Stereological Analysis of the Mediodorsal Thalamic Nucleus in Schizophrenia: Volume, Neuron Number, and Cell Types

Journal of Comparative Neurology

Volumn 472, Issue 4, 2004, Pages 449-462

  Dorph Petersen, Karl Anton ^a   Pierri, Joseph N ^a   Sun, Zhuoxin ^b   Sampson, Allan R ^b   Lewis, David A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Cynomolgus monkeys; Depression; Fractionator; Haloperidol; Nucleator; Thalamus

Indexed keywords

BENZATROPINE; HALOPERIDOL; NEUROLEPTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; BRAIN SIZE; CELL COUNT; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN TISSUE; LONG TERM EXPOSURE; MONKEY; MOOD DISORDER; NERVE PROJECTION; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; STEREOMETRY; THALAMUS DORSOMEDIAL NUCLEUS;

ADULT; AGED; ALCOHOLISM; ALGORITHMS; ANIMALS; ANTIPSYCHOTIC AGENTS; AUTOPSY; CELL COUNT; COMORBIDITY; FEMALE; HUMANS; MACACA FASCICULARIS; MALE; MEDIODORSAL THALAMIC NUCLEUS; MIDDLE AGED; MOOD DISORDERS; NERVE NET; NEURONS; REFERENCE STANDARDS; SCHIZOPHRENIA;

EID: 1942484894     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.20055     Document Type: Article

References (64)

