Rapid communication: BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 11, 2006, Pages 4514-4519

  Lu, Meiling ^a   Chen, Dong ^a   Lin, Zhihong ^a   Reierstad, Scott ^a   Trauernicht, Amy M ^b   Boyer, Thomas G ^b   Bulun, Serdar E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; AROMATASE INHIBITOR; BRCA1 PROTEIN; BUCLADESINE; ESTRADIOL; ESTROGEN; FULVESTRANT; MESSENGER RNA; PHORBOL DIACETATE; PROSTAGLANDIN E2; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; DNA BINDING PROTEIN; PHORBOL ESTER; PHORBOL-12,13-DIACETATE; TRANSCRIPTION FACTOR;

ADIPOSE TISSUE; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER RISK; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; HORMONE SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; UPREGULATION; BREAST; BREAST TUMOR; CARCINOMA; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; ENZYMOLOGY; EPITHELIUM CELL; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE;

ADIPOSE TISSUE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; AROMATASE; BRCA1 PROTEIN; BREAST; BREAST NEOPLASMS; BUCLADESINE; CARCINOMA; CELL LINE, TUMOR; DINOPROSTONE; DNA-BINDING PROTEINS; EPITHELIAL CELLS; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PHORBOL ESTERS; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 33751534794     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2006-1364     Document Type: Article

References (30)

1. Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G, Enmark E, Pettersson K, Warner M, Gustafsson JA 2001 Mechanisms of estrogen action. Physiol Rev 81:1535-1565
2. Goss PE, Ingle JN, Martino S, Robert NJ, Muss HB, Piccart MJ, Castiglione M, Tu D, Shepherd LE, Pritchard KI, Livingston RB, Davidson NE, Norton L, Perez EA, Abrams JS, Therasse P, Palmer MJ, Pater JL 2003 A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer. N Engl J Med 349:1793-1802
3. Bulun SE, Lin Z, Imir G, Amin S, Demura M, Yilmaz B, Martin R, Utsunomiya H, Thung S, Gurates B, Tamura M, Langoi D, Deb S 2005 Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Pharmacol Rev 57:359-383
4. Simpson ER, Davis SR 2001 Minireview: aromatase and the regulation of estrogen biosynthesis-some new perspectives. Endocrinology 142:4589-4594
5. Sasano H, Harada N 1998 Intratumoral aromatase in human breast, endometrial, and ovarian malignancies. Endocr Rev 19:593-607
6. Miller WR, Dixon JM 2001 Local endocrine effects of aromatase inhibitors within the breast. J Steroid Biochem Mol Biol 79:93-102
7. Ackerman GE, Smith ME, Mendelson CR, MacDonald PC, Simpson ER 1981 Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture. J Clin Endocrinol Metab 53:412-417
8. O'Neill JS, Miller WR 1987 Aromatase activity in breast adipose tissue from women with benign and malignant breast diseases. Br J Cancer 56:601-604
9. Tekmal RR, Kirma N, Gill K, Fowler K 1999 Aromatase overexpression and breast hyperplasia, an in vivo model: continued overexpression of aromatase is sufficient to maintain hyperplasia without circulating estrogens, and aromatase inhibitors abrogate these preneoplastic changes in mammary glands. Endocr Relat Cancer 6:307-314
10. Yue W, Wang JP, Hamilton CJ, Demers LM, Santen RJ 1998 In situ aromatization enhances breast tumor estradiol levels and cellular proliferation. Cancer Res 58:927-932
11. Mahendroo MS, Mendelson CR, Simpson ER 1993 Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue. J Biol Chem 268:19463-19470
12. Agarwal VR, Bulun SE, Leitch M, Rohrich R, Simpson ER 1996 Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients. J Clin Endocrinol Metab 81:3843-3849
13. Evans CT, Corbin CJ, Saunders CT, Merrill JC, Simpson ER, Mendelson CR 1987 Regulation of estrogen biosynthesis in human adipose stromal cells. Effects of dibutyryl cyclic AMP, epidermal growth factor, and phorbol esters on the synthesis of aromatase cytochrome P-450. J Biol Chem 262:6914-6920
14. Zhao Y, Agarwal VR, Mendelson CR, Simpson ER 1996 Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene. Endocrinology 137:5739-5742
15. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, et al. 1994 A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266:66-71
16. Thompson ME, Jensen RA, Obermiller PS, Page DL, Holt JT 1995 Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet 9:444-450
17. Starita LM, Parvin JD 2003 The multiple nuclear functions of BRCA1: transcription, ubiquitination and DNA repair. Curr Opin Cell Biol 15:345-350
18. Houvras Y, Benezra M, Zhang H, Manfredi JJ, Weber BL, Licht JD 2000 BRCA1 physically and functionally interacts with ATF1. J Biol Chem 275:36230-36237
19. Zheng L, Annab LA, Afshari CA, Lee WH, Boyer TG 2001 BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. Proc Natl Acad Sci USA 98:9587-9592
20. Hu YF, Li R 2002 JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. Genes Dev 16:1509-1517
21. Zhang H, Somasundaram K, Peng Y, Tian H, Zhang H, Bi D, Weber BL, El-Deiry WS 1998 BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16:1713-1721
22. Phillips KW, Goldsworthy SM, Bennett LM, Brownlee HA, Wiseman RW, Davis BJ 1997 Brca1 is expressed independently of hormonal stimulation in the mouse ovary. Lab Invest 76:419-425
23. Hu Y, Ghosh S, Amleh A, Yue W, Lu Y, Katz A, Li R 2005 Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. Oncogene 24:8343-8348
24. Deb S, Zhou J, Amin SA, Imir AG, Yilmaz MB, Lin Z, Bulun SE 2006 A novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters I.3 and II by disrupting a transcriptional complex in breast adipose fibroblasts. J Biol Chem 281:2585-2597
25. Zhou J, Gurates B, Yang S, Sebastian S, Bulun SE 2001 Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta. Cancer Res 61:2328-2334
26. Ghosh S, Wu Y, Li R, Hu Y 2005 Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element. Oncogene 24:2236-2246
27. Ryde CM, Nicholls JE, Dowsett M 1992 Steroid and growth factor modulation of aromatase activity in MCF7 and T47D breast carcinoma cell lines. Cancer Res 52:1411-1415
28. Bulun SE, Price TM, Aitken J, Mahendroo MS, Simpson ER 1993 A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab 77:1622-1628
29. Brodie A, Long B, Lu Q 1998 Aromatase expression in the human breast. Breast Cancer Res Treat 49(Suppl 1):S85-S91; discussion, S109-S119
30. Chen S, Ye J, Kijima I, Kinoshita Y, Zhou D 2005 Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue. J Steroid Biochem Mol Biol 95:17-23