985)
Am. J. Physiol.
, vol.249
-
-
Ganapathy, V.1
Leibach, F.H.2
-
9
-
-
0030964451
-
Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2)
-
Brandsch M., Brandsch C., Ganapathy M.E., Chew C.S., Ganapathy V., Leibach F.H. Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2). Biochim. Biophys. Acta (1997) 1324 251 262.
-
(1997)
Biochim. Biophys. Acta
, vol.1324
, pp. 251-262
-
-
Brandsch, M.1
Brandsch, C.2
Ganapathy, M.E.3
Chew, C.S.4
Ganapathy, V.5
Leibach, F.H.6
-
10
-
-
0032723028
-
H(+)/solute-induced intracellular acidification leads to selective activation of apical Na(+)/H(+) exchange in human intestinal epithelial cells
-
Thwaites D.T., Ford D., Glanville M., Simmons N.L. H(+)/solute-induced intracellular acidification leads to selective activation of apical Na(+)/H(+) exchange in human intestinal epithelial cells. J. Clin. Invest. (1999) 104 629 635.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 629-635
-
-
Thwaites, D.T.1
Ford, D.2
Glanville, M.3
Simmons, N.L.4
-
11
-
-
0031786518
-
Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats
-
Chiou W.L., Barve A. Linear correlation of the fraction of oral dose absorbed of 64 drugs between humans and rats. Pharm. Res. (1998) 15 1792 1795.
-
(1998)
Pharm. Res.
, vol.15
, pp. 1792-1795
-
-
Chiou, W.L.1
Barve, A.2
-
12
-
-
10644245087
-
Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs
-
Nagahara N., Tavelin S., Artursson P. Contribution of the paracellular route to the pH-dependent epithelial permeability to cationic drugs. J. Pharm. Sci. (2004) 93 2972 2984.
-
(2004)
J. Pharm. Sci.
, vol.93
, pp. 2972-2984
-
-
Nagahara, N.1
Tavelin, S.2
Artursson, P.3
-
13
-
-
0037308398
-
A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes
-
Tsutsumi K., Li S.K., Ghanem A.H., Ho N.F., Higuchi W.I. A systematic examination of the in vitro Ussing chamber and the in situ single-pass perfusion model systems in rat ileum permeation of model solutes. J. Pharm. Sci. (2003) 92 344 359.
-
(2003)
J. Pharm. Sci.
, vol.92
, pp. 344-359
-
-
Tsutsumi, K.1
Li, S.K.2
Ghanem, A.H.3
Ho, N.F.4
Higuchi, W.I.5
-
14
-
-
0029859233
-
The relationship between rat intestinal permeability and hydrophilic probe size
-
Lane M.E., O'Driscoll C.M., Corrigan O.I. The relationship between rat intestinal permeability and hydrophilic probe size. Pharm. Res. (1996) 13 1554 1558.
-
(1996)
Pharm. Res.
, vol.13
, pp. 1554-1558
-
-
Lane, M.E.1
O'Driscoll, C.M.2
Corrigan, O.I.3
-
15
-
-
0028785264
-
Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs
-
Erickson R.H., Gum J.R. Jr., Lindström M.M., McKean D., Kim Y.S. Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs. Biochem. Biophys. Res. Commun. (1995) 216 249 257.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.216
, pp. 249-257
-
-
Erickson, R.H.1
Gum Jr., J.R.2
Lindström, M.M.3
McKean, D.4
Kim, Y.S.5
-
16
-
-
0000592382
-
The improved everted gut sac: A simple method to study intestinal P-glycoprotein
-
Barthe L., Bessouet M., Woodley J.F., Houin G. The improved everted gut sac: a simple method to study intestinal P-glycoprotein. Int. J. Pharm. (1998) 173 255 258.
-
(1998)
Int. J. Pharm.
, vol.173
, pp. 255-258
-
-
Barthe, L.1
Bessouet, M.2
Woodley, J.F.3
Houin, G.4
-
17
-
-
0031659639
-
An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine
-
Barthe L., Woodley J.F., Kenworthy S., Houin G. An improved everted gut sac as a simple and accurate technique to measure paracellular transport across the small intestine. Eur. J. Drug Metab. Pharmacokinet. (1998) 23 313 323.
-
(1998)
Eur. J. Drug Metab. Pharmacokinet.