1. Andersen BB, Gundersen HJG. 1999. Pronounced loss of cell nuclei and anisotropic deformation of thick sections. J Microsc 196:69-73.
2. APA (American Psychiatric Association). 1994. DSM-IV. Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatry Association.
3. Baddeley AJ, Gundersen HJG, Cruz-Orive LM. 1986. Estimation of surface area from vertical sections. J Microsc 142:259-276.
4. Braak H, Weinel U. 1985. The percentage of projection neurons and local circuit neurons in different nuclei of the human thalamus. J Hirnforsch 26:525-530.
5. Byne W, Buchsbaum MS, Kemether E, Hazlett EA, Shinwari A, Mitropoulou V, Siever LJ. 2001. Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder. Arch Gen Psychiatry 58:133-140.
6. Byne W, Buchsbaum MS, Mattiace LA, Hazlett EA, Kemether E, Elhakem SL, Purohit DP, Haroutunian V, Jones L. 2002. Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia. Am J Psychiatry 159:59-65.
7. Clark AS, Schwartz ML, Goldman-Rakic PS. 1989. GABA-immunoreactive neurons in the mediodorsal nucleus of the monkey thalamus. J Chem Neuroanat 2:259-267.
8. Cullen TJ, Walker MA, Parkinson N, Craven R, Crow TJ, Esiri MM, Harrison PJ. 2003. A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia. Schizophr Res 60:157-166.
9. Danos P, Baumann B, Bernstein H-G, Franz M, Stauch R, Northoff G, Krell D, Falkai P, Bogerts B. 1998. Schizophrenia and anteroventral thalamic nucleus: selective decrease of parvalbumin-immunoreactive thalamocortical projection neurons. Psychiatry Res Neuroimag 82:1-10.
10. Danos P, Baumann B, Krämer AV, Bernstein H-G, Stauch R, Krell D, Falkai P, Bogerts B. 2003. Volumes of association thalamic nuclei in schizophrenia: a postmortem study. Schizophr Res 60:141-155.
11. Dewulf A. 1971. Anatomy of the normal human thalamus: topometry and standardized nomenclature. Amsterdam: Elsevier.
12. Dorph-Petersen K-A. 1999. Stereological estimation using vertical sections in a complex tissue. J Microsc 195:79-86.
13. Dorph-Petersen K-A, Nyengaard JR, Gundersen HJG. 2001. Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 204:232-246.
14. Elvevåg B, Goldberg TE. 2000. Cognitive impairment in schizophrenia is the core of the disorder. Crit Rev Neurobiol 14:1-21.
15. Fowler IL, Carr VJ, Carter NT, Lewin TJ. 1998. Patterns of current and lifetime substance use in schizophrenia. Schizophr Bull 24:443-455.
16. Gilbert AR, Rosenberg DR, Harenski K, Spencer S, Sweeney JA, Keshavan MS. 2001. Thalamic volumes in patients with first-episode schizophrenia. Am J Psychiatry 158:618-624.
17. Goldman-Rakic PS. 1994. Working memory dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci 6:348-357.
18. Gundersen HJG. 1977. Notes on the estimation of the numerical density of arbitrary profiles: the edge effect. J Microsc 111:219-223.
19. Gundersen HJG. 1986. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson. J Microsc 143:3-45.
20. Gundersen HJG. 1988. The nucleator. J Microsc 151:3-21.
21. Gundersen HJG, Jensen EB. 1987. The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229-263.
22. Gundersen HJG, Jensen EBV, Kiêu K, Nielsen J. 1999. The efficiency of systematic sampling in stereology-reconsidered. J Microsc 193:199-211.
23. Harding A, Halliday G, Caine D, Kril J. 2000. Degeneration of anterior thalamic nuclei differentiates alcoholics with amnesia. Brain 123:141-154.
24. Hashimoto T, Volk DW, Eggan SM, Mirnics K, Pierri JN, Sun Z, Sampson AR, Lewis DA. 2003. Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia. J Neurosci 23:6315-6326.
25. Heinsen H, Rüb U, Bauer M, Ulmar G, Bethke B, Schüler M, Böcker F, Eisenmenger W, Götz M, Korr H, Schmitz C. 1999. Nerve cell loss in the thalamic mediodorsal nucleus in Huntington's disease. Acta Neuropathol 97:613-622.
26. Hirai T, Jones EG. 1989. A new parcellation of the human thalamus on the basis of histochemical staining. Brain Res Rev 14:1-34.
27. Howard CV, Reed MG. 1998. Unbiased stereology. Three-dimensional measurement in microscopy. Oxford: Bios Scientific.
28. Hunt CA, Pang DZ, Jones EG. 1991. Distribution and density of GABA cells in intralaminar and adjacent nuclei of monkey thalamus. Neuroscience 43:185-196.
29. Jones EG. 1997. A description of the human thalamus. In: Steriade M, Jones EG, McCormick DA, editors. Thalamus, vol. II. Experimental and clinical aspects. Oxford: Elsevier Science. p 425-500.
30. Kuroda M, Price JL. 1991. Synaptic organization of projections from basal forebrain structures to the mediodorsal thalamic nucleus of the rat. J Comp Neurol 303:513-533.
31. Kuroda M, López-Mascaraque L, Price JL. 1992. Neuronal and synaptic composition of the mediodorsal thalamic nucleus in the rat: a light and electron microscopic Golgi study. J Comp Neurol 326:61-81.
32. Lange H, Thörner G, Hopf A, Schröder KF. 1976. Morphometric studies of the neuropathological changes in choreatic diseases. J Neurol Sci 28: 401-425.
