Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor α by dehydroepiandrosterone and other peroxisome proliferators

Molecular Pharmacology

Volumn 73, Issue 3, 2008, Pages 968-976

  Tamasi, Viola ^a   Michael Miller, Kristy K ^b   Ripp, Sharon L ^c   Vila, Ermin ^a   Geoghagen, Thomas E ^a   Prough, Russell A ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF EVANSVILLE   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; ALANINE DERIVATIVE; ASPARTIC ACID; LUCIFERASE; MESSENGER RNA; NAFENOPIN; OKADAIC ACID; OLIGONUCLEOTIDE; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PIRINIXIC ACID; PRASTERONE; SERINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; DNA RESPONSIVE ELEMENT; DRUG MECHANISM; ENZYME ACTIVITY; GENE ACTIVITY; GENE MUTATION; GENETIC TRANSFECTION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER CELL; MALE; MODULATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM; REPORTER GENE; STATISTICAL SIGNIFICANCE; WESTERN BLOTTING;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; DATA INTERPRETATION, STATISTICAL; DEHYDROEPIANDROSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; HEPATOCYTES; LUCIFERASES; MALE; MUTATION; NAFENOPIN; PEROXISOME PROLIFERATORS; PHOSPHORYLATION; PLASMIDS; PPAR ALPHA; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSFECTION;

EID: 40849086443     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.036780     Document Type: Article

References (41)