, vol.23
, pp. 313-323
-
-
Barthe, L.1
Woodley, J.F.2
Kenworthy, S.3
Houin, G.4
-
19
-
-
0020669405
-
Determination of total protein
-
Peterson G.L. Determination of total protein. Meth. Enzymol. (1986) 91 95 119.
-
(1986)
Meth. Enzymol.
, vol.91
, pp. 95-119
-
-
Peterson, G.L.1
-
20
-
-
34249905437
-
Regulation of the oligopeptide transporter, PEPT-1, in DSS-induced rat colitis
-
Radeva G., Buyse M., Hindlet P. et al. Regulation of the oligopeptide transporter, PEPT-1, in DSS-induced rat colitis. Dig. Dis. Sci. (2007) 52 1653 1661.
-
(2007)
Dig. Dis. Sci.
, vol.52
, pp. 1653-1661
-
-
Radeva, G.1
Buyse, M.2
Hindlet, P.3
-
21
-
-
0033165880
-
Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models
-
Meaney C., O'Driscoll C. Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models. Eur. J. Pharm. Sci. (1999) 8 167 175.
-
(1999)
Eur. J. Pharm. Sci.
, vol.8
, pp. 167-175
-
-
Meaney, C.1
O'Driscoll, C.2
-
22
-
-
0023195566
-
Effects of diclofenac sodium and disodium ethylenediaminetetraacetate on electrical parameters of the mucosal membrane and their relation to the permeability enhancing effects in the rat jejunum
-
Yamashita S., Saitoh H., Nakanishi K., Masada M., Nadai T., Kimura T. Effects of diclofenac sodium and disodium ethylenediaminetetraacetate on electrical parameters of the mucosal membrane and their relation to the permeability enhancing effects in the rat jejunum. J. Pharm. Pharmacol. (1987) 39 621 626.
-
(1987)
J. Pharm. Pharmacol.
, vol.39
, pp. 621-626
-
-
Yamashita, S.1
Saitoh, H.2
Nakanishi, K.3
Masada, M.4
Nadai, T.5
Kimura, T.6
-
23
-
-
0026672499
-
Characterization of the oral absorption of several aminopenicillins: Determination of intrinsic membrane absorption parameters in the rat intestine in situ
-
Oh D.M., Sinko P.J., Amidon G.L. Characterization of the oral absorption of several aminopenicillins: determination of intrinsic membrane absorption parameters in the rat intestine in situ. Int. J. Pharm. (1992) 85 181 187.
-
(1992)
Int. J. Pharm.
, vol.85
, pp. 181-187
-
-
Oh, D.M.1
Sinko, P.J.2
Amidon, G.L.3
-
24
-
-
0037530341
-
Di/tri-peptide transporters as drug delivery targets: Regulation of transport under physiological and patho-physiological conditions
-
Nielsen C.U., Brodin B. Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions. Curr. Drug Targets (2003) 4 373 388.
-
(2003)
Curr. Drug Targets
, vol.4
, pp. 373-388
-
-
Nielsen, C.U.1
Brodin, B.2
-
25
-
-
0033278620
-
Gastrointestinal absorption of drugs: Methods and studies
-
Barthe L., Woodley J., Houin G. Gastrointestinal absorption of drugs: methods and studies. Fundam. Clin. Pharmacol. (1999) 13 154 168.
-
(1999)
Fundam. Clin. Pharmacol.
, vol.13
, pp. 154-168
-
-
Barthe, L.1
Woodley, J.2
Houin, G.3
-
26
-
-
9644287793
-
Localisation of drug permeability along the rat small intestine, using markers of the paracellular, transcellular and some transporter routes
-
Lacombe O., Woodley J., Solleux C., Delbos J.M., Boursier-Neyret C., Houin G. Localisation of drug permeability along the rat small intestine, using markers of the paracellular, transcellular and some transporter routes. Eur. J. Pharm. Sci. (2004) 23 385 391.
-
(2004)
Eur. J. Pharm. Sci.