33. Lesch A, Bogerts B. 1984. The diencephalon in schizophrenia: evidence for reduced thickness of the periventricular grey matter. Eur Arch Psychiatr Neurol Sci 234:212-219.
34. Letinic K, Rakic P. 2001. Telencephalic origin of human thalamic GABAergic neurons. Nat Neurosci 4:931-936.
35. Lewis DA. 2000. Is there a neuropathology of schizophrenia? Recent findings converge on altered thalamic-prefrontal cortical connectivity. Neuroscientist 6:208-218.
36. Lewis DA, Levitt P. 2002. Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci 25:409-432.
37. Lewis DA, Lieberman JA. 2000. Catching up on schizophrenia: natural history and neurobiology. Neuron 28:325-334.
38. Lewis DA, Cruz DA, Melchitzky DS, Pierri JN. 2001. Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamus. Am J Psychiatry 158:1411-1422.
39. Mattfeldt T, Mall G, Gharehbaghi H, Möller P. 1990. Estimation of surface area and length with the orientator. J Microsc 159:301-317.
40. McEvoy JP, Stiller RL, Farr R. 1986. Plasma haloperidol levels drawn at neuroleptic threshold doses: a pilot study. J Clin Psychopharmacol 6:133-138.
41. McEvoy JP, Hogarty GE, Steingard S. 1991. Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose. Arch Gen Psychiatry 48:739-745.
42. McLardy T. 1963. Thalamic microneurones. Nature 199:820-821.
43. Melchitzky DS, Sesack SR, Lewis DA. 1999. Parvalbumin-immunoreactive axon terminals in macaque monkey and human prefrontal cortex: laminar, regional and target specificity of Type I and Type II synapses. J Comp Neurol 408:11-22.
44. Mendis-Handagama SMLC, Ewing LL. 1990. Sources of error in the estimation of Leydig cell numbers in control and atrophied mammalian testes. J Microsc 159:73-82.
45. Mirnics K, Middleton FA, Marquez A, Lewis DA, Levitt P. 2000. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28:53-67.
46. Montero VM, Zempel J. 1986. The proportion and size of GABA-immunoreactive neurons in the magnocellular and parvocellular layers of the lateral geniculate nucleus of the rhesus monkey. Exp Brain Res 62:215-223.
47. Négyessy L, Takács J, Divac I, Hámori J. 1994. A combined Golgi and postembedding GABA and glutamate electron microscopic study of the nucleus dorsomedialis thalami of the rat. Neurobiology (Bp) 2:325-341.
48. Neter J, Kutner MH, Nachtsheim CJ, Wasserman W. 1996. Applied linear statistical models. Chicago: Irwin.
49. Nyengaard JR, Gundersen HJG. 1992. The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens. J Microsc 165:427-431.
50. Ottersen OP, Storm-Mathisen J. 1984a. GABA-containing neurons in the thalamus and pretectum of the rodent. An immunocytochemical study. Anat Embryol (Berl) 170:197-207.
51. Ottersen OP, Storm-Mathisen J. 1984b. Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immunocytochemical technique. J Comp Neurol 229:374-392.
52. Pakkenberg B. 1990. Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Arch Gen Psychiatry 47:1023-1028.
53. Pakkenberg B. 1992. The volume of the mediodorsal thalamic nucleus in treated and untreated schizophrenics. Schizophr Res 7:95-100.
54. Pakkenberg B, Gundersen HJG. 1988. Total number of neurons and glial cells in human brain nuclei estimated by the disector and the fractionator. J Microsc 150:1-20.
55. Popken GJ, Bunney WE Jr, Potkin SG, Jones EG. 2000. Subnucleus-specific loss of neurons in medial thalamus of schizophrenics. Proc Natl Acad Sci USA 97:9276-9280.
56. Shenton ME, Dickey CC, Frumin M, McCarley RW. 2001. A review of MRI findings in schizophrenia. Schizophr Res 49:1-52.
57. Siris SG, Bench C. 2003. Depression and schizophrenia. In: Hirsch SR, Weinberger DR, editors. Schizophrenia. Oxford: Blackwell. p 142-167.
58. Smith Y, Séguéla P, Parent A. 1987. Distribution of GABA-immunoreactive neurons in the thalamus of the squirrel monkey (Saimiri sciureus). Neuroscience 22:579-591.
59. Sullivan EV, Rosenbloom MJ, Serventi KL, Deshmukh A, Pfefferbaum A. 2003. Effects of alcohol dependence comorbidity and antipsychotic medication on volumes of the thalamus and pons in schizophrenia. Am J Psychiatry 160:1110-1116.
60. Tai Y, Yi H, Ilinsky IA, Kultas-Ilinsky K. 1995. Nucleus reticularis thalami connections with the mediodorsal thalamic nucleus: a light and electron microscopic study in the monkey. Brain Res Bull 38:475-488.
61. Weinberger DR, Berman KF, Zec RF. 1986. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry 43:114-124.
62. West MJ, Slomianka L, Gundersen HJG. 1991. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231:482-497.
63. Xuereb JH, Perry RH, Candy JM, Perry EK, Marshall E, Bonham JR. 1991. Nerve cell loss in the thalamus in Alzheimer's disease and Parkinson's disease. Brain 114:1363-1379.
64. Young KA, Manaye KF, Liang C-L, Hicks PB, German DC. 2000. Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia. Biol Psychiatry 47:944-953.