1. Adams M, Reginato MJ, Shao D, Lazar MA, and Chatterjee VK (1997) Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem 272:5128-5132.
2. Auboeuf D, Riusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, and Vidal H (1997) Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferators-activated receptors and liver X receptor alpha in humans; no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46:1319-1327.
3. Bayliss KM and Skett P (1996) Isolation and culture of human hepatocytes, in Human Cell Culture Protocols (Jones GE ed) pp 369-390, Humana Press, Inc., Totowa, NJ.
4. Berry MN, Edwards AM, Barritt GJ, Grivell MB, Halls HJ, Gannon BJ, and Friend DS (1991) Isolated hepatocytes, in Isolated Hepatocytes: Preparation, Properties, and Application (Burdon R, Van Knippenbur P, eds), pp 45-47, Elsevier Science B.V., Amsterdam.
5. Blanquart C, Barbier O, Fruchart JC, Staels B, and Glineur C (2003) Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J Steroid Biochem Mol Biol 85:267-273.
6. Boie Y, Adam M, Rushmore TH, and Kennedy BP (1993) Enantioselective activation of the peroxisome proliferator-activated receptor. J Biol Chem 268:5530-5534.
7. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
8. Camp HS and Tafuri SR (1997) Regulation of peroxisome proliferator-activated receptor γ activity by mitogen-activated protein kinase. J Biol Chem 272:10811-10816.
9. Chatfield K and Eastman A (2004) Inhibitors of protein phosphatases 1 and 2A differentially prevent intrinsic and extrinsic apoptosis pathways. Biochem Biophys Res Commun 323:1313-1320.
10. Escher P and Wahli W (2000) Peroxisome proliferators activated receptors: insight into multiple cellular functions. Mutat Res 448:121-138.
11. Falkner KC, Pinaire JA, Xiao GH, Geoghegan TE, Prough RA (2001) Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: involvement of both the glucocorticoid and pregnane X receptors. Mol Pharmacol 60:611-619.
12. Ferrini JB, Ourlin JC, Pichard L, Fabre G, and Maurel P (1998) Human hepatocyte culture, in Cytochrome P450 Protocols (Phillips IR and Shephard EA eds) pp 341-352, Humana Press, Totowa, NJ.
13. Gardner OS, Dewar BJ, Earp HS, Samet JM, Graves LM (2003) Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. J Biol Chem 278:46261-46269.
14. Gray JP, Burns KA, Leas TL, Perdew GH, Vanden Heuvel JP (2005) Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry 44:10313-10321.
15. Hu ED, Kim JB, Sarraf P, and Spiegelman BM (1996) Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARα. Science 274:2100-2103.
16. Hunter T (1995) Protein kinases and phosphatases: the Yin and yang of protein phosphorylation and signaling. Cell 80:225-236.
17. Isom HC and Georgoff I (1984) Quantitative assay for albumin-producing liver cells after simian virus 40 transformation of rat hepatocytes maintained in chemically defined medium. Proc Natl Acad Sci U S A 81:6378-6382.
18. Isseman I and Green S (1990) Activation of a new member of the steroid receptor superfamily by peroxisome proliferators. Nature 347:545-650.
19. Juge-Aubry CE, Hammar E, Siegrist-Kaiser C, Pernin A, Takeshita A, Chin WW, Burger AG, and Meier CA (1999) Regulation of the transcriptional activity of the peroxisome proliferator activated receptor α by phosphorylation of ligand-independent transactivating domain. J Biol Chem 274:10505-10510.
20. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
21. Latruffe N, Cherkaoui MM, Nicolas-Frances V, Clemencet M-C, Jannin B, and Berlot J-P (2000) Regulation of the peroxisomal β-oxidation dependent pathway by peroxisome proliferator-activated receptor and kinases. Biochem Pharmacol 60:1027-1032.
22. Lazarow PB (1981) Assay of peroxisomal beta-oxidation of fatty acids. Methods Enzymol 72:315-319.
23. Mukherjee R. Jow L. Croston GE, and Patemiti JR Jr (1997) Identification characterization, and tissue distribution of human peroxisome proliferators-activated receptor (PPAR) isoforms PPARγ2 versus PPAR 1 and activation with retinoid X receptor agonists and antagonists. J Biol Chem 272:8071-8076.
24. Palmer CNA, Hsu M-H, Griffin KJ, Raucy JL, and Johnson EF (1998) Peroxisome proliferators-activated receptor α expression in human liver. Mol Pharmacol 53:14-22.
25. Passilly P, Schohn H, Jannin B, Cherkaoui-Malki M, Boscoboinik D, Dauca M, Latruffe N (1999) Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol 58:1001-1008.
26. Peters JM, Zhou YC, Ram PA, Lee SS, Gonzalez FJ, and Waxman DJ (1996) Peroxisome proliferator-activated receptor α required for gene induction by dehydroepiandrosterone-3 β-sulfate. Mol Pharmacol 50:67-74.
27. Prough RA, Webb SJ, Wu HQ, Lapenson DP, and Waxman DJ (1994) Induction of microsomal and peroxisomal enzymes by dehydroepiandrosterone and its reduced metabolites in rats. Cancer Res 54:2878-2886.
28. Rao S, Subbarao V, Yeldandi SV, and Reddy JK (1992) Hepatocarcinogenicity of dehydroepiandrosterone in the rat. Cancer Res 52:2977-2979.
29. Reifel-Miller A, Calnek DS, and Grinnell BW (1994) Tyrosine phosphorylation regulates the DNA binding activity of a nuclear factor 1-like repressor protein. J Biol Chem 269:23861-23864.
30. Ripp SL, Falkner KC, Pendleton ML, Tamasi V, and Prough RA (2003) Regulation of CYP2C11 by dehydroepiandrosterone and peroxisome proliferators: identification of the negative regulatory region of the gene. Mol Pharmacol 64:113-122.
31. Shalev A, Siegrist-Kaiser CA, Yen PM, Wahli W, Burger AG, Chin WW, and Meier CA (1996) The peroxisome proliferators-activated receptor α is a phosphoprotein: regulation by insulin. Endocrinology 137:4499- 4502.
32. Shao DL, Rangwala SM, Bailey ST, Krakow SL, Reginato MJ, and Lazar MA (1998) Interdomain communication regulating ligand binding by PPAR-γ. Nature 396:377-380.
33. Sher T, Yi HF, McBride OW, and Gonzalez FJ (1993) cDNA cloning chromosomal mapping and functional characterization of the human peroxisome proliferators activated receptor. Biochemistry 32:5598-5604.
34. Shipley JM and Waxman DJ (2003) Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR)α and PPARγ. Mol Pharmacol 64:355-364.
35. +/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev 8:2527-2539.
36. Swales K and Negishi M (2004) CAR, driving into the future. Mol Endocrinol 18:1589-1598.
37. Tan SN, Michalik L, Desvergne B, and Wahli W (2005) Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. J Steroid Biochem Mol Biol 93:99-105.
38. Tirona RG and Kim RB (2005) Nuclear receptors and drug disposition gene regulation. J Pharm Sci 94:1169-1186.
39. Towbin H, Staehelin T, and Gordon J (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76:4350-4354.
40. LAù) by dehydroepiandrosterone in rats: A possible peroxisomal proliferators. Cancer Res 49:2337-2343.
41. Zhang B, Berger J, Zhou G, Elbrecht A, Biswas S, White-Carrington S, Szalkowski D, and Moller DE (1996) Insulin and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem 271:31771- 31774.