, vol.23
, pp. 385-391
-
-
Lacombe, O.1
Woodley, J.2
Solleux, C.3
Delbos, J.M.4
Boursier-Neyret, C.5
Houin, G.6
-
27
-
-
0031589535
-
Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1
-
Saito H., Motohashi H., Mukai M., Inui K. Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1. Biochem. Biophys. Res. Commun. (1997) 237 577 582.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.237
, pp. 577-582
-
-
Saito, H.1
Motohashi, H.2
Mukai, M.3
Inui, K.4
-
28
-
-
0027529451
-
Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes
-
Thwaites D.T., Brown C.D., Hirst B.H., Simmons N.L. Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes. J. Biol. Chem. (1993) 268 7640 7642.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 7640-7642
-
-
Thwaites, D.T.1
Brown, C.D.2
Hirst, B.H.3
Simmons, N.L.4
-
29
-
-
0020613211
-
Determination of acid surface pH in vivo in rat proximal jejunum
-
Lucas M. Determination of acid surface pH in vivo in rat proximal jejunum. Gut (1983) 24 734 739.
-
(1983)
Gut
, vol.24
, pp. 734-739
-
-
Lucas, M.1
-
30
-
-
0023546214
-
Factors affecting the microclimate pH in rat jejunum
-
Shimada T. Factors affecting the microclimate pH in rat jejunum. J. Physiol. (1987) 392 113 127.
-
(1987)
J. Physiol.
, vol.392
, pp. 113-127
-
-
Shimada, T.1
-
31
-
-
0020540853
-
Drug absorption by the rat jejunum perfused in situ. Dissociation from the pH-partition theory and role of microclimate-pH and unstirred layer
-
Hogerle M.L., Winne D. Drug absorption by the rat jejunum perfused in situ. Dissociation from the pH-partition theory and role of microclimate-pH and unstirred layer. Naunyn Schmiedebergs Arch. Pharmacol. (1983) 322 249 255.
-
(1983)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.322
, pp. 249-255
-
-
Hogerle, M.L.1
Winne, D.2
-
32
-
-
0022550364
-
PH-microclimate at the luminal surface of the intestinal mucosa of guinea pig and rat
-
Rechkemmer G., Wahl M., Kuschinsky W., von Engelhardt W. pH-microclimate at the luminal surface of the intestinal mucosa of guinea pig and rat. Pflügers Arch. (1986) 407 33 40.
-
(1986)
Pflügers Arch.
, vol.407
, pp. 33-40
-
-
Rechkemmer, G.1
Wahl, M.2
Kuschinsky, W.3
Von Engelhardt, W.4
-
33
-
-
0346139338
-
Factors affecting the microclimate pH of the rat jejunum in ringer bicarbonate buffer
-
Legen I., Kristl A. Factors affecting the microclimate pH of the rat jejunum in ringer bicarbonate buffer. Biol. Pharm. Bull. (2003) 26 886 889.
-
(2003)
Biol. Pharm. Bull.
, vol.26
, pp. 886-889
-
-
Legen, I.1
Kristl, A.2
-
35
-
-
9644252691
-
Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: Analysis of affinity constants and comparison with PEPT1
-
Luckner P., Brandsch M. Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur. J. Pharm. Biopharm. (2005) 59 17 24.
-
(2005)
Eur. J. Pharm. Biopharm.
, vol.59
, pp. 17-24
-
-
Luckner, P.1
Brandsch, M.2
-
36
-
-
0037335192
-
An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: Characterization of transport routes
-
Tavelin S., Taipalensuu J., Hallbook F., Vellonen K.S., Moore V., Artursson P. An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes. Pharm. Res. (2003) 20 373 381.
-
(2003)
Pharm. Res.
, vol.20
, pp. 373-381
-
-
Tavelin, S.1
Taipalensuu, J.2
Hallbook, F.3
Vellonen, K.S.4
Moore, V.5
Artursson, P.6
-
37
-
-
19444375300
-
Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer
-
Lee K.J., Johnson N., Castelo J. et al. Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer. Eur. J. Pharm. Sci. (2005) 25 193 200.
-
(2005)
Eur. J. Pharm. Sci.
, vol.25
, pp. 193-200
-
-
Lee, K.J.1
Johnson, N.2
Castelo, J.3
-
40
-
-
0030946942
-
Molecular determinants of recognition for the intestinal peptide carrier
-
Swaan P.W., Tukker J.J. Molecular determinants of recognition for the intestinal peptide carrier. J. Pharm. Sci. (1997) 86 596 602.
