CCAAT/enhancer binding protein β regulates aromatase expression via multiple and novel cis-regulatory sequences in uterine leiomyoma

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 3, 2008, Pages 981-991

  Ishikawa, Hiroshi ^a   Fencki, Veysel ^a   Marsh, Erica E ^a   Yin, Ping ^a   Chen, Dong ^a   Cheng, You Hong ^a   Reisterd, Scott ^a   Lin, Zhihong ^a   Bulun, Serdar E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; CCAAT ENHANCER BINDING PROTEIN; CYCLIC AMP;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; UTERUS MYOMA;

EID: 40849100077     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-2507     Document Type: Article

References (40)

1. Attilakos G, Fox R 2005 Regression of tamoxifen-stimulated massive uterine fibroid after conversion to anastrozole. J Obstet Gynaecol 25:609-610
2. Rivera JA, Christopoulos S, Small D, Trifiro M 2004 Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature. J Clin Endocrinol Metab 89:3183-3188
3. Varelas FK, Papanicolaou AN, Vavatsi-Christaki N, Makedos GA, Vlassis GD 2007 The effect of anastrazole on symptomatic uterine leiomyomata. Obstet Gynecol 110:643-649
4. Shozu M, Murakami K, Segawa T, Kasai T, Inoue M 2003 Successful treatment of a symptomatic uterine leiomyoma in a perimenopausal woman with a nonsteroidal aromatase inhibitor. Fertil Steril 79:628-631
5. Farquhar CM, Steiner CA 2002 Hysterectomy rates in the United States 1990-1997. Obstet Gynecol 99:229-234
6. Stewart EA 2001 Uterine fibroids. Lancet 357:293-298
7. Bulun SE, Simpson ER, Word RA 1994 Expression of the CYP19 gene and its product aromatase cytochrome P450 in human uterine leiomyoma tissues and cells in culture. J Clin Endocrinol Metab 78:736-743
8. Sumitani H, Shozu M, Segawa T, Murakami K, Yang HJ, Shimada K, Inoue M2000 In situ estrogen synthesized by aromatase P450 in uterine leiomyoma cells promotes cell growth probably via an autocrine/intracrine mechanism. Endocrinology 141:3852-3861
9. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD, Mendelson CR, Bulun SE 1994 Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 15:342-355
10. Bulun SE, Lin Z, Imir G, Amin S, Demura M, Yilmaz B, Martin R, Utsunomiya H, Thung S, Gurates B, Tamura M, Langoi D, Deb S 2005 Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol Rev 57:359-383
11. Otubu JA, Buttram VC, Besch NF, Besch PK 1982 Unconjugated steroids in leiomyomas and tumor-bearing myometrium. Am J Obstet Gynecol 143:130-133
12. Zhao Y, Agarwal VR, Mendelson CR, Simpson ER 1996 Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 137:5739-5742
13. Zhao Y, Nichols JE, Bulun SE, Mendelson CR, Simpson ER 1995 Aromatase P450 gene expression in human adipose tissue. Role of a Jak/STAT pathway in regulation of the adipose-specific promoter. J Biol Chem 270:16449-16457
14. Shozu M, Sumitani H, Segawa T, Yang HJ, Murakami K, Kasai T, Inoue M 2002 Overexpression of aromatase P450 in leiomyoma tissue is driven primarily through promoter I.4 of the aromatase P450 gene (CYP19). J Clin Endocrinol Metab 87:2540-2548
15. Imir AG, Lin Z, Yin P, Deb S, Yilmaz B, Cetin M, Cetin A, Bulun SE 2007 Aromatase expression in uterine leiomyomata is regulated primarily by proximal promoters I.3/II. J Clin Endocrinol Metab 92:1979-1982
16. Zeitoun KM, Bulun SE 1999 Aromatase: a key molecule in the pathophysiology of endometriosis and a therapeutic target. Fertil Steril 72:961-969
17. Rossi MJ, Chegini N, Masterson BJ 1992 Presence of epidermal growth factor, platelet-derived growth factor, and their receptors in human myometrial tissue and smooth muscle cells: their action in smooth muscle cells in vitro. Endocrinology 130:1716-1727
18. Xue Q, Lin Z, Yin P, Milad MP, Cheng YH, Confino E, Reierstad S, Bulun SE 2007 Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5 CpG island in endometriosis. J Clin Endocrinol Metab 92:3261-3267
19. Ackerman GE, Smith ME, Mendelson CR, MacDonald PC, Simpson ER 1981 Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J Clin Endocrinol Metab 53:412-417
20. Zhou J, Gurates B, Yang S, Sebastian S, Bulun SE 2001 Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein β. Cancer Res 61:2328-2334
21. Deb S, Zhou J, Amin SA, Imir AG, Yilmaz MB, Lin Z, Bulun SE 2006 A novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters I.3 and II by disrupting a transcriptional complex in breast adipose fibroblasts. J Biol Chem 281[Erratum (2006) 281:9832]:2585-2597
22. Cheng YH, Richardson BD, Hubert MA, Handwerger S 2004 Isolation and characterization of the human syncytin gene promoter. Biol Reprod 70:694-701
23. Gurates B, Sebastian S, Yang S, Zhou J, Tamura M, Fang Z, Suzuki T, Sasano H, Bulun SE 2002 WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. J Clin Endocrinol Metab 87:4369-4377
24. Yang S, Fang Z, Suzuki T, Sasano H, Zhou J, Gurates B, Tamura M, Ferrer K, Bulun S 2002 Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased C/EBPβ in endometriosis is associated with overexpression of aromatase. J Clin Endocrinol Metab 87:2336-2345
25. Sofi M, Young MJ, Papamakarios T, Simpson ER, Clyne CD 2003 Role of CRE-binding protein (CREB) in aromatase expression in breast adipose. Breast Cancer Res Treat 79:399-407
26. Michael MD, Kilgore MW, Morohashi K, Simpson ER 1995 Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary. J Biol Chem 270:13561-13566
27. Clyne CD, Speed CJ, Zhou J, Simpson ER 2002 Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem 277:20591-20597
28. Lekstrom-Himes J, Xanthopoulos KG 1998 Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J Biol Chem 273:28545-28548
29. Poli V, Mancini FP, Cortese R 1990 IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63:643-653
30. Descombes P, Schibler U 1991 A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569-579
31. Mantena SR, Kannan A, Cheon YP, Li Q, Johnson PF, Bagchi IC, Bagchi MK 2006 C/EBPβ is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma. Proc Natl Acad Sci USA 103:1870-1875
32. Sterneck E, Tessarollo L, Johnson PF 1997 An essential role for C/EBPβ in female reproduction. Genes Dev 11:2153-2162
33. Marcinkowska E, Garay E, Gocek E, Chrobak A, Wang X, Studzinski GP 2006 Regulation of C/EBPβ isoforms by MAPK pathways in HL60 cells induced to differentiate by 1,25-dihydroxyvitamin D3. Exp Cell Res 312:2054-2065
34. Paquin A, Barnabe-Heider F, Kageyama R, Miller FD 2005 CCAAT/enhancer-binding protein phosphorylation biases cortical precursors to generate neurons rather than astrocytes in vivo. J Neurosci 25:10747-10758
35. Tang QQ, Gronborg M, Huang H, Kim JW, Otto TC, Pandey A, Lane MD 2005 Sequential phosphorylation of CCAAT enhancer-binding protein β by MAPKand glycogen synthase kinase 3β is required for adipogenesis. Proc Natl Acad Sci USA 102:9766-9771
36. Meng L, Zhou J, Sasano H, Suzuki T, Zeitoun KM, Bulun SE 2001 Tumor necrosis factor α and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor δ: mechanism of desmoplastic reaction. Cancer Res 61:2250-2255
37. Cai Z, Kwintkiewicz J, Young ME, Stocco C 2007 Prostaglandin E2 increases cyp19 expression in rat granulosa cells: implication of GATA-4. Mol Cell Endocrinol 263:181-189
38. Chen D, Reierstad S, Lin Z, Lu M, Brooks C, Li N, Innes J, Bulun SE 2007 Prostaglandin E2 induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH2-terminal kinase in adipose fibroblasts. Cancer Res 67:8914-8922
39. Lu M, Chen D, Lin Z, Reierstad S, Trauernicht AM, Boyer TG, Bulun SE 2006 BRCA1 negatively regulates the cancer-associated aromatase promoters I. 3 and II in breast adipose fibroblasts and malignant epithelial cells. J Clin Endocrinol Metab 91:4514-4519
40. Noble LS, Takayama K, Zeitoun KM, Putman JM, Johns DA, Hinshelwood MM, Agarwal VR, Zhao Y, Carr BR, Bulun SE 1997 Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab 82:600-606