-
(1997)
J. Pharm. Sci.
, vol.86
, pp. 596-602
-
-
Swaan, P.W.1
Tukker, J.J.2
-
41
-
-
21244441988
-
Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1
-
Biegel A., Gebauer S., Hartrodt B., Brandsch M., Neubert K., Thondorf I. Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J. Med. Chem. (2005) 48 4410 4419.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 4410-4419
-
-
Biegel, A.1
Gebauer, S.2
Hartrodt, B.3
Brandsch, M.4
Neubert, K.5
Thondorf, I.6
-
42
-
-
0346098120
-
The intestinal H+/peptide symporter PEPT1: Structure-affinity relationships
-
Brandsch M., Knutter I., Leibach F.H. The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur. J. Pharm. Sci. (2004) 21 53 60.
-
(2004)
Eur. J. Pharm. Sci.
, vol.21
, pp. 53-60
-
-
Brandsch, M.1
Knutter, I.2
Leibach, F.H.3
-
43
-
-
3042597717
-
Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin
-
Behrens I., Kamm W., Dantzig A.H., Kissel T. Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin. J. Pharm. Sci. (2004) 93 1743 1754.
-
(2004)
J. Pharm. Sci.
, vol.93
, pp. 1743-1754
-
-
Behrens, I.1
Kamm, W.2
Dantzig, A.H.3
Kissel, T.4
-
44
-
-
0029142558
-
Heterogeneity in the human intestinal cell line Caco-2 leads to differences in the transepithelial transport
-
Walter E., Kissel T. Heterogeneity in the human intestinal cell line Caco-2 leads to differences in the transepithelial transport. Eur. J. Pharm. Sci. (1995) 3 215 230.
-
(1995)
Eur. J. Pharm. Sci.
, vol.3
, pp. 215-230
-
-
Walter, E.1
Kissel, T.2
-
45
-
-
0029939330
-
In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system
-
Chong S., Dando S., Soucek K., Morrison R. In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system. Pharm. Res. (1996) 13 120 123.
-
(1996)
Pharm. Res.
, vol.13
, pp. 120-123
-
-
Chong, S.1
Dando, S.2
Soucek, K.3
Morrison, R.4
-
46
-
-
14644398632
-
Cell culture-based models for intestinal permeability: A critique
-
Balimane P.V., Chong S. Cell culture-based models for intestinal permeability: a critique. Drug Discov. Today (2005) 10 335 343.
-
(2005)
Drug Discov. Today
, vol.10
, pp. 335-343
-
-
Balimane, P.V.1
Chong, S.2
-
47
-
-
0016172670
-
Transport mechanisms of beta-lactam antibiotics across everted rat gut
-
Penzotti S.C. Jr., Poole J.W. Transport mechanisms of beta-lactam antibiotics across everted rat gut. J. Pharm. Sci. (1974) 63 1803 1806.
-
(1974)
J. Pharm. Sci.
, vol.63
, pp. 1803-1806
-
-
Penzotti Jr., S.C.1
Poole, J.W.2
-
48
-
-
0017755496
-
Absorption of amino penicillins from everted rat intestine
-
Dixon C., Mizen L.W. Absorption of amino penicillins from everted rat intestine. J. Physiol. (1977) 269 549 559.
-
(1977)
J. Physiol.
, vol.269
, pp. 549-559
-
-
Dixon, C.1
Mizen, L.W.2
-
49
-
-
0032930327
-
Structure-transport relationship for the intestinal small-peptide carrier: Is the carbonyl group of the peptide bond relevant for transport?
-
Schoenmakers R.G., Stehouwer M.C., Tukker J.J. Structure-transport relationship for the intestinal small-peptide carrier: is the carbonyl group of the peptide bond relevant for transport? Pharm. Res. (1999) 16 62 68.
-
(1999)
Pharm. Res.
, vol.16
, pp. 62-68
-
-
Schoenmakers, R.G.1
Stehouwer, M.C.2
Tukker, J.J.3
-
50
-
-
0141928631
-
Comparison of ceftibuten transport across Caco-2 cells and rat jejunum mounted on modified Ussing chambers
-
Menon R.M., Barr W.H. Comparison of ceftibuten transport across Caco-2 cells and rat jejunum mounted on modified Ussing chambers. Biopharm. Drug Dispos. (2003) 24 299 308.
-
(2003)
Biopharm. Drug Dispos.
, vol.24
, pp. 299-308
-
-
Menon, R.M.1
Barr, W.H.